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| Open AccessZebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment
- Raquel Brañas Casas
- , Alessandro Zuppardo
- & Natascia Tiso
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| Open AccessSprouty genes regulate activated fibroblasts in mammary epithelial development and breast cancer
- Jiyong Li
- , Rongze Ma
- & Pengfei Lu
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| Open AccessFOXP3 promote the progression of glioblastoma via inhibiting ferroptosis mediated by linc00857/miR-1290/GPX4 axis
- Wenpeng Cao
- , Ya He
- & Shan Lei
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| Open AccessMETTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway
- Lan Ma
- , Xi Zhou
- & Yongchu Pan
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| Open Accessp66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence
- Yaiza Potes
- , Juan C. Bermejo-Millo
- & Ignacio Vega-Naredo
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| Open AccessGermline specific genes increase DNA double-strand break repair and radioresistance in lung adenocarcinoma cells
- Wenqing Liu
- , Jan Willem Bruggeman
- & Geert Hamer
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| Open AccessLow androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans
- J. Zimmer
- , L. Mueller
- & M. Krivega
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| Open AccessGss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice
- Haixia Zhu
- , Yin Cheng
- & Bin Wu
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| Open AccessSingle-cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development
- Thaís A. R. Ramos
- , Sebastián Urquiza-Zurich
- & Vinicius Maracaja-Coutinho
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| Open AccessLysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death
- Cristina Duarte-Olivenza
- , Goretti Moran
- & Juan A. Montero
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| Open AccessMitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
- Ming-Qi Yan
- , Bing-Hong Zhu
- & Xiao-Man Liu
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| Open AccessCharacterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant
- Arun Prakash Mishra
- , Suzanne Hartford
- & Shyam K. Sharan
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| Open AccessThe long noncoding RNA nHOTAIRM1 is necessary for differentiation and activity of iPSC-derived spinal motor neurons
- Paolo Tollis
- , Erika Vitiello
- & Elisa Caffarelli
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| Open AccessKindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland
- Zhenbin Wang
- , Lei Zhang
- & Hongquan Zhang
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| Open AccessMRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium
- Anurag Kumar Singh
- , Amrita Rai
- & Guido Posern
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Article
| Open AccessKLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer
- Shufang Cai
- , Xiaoyu Wang
- & Delin Mo
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Article
| Open AccessE2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation
- Sha Song
- & Xianjue Ma
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| Open AccessPeptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination
- Hyun-Jung Kim
- , Hye-Rim Shin
- & Hyun-Mo Ryoo
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| Open AccessThe histone chaperone function of Daxx is dispensable for embryonic development
- Chang Sun
- , Yuan Qi
- & Amanda R. Wasylishen
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| Open AccessDeletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis
- Fenyong Yao
- , Shisheng Huang
- & Shuijin He
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| Open AccessPARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation
- Wei Chen
- , Qiukai E
- & Xuesen Zhang
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| Open AccessPRC1 suppresses a female gene regulatory network to ensure testicular differentiation
- So Maezawa
- , Masashi Yukawa
- & Satoshi H. Namekawa
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| Open AccessXrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes
- Xuebi Cai
- , Jessica M. Stringer
- & Karla J. Hutt
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| Open AccessThe EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion
- Yamato Fukui
- , Yasushi Hirota
- & Yutaka Osuga
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| Open AccessHNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells
- Jun Wei Chan
- , Claire Wen Ying Neo
- & Adrian Kee Keong Teo
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| Open AccessSCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice
- Guo Zheng
- , Yu Su
- & Yaxi Chen
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| Open AccessUSP18 is an essential regulator of muscle cell differentiation and maturation
- Cyriel Sebastiaan Olie
- , Adán Pinto-Fernández
- & Benedikt M. Kessler
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| Open AccessA novel Hoxd13 mutation causes synpolydactyly and promotes osteoclast differentiation by regulating pSmad5/p65/c-Fos/Rank axis
- Lishan Zhang
- , Ziqi Fang
- & Yanliang Lin
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| Open AccessSingle cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch
- Fa-Li Zhang
- , Yan-Qin Feng
- & Wei Shen
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| Open AccessWdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation
- Pei-Rung Wu
- , Shang-Yin Chiang
- & Ruey-Hwa Chen
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| Open AccessTranscriptional and post-transcriptional control of autophagy and adipogenesis by YBX1
- Ruifan Wu
- , Shengchun Feng
- & Qingyan Jiang
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Article
| Open AccessEmbryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome
- Yanyan Liu
- , Ziyuan Lin
- & Huaqin Sun
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| Open AccessEpigenetic priming of immune/inflammatory pathways activation and abnormal activity of cell cycle pathway in a perinatal model of white matter injury
- Anne-Laure Schang
- , Juliette Van Steenwinckel
- & Pierre Gressens
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| Open AccessGOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila
- Anna Frappaolo
- , Angela Karimpour-Ghahnavieh
- & Maria Grazia Giansanti
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| Open AccessRetinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome
- Elisa Maria Turco
- , Angela Maria Giada Giovenale
- & Jessica Rosati
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| Open AccessDeletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss
- Felicia A. Gilels
- , Jun Wang
- & Amy E. Kiernan
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| Open AccessTulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish
- Danna Jia
- , Pan Gao
- & Xiang Ren
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| Open AccessDiverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death
- Ruven Wilkens
- , Anne Hoffrichter
- & Philipp Koch
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| Open AccessThe accumulation of miR-125b-5p is indispensable for efficient erythroblast enucleation
- Fang Fang
- , Lei Xu
- & Xuetao Pei
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| Open AccessLineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells
- Chen Wang
- , Wen Tian
- & Yan Guo
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| Open AccessRNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival
- Rostislav Novak
- , Yamen Abu Ahmad
- & Amir Orian
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| Open AccessHnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis
- Yuyu Chen
- , Jinna Wu
- & Caixia Xu
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| Open AccessA dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis
- Ting Zhao
- , Yanhong Xiao
- & Xiao-Qiang Yu
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| Open AccessLoss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
- Maryam Aghadi
- , Ramy Elgendy
- & Essam M. Abdelalim
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| Open AccessCa2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling
- Ke-Yan Yang
- , Song Zhao
- & Tie-Shan Tang
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| Open AccessDevelopmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological features
- Divya Saro Varghese
- , Thilina T. Alawathugoda
- & Suraiya A. Ansari
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| Open AccessGermline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation
- Fu-Rong Bai
- , Qi-Qian Wu
- & Jing-Wen Wu
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| Open AccessCannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
- Aníbal Sánchez-de la Torre
- , Tania Aguado
- & Javier Palazuelos
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| Open Accessβ2-adrenergic receptor promotes liver regeneration partially through crosstalk with c-met
- Xiang Tao
- , Can Chen
- & Kai Huang
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