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| Open AccessTranscription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence
- Eros Di Giorgio
- , Liliana Ranzino
- & Claudio Brancolini
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Article
| Open AccessTRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma
- Donghee Kang
- , Hyun Jung Hwang
- & Jae-Seon Lee
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Article
| Open AccessInherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein
- Norio Motohashi
- , Katsura Minegishi
- & Yoshitsugu Aoki
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Article
| Open AccessHeterogeneity in leukemia cells that escape drug-induced senescence-like state
- David Miller
- , Kyra Kerkhofs
- & Samuel Benchimol
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Article
| Open AccessEpigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling
- Xinpei Sun
- , Qian Li
- & Yu Zhang
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Article
| Open AccessAccelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation
- Jinlong Suo
- , Rui Shao
- & Weiguo Zou
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Review Article
| Open AccessCrosstalk between G-quadruplex and ROS
- Songjiang Wu
- , Ling Jiang
- & Qinghai Zeng
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Article
| Open AccessRBM4 regulates cellular senescence via miR1244/SERPINE1 axis
- Luning Wang
- , Xiaohong Zhang
- & Wenjing Zhang
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Article
| Open AccessSplicing factor SRSF3 represses translation of p21cip1/waf1 mRNA
- Jeeho Kim
- , Ra Young Park
- & Takbum Ohn
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Article
| Open AccessSenescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation
- Baochi Ou
- , Yuan Liu
- & Jingjie Zhang
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Article
| Open AccessLoss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development
- Junguee Lee
- , Hae Joung Sul
- & Minho Shong
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Article
| Open AccessSTING mediates nuclear PD-L1 targeting-induced senescence in cancer cells
- Je-Jung Lee
- , So Young Kim
- & Jeon-Soo Shin
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Article
| Open AccessFBXW7 inactivation induces cellular senescence via accumulation of p53
- Longyuan Gong
- , Danrui Cui
- & Yongchao Zhao
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Article
| Open AccessNintedanib induces senolytic effect via STAT3 inhibition
- Hyun-Ji Cho
- , Jeong-A Hwang
- & Young-Sam Lee
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Article
| Open AccessSerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome
- Giorgia Catarinella
- , Chiara Nicoletti
- & Lucia Latella
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Article
| Open AccessThe kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer
- Chengbo Ji
- , Mili Zhang
- & Liang Yu
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Article
| Open AccessBlocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma
- Zhen-Yuan Zheng
- , Man-Yu Chu
- & Li-Yan Xu
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Article
| Open AccessmiR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing
- Wen-Zhen He
- , Mi Yang
- & Chang-Jun Li
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Article
| Open AccessKLF4 regulates TERT expression in alveolar epithelial cells in pulmonary fibrosis
- Hui Wang
- , Hongyang Xu
- & Jinghong Dai
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Article
| Open AccessLoss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype
- Seungyeon Ryu
- , Myeongwoo Jung
- & Eun Kyung Lee
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Review Article
| Open AccessAdipose tissue aging: mechanisms and therapeutic implications
- Min-Yi Ou
- , Hao Zhang
- & Qing-Feng Li
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Article
| Open AccessBlocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization
- Hao Liu
- , Dong Zhao
- & Ying Hu
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Article
| Open AccessGenome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence
- Paula Carpintero-Fernández
- , Michela Borghesan
- & Ana O’Loghlen
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Article
| Open AccessInduction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer
- Liping Chu
- , Yuxiu Qu
- & Wei Qi
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Article
| Open AccessEarly differential responses elicited by BRAFV600E in adult mouse models
- Giuseppe Bosso
- , Pablo Lanuza-Gracia
- & Maria A. Blasco
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Article
| Open AccessTransfer of the longevity-associated variant of BPIFB4 gene rejuvenates immune system and vasculature by a reduction of CD38+ macrophages and NAD+ decline
- Elena Ciaglia
- , Valentina Lopardo
- & Annibale Alessandro Puca
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Article
| Open AccessIrradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma
- Michele Zanoni
- , Alba Clara Sarti
- & Francesco Di Virgilio
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Article
| Open AccessEpimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16
- Haiyang Zhao
- , Tingting Zhao
- & Yun Qian
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Article
| Open AccessMCL1 nuclear translocation induces chemoresistance in colorectal carcinoma
- Dechen Fu
- , Luke Pfannenstiel
- & Brian Gastman
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Article
| Open AccessAutophagy facilitates age-related cell apoptosis—a new insight from senile cataract
- Jiani Huang
- , Wangshu Yu
- & Wei Han
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Article
| Open AccessCDK5RAP2 loss-of-function causes premature cell senescence via the GSK3β/β-catenin-WIP1 pathway
- Xidi Wang
- , Patrick Sipila
- & Ki-Young Lee
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Article
| Open AccessEarly senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma
- Ulrike Schoetz
- , Diana Klein
- & Kirsten Lauber
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Article
| Open AccessAge-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis
- Jingshen Zhuang
- , Xuebing Chen
- & Zhaoming Zhong
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Article
| Open AccessParadoxical implication of BAX/BAK in the persistence of tetraploid cells
- Jiayin Deng
- , Lucía G. Gutiérrez
- & Laura Senovilla
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Article
| Open Accessc-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA
- Bingyan Li
- , Guang Zhang
- & Yide Mei
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Article
| Open AccessFibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway
- Hongwei Lu
- , Chao Jia
- & Wei Wang
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Article
| Open AccessG-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence
- Shu-Ning Sun
- , Shi-Hao Ni
- & Lu Lu
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Article
| Open AccessPotential role of senescent macrophages in radiation-induced pulmonary fibrosis
- Lulu Su
- , Yinping Dong
- & Feiyue Fan
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Article
| Open AccessSequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1
- Huan-Tian Zhang
- , Tao Gui
- & Zhen-Gang Zha
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Article
| Open AccessHOXA5 counteracts the function of pathological scar-derived fibroblasts by partially activating p53 signaling
- Yimin Liang
- , Renpeng Zhou
- & Danru Wang
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Article
| Open AccessSTING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway
- Qiang Guo
- , Ximiao Chen
- & Xiaolei Zhang
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Article
| Open AccessTargeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides
- Magali Trayssac
- , Christopher J. Clarke
- & Lina M. Obeid
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Article
| Open AccessIonizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death
- Sandy Adjemian
- , Teodora Oltean
- & Peter Vandenabeele
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Article
| Open AccessQuercetin promotes in vitro maturation of oocytes from humans and aged mice
- Yongzhi Cao
- , Haibin Zhao
- & Yueran Zhao
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Article
| Open AccessOxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis
- Guiwen Ye
- , Zhongyu Xie
- & Huiyong Shen
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Article
| Open AccessZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts
- Ju-Hyeon Bae
- , Hyeon-Ju Jeong
- & Jong-Sun Kang
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Review Article
| Open AccessBCL-w: apoptotic and non-apoptotic role in health and disease
- Mariusz L. Hartman
- & Malgorzata Czyz
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Article
| Open AccessAQP1 modulates tendon stem/progenitor cells senescence during tendon aging
- Minhao Chen
- , Yingjuan Li
- & Yunfeng Rui
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Article
| Open AccessA functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence
- Nadine H. Brückmann
- , Sofie N. Bennedsen
- & Morten F. Gjerstorff