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Article
| Open AccessGRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability
- Doudou Liu
- , Chenzhong Xu
- & Jun Chen
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Article
| Open AccessSARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters
- Gemma Bogard
- , Johanna Barthelemy
- & Isabelle Wolowczuk
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Article
| Open AccessA potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss
- Barbara Peixoto Pinheiro
- , Marcus Müller
- & Hubert Löwenheim
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Article
| Open AccessKLF4 regulates TERT expression in alveolar epithelial cells in pulmonary fibrosis
- Hui Wang
- , Hongyang Xu
- & Jinghong Dai
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Article
| Open AccessEvolution of gene expression signature in mammary gland stem cells from neonatal to old mice
- Xiaoling Huang
- , Yue Xu
- & Zuoren Yu
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Article
| Open AccessMICU3 regulates mitochondrial Ca2+-dependent antioxidant response in skeletal muscle aging
- Yun-Fei Yang
- , Wu Yang
- & Qian Xiao
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Article
| Open AccessWestern diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR, and EMT pathways
- Ricardo Imbroisi Filho
- , Alan C. Ochioni
- & Patricia Zancan
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Review Article
| Open AccessRoles of tRNA metabolism in aging and lifespan
- Zheng Zhou
- , Bao Sun
- & Meng Bian
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Article
| Open AccessPLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging
- Anda Huna
- , Audrey Griveau
- & David Bernard
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Article
| Open AccessLoss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish
- Ting Zhao
- , Shengfan Ye
- & Jun Chen
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Article
| Open AccessAdult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6
- Yuelin Zhang
- , Liyan Guo
- & Qizhou Lian
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Article
| Open AccessQuercetin promotes in vitro maturation of oocytes from humans and aged mice
- Yongzhi Cao
- , Haibin Zhao
- & Yueran Zhao
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Article
| Open AccessAQP1 modulates tendon stem/progenitor cells senescence during tendon aging
- Minhao Chen
- , Yingjuan Li
- & Yunfeng Rui
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Article
| Open AccessP53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head
- Fei Zhang
- , Wuxun Peng
- & Zhihong Xie
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Article
| Open AccessLactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling
- Arnaud Tauffenberger
- , Hubert Fiumelli
- & Pierre J. Magistretti
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Article
| Open AccessSprouty1 is a weight-loss target gene in human adipose stem/progenitor cells that is mandatory for the initiation of adipogenesis
- Markus Mandl
- , Sonja A. Wagner
- & Werner Zwerschke
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Article
| Open AccessnNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis
- Costanza Montagna
- , Salvatore Rizza
- & Giuseppe Filomeni
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Article
| Open AccessNicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow
- Jie Song
- , Jing Li
- & Liang Peng
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Original Article
| Open AccessActivation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss
- Jiaqi Pang
- , Hao Xiong
- & Yiqing Zheng
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Original Article
| Open AccessAltered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses
- Isabel Cortegano
- , Mercedes Rodríguez
- & María Luisa Gaspar
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Original Article
| Open AccessClinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis
- Ning Cao
- , Tuling Liao
- & Xuetao Pei
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Original Article
| Open AccessDicer and microRNAs protect adult dopamine neurons
- Piotr Chmielarz
- , Julia Konovalova
- & Andrii Domanskyi
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Review
| Open AccessHepatocyte polyploidization and its association with pathophysiological processes
- Min-Jun Wang
- , Fei Chen
- & Yi-Ping Hu
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Original Article
| Open AccessHuman type H vessels are a sensitive biomarker of bone mass
- Liang Wang
- , Fei Zhou
- & Ying Xu
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Original Article
| Open AccessmiR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1
- Hong-fu Xie
- , Ying-zi Liu
- & Ji Li
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Original Article
| Open AccessInactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4
- Josefina Castex
- , Dominica Willmann
- & Thomas Günther
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Original Article
| Open AccessNotch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence
- Ye Tian
- , Ying Xu
- & Yufeng Dong
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Original Article
| Open AccessSumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation
- Bhavana Chhunchha
- , Eri Kubo
- & Dhirendra P Singh
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Original Article
| Open AccessImpaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice
- Swati Dawar
- , Nur Hezrin Shahrin
- & Sharad Kumar
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Original Article
| Open AccessMitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration
- Rita Valenzuela
- , Maria A Costa-Besada
- & Jose L Labandeira-Garcia
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Original Article
| Open AccessLoss of Rictor with aging in osteoblasts promotes age-related bone loss
- Pinling Lai
- , Qiancheng Song
- & Xiaochun Bai
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Original Article
| Open AccessRAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging
- P N Fernández Larrosa
- , M Ruíz Grecco
- & M A Costas
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Original Article
| Open AccessAge-related proteostasis and metabolic alterations in Caspase-2-deficient mice
- C H Wilson
- , S Shalini
- & S Kumar
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Original Article
| Open AccessDefective sarcoplasmic reticulum–mitochondria calcium exchange in aged mouse myocardium
- C Fernandez-Sanz
- , M Ruiz-Meana
- & D Garcia-Dorado
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Original Article
| Open AccessEarly and sustained altered expression of aging-related genes in young 3xTg-AD mice
- V Gatta
- , M D'Aurora
- & S L Sensi
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Original Article
| Open AccessDual role of the caspase enzymes in satellite cells from aged and young subjects
- S Fulle
- , S Sancilio
- & R Di Pietro
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Original Article
| Open AccessRole of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging
- P Burnley
- , M Rahman
- & D-M Su
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Original Article
| Open AccessRac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging
- A Bopp
- , F Wartlick
- & G Fritz
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Original Article
| Open AccessIncreased α-synuclein phosphorylation and nitration in the aging primate substantia nigra
- A L McCormack
- , S K Mak
- & D A Di Monte
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Original Article
| Open AccessLow glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells
- R Elanchezhian
- , P Palsamy
- & T Shinohara
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Original Article
| Open Accessc-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging
- C Giampietri
- , S Petrungaro
- & E Ziparo
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News and Commentary
| Open AccessLinking calorie restriction to longevity through sirtuins and autophagy: any role for TOR
- M V Blagosklonny