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Open Access
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Article |
Artificial confocal microscopy for deep label-free imaging
A laser scanning microscope equipped with quantitative phase imaging is trained with a neural network to perform artificial confocal microscopy
- Xi Chen
- , Mikhail E. Kandel
- & Gabriel Popescu
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Obituary |
In memory of Gabriel Popescu
Gabriel Popescu passed away in June 2022. He will be remembered as a creative leader in biophotonics, with pioneering contributions to quantitative phase imaging and spectroscopy, an engaging collaborator and a dear friend.
- Natan T. Shaked
- , YongKeun Park
- & Peter T. C. So
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Article |
Interferometric scattering microscopy reveals microsecond nanoscopic protein motion on a live cell membrane
Interferometric scattering microscopy is employed to track proteins in live cell membranes, demonstrating tracking of transmembrane epidermal growth factor receptors with nanometre precision in all three dimensions at up to microsecond speeds and for durations of tens of minutes.
- Richard W. Taylor
- , Reza Gholami Mahmoodabadi
- & Vahid Sandoghdar
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Article |
High-speed optical coherence tomography by circular interferometric ranging
Using an ultrafast, time-stretched frequency comb laser operating with repetition rates from 7.6 MHz to 18.9 MHz, a rapid and large-volumetric-field optical coherence tomography at an imaging rate of up to 7.5 volumes per second is demonstrated.
- Meena Siddiqui
- , Ahhyun S. Nam
- & Benjamin J. Vakoc
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Progress Article |
The emergence of optical elastography in biomedicine
The principles and applications of optical elastography for use in biological imaging are reviewed.
- Brendan F. Kennedy
- , Philip Wijesinghe
- & David D. Sampson
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Letter |
Optical control of excitation waves in cardiac tissue
Optogenetics makes it possible for dynamic patterns of visible light to control the behaviour of excitation waves in heart cells.
- Rebecca A. B. Burton
- , Aleksandra Klimas
- & Gil Bub
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News & Views |
Probing hyperbolic polaritons
Hyperbolic phonon polaritons confined to the subdiffraction limit exhibit encouragingly long lifetimes and group velocities as slow as 0.002c. Researchers use a time-resolved set-up sensitive to nanometre-scale optical fields to shed light on the exciting optical properties of hyperbolic materials.
- Joshua D. Caldwell
- , Igor Vurgaftman
- & Joseph G. Tischler
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News & Views |
White-light diffraction tomography
A clever extension to a classic phase-contrast microscope allows speckle-free three-dimensional quantitative phase imaging of living cells in a tomographic imaging mode.
- Arno Bouwens
- & Theo Lasser
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Article |
White-light diffraction tomography of unlabelled live cells
The three-dimensional structures of transparent objects, such as living cells, are captured by an imaging technique that uses white-light illumination and diffraction tomography to collect a stack of phase-based images.
- Taewoo Kim
- , Renjie Zhou
- & Gabriel Popescu
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News & Views |
Scattering in focus
Sustaining the ongoing revolution in optical microscopy will require gaining detailed insight into the optical fields in focal spots. Researchers have developed an elegant method for mapping the full electric vector field using just a metal nanosphere on a glass substrate.
- L. Kuipers
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Letter |
Nanointerferometric amplitude and phase reconstruction of tightly focused vector beams
An easily implementable reconstruction scheme is demonstrated for determining the full vectorial amplitude and relative phase distributions of highly confined electromagnetic fields with subwavelength resolution from a single-scan measurement. This scheme will help improve microscopy and nanoscopy techniques.
- Thomas Bauer
- , Sergej Orlov
- & Gerd Leuchs
Single-protein optical holography
Tracking tiny proteins sans fluorescence