Featured
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| Open AccessCharacterization of BRCA2 R3052Q variant in mice supports its functional impact as a low-risk variant
- Arun Prakash Mishra
- , Suzanne Hartford
- & Shyam K. Sharan
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Article
| Open AccessThe EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion
- Yamato Fukui
- , Yasushi Hirota
- & Yutaka Osuga
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Article
| Open AccessHNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells
- Jun Wei Chan
- , Claire Wen Ying Neo
- & Adrian Kee Keong Teo
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Article
| Open AccessEmbryonic organizer formation disorder leads to multiorgan dysplasia in Down syndrome
- Yanyan Liu
- , Ziyuan Lin
- & Huaqin Sun
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Article
| Open AccessRetinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome
- Elisa Maria Turco
- , Angela Maria Giada Giovenale
- & Jessica Rosati
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Article
| Open AccessDeletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss
- Felicia A. Gilels
- , Jun Wang
- & Amy E. Kiernan
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Article
| Open AccessTulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish
- Danna Jia
- , Pan Gao
- & Xiang Ren
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Article
| Open AccessBloom syndrome helicase contributes to germ line development and longevity in zebrafish
- Tamás Annus
- , Dalma Müller
- & Máté Varga
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Article
| Open AccessModulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila
- Jung-Wan Mok
- & Kwang-Wook Choi
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Article
| Open AccessLoss of NEDD4 causes complete XY gonadal sex reversal in mice
- Simon P. Windley
- , Chloé Mayère
- & Dagmar Wilhelm
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Article
| Open AccessA missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis
- Yeming Yang
- , Xiao Li
- & Xianjun Zhu
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Article
| Open AccessImmune and nonimmune mechanisms mediate the mental stress-induced tumor growth in a xenograft model of breast cancer
- Wenjing Ma
- , Pengfei Liu
- & Zuoren Yu
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Article
| Open AccessThe transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling
- Nanchao Hong
- , Erge Zhang
- & Kun Sun
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Article
| Open AccessSodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells
- Binghua Liu
- , Weiyan Wang
- & Ke Liu
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Article
| Open AccessThe N-terminal BRCT domain determines MCPH1 function in brain development and fertility
- Xiaoqian Liu
- , Nadine Schneble-Löhnert
- & Zhao-Qi Wang
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Article
| Open AccessEfficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish
- Nicola Facchinello
- , Claudio Laquatra
- & Natascia Tiso
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Article
| Open AccessHuman iNSC-derived brain organoid model of lysosomal storage disorder in Niemann–Pick disease type C
- Seung-Eun Lee
- , Nari Shin
- & Kyung-Sun Kang
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Article
| Open AccessATRIP protects progenitor cells against DNA damage in vivo
- Gabriel E. Matos-Rodrigues
- , Paulius Grigaravicius
- & Rodrigo A. P. Martins
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Article
| Open AccessAssociation of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells
- Qian Chen
- , Sijia Jiang
- & Mei Zhong
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Article
| Open AccessUHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I
- Hongjie Pan
- , Ning Jiang
- & Runsheng Li
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Article
| Open AccessTransmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling
- Aimin Wu
- , Bing Yu
- & Daiwen Chen
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Article
| Open AccessThe orphan nuclear receptor Nr4a1 mediates perinatal neuroinflammation in a murine model of preterm labor
- Sarah M. Estrada
- , Andrew S. Thagard
- & Nicholas Ieronimakis
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Article
| Open AccessSevere head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs
- Emmanuelle Grall
- , Victor Gourain
- & Isabelle Duluc
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Article
| Open AccessCell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis
- Marc Oria
- , Soner Duru
- & Jose L. Peiro
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Article
| Open AccessCharacterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression
- Mingli Li
- , Shiyao Sun
- & Yun Fan
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Article
| Open AccessExogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants
- João M. A. Santos
- , Leonardo Mendes-Silva
- & José Bragança
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Article
| Open AccessBRCA2 deficiency is a potential driver for human primary ovarian insufficiency
- Yilong Miao
- , Pan Wang
- & Bo Xiong
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Article
| Open AccessThe alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood–testis barrier and results in hypospermatogenesis
- Ruilou Zhu
- , Jiangnan Wang
- & Chaojun Li
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Article
| Open AccessMKK3 modulates JNK-dependent cell migration and invasion
- Yihao Sun
- , Di zhang
- & Lei Xue
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Article
| Open AccessDrosophila Pif1A is essential for spermatogenesis and is the homolog of human CCDC157, a gene associated with idiopathic NOA
- Xin Yuan
- , Huimei Zheng
- & Xiaohang Yang
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Comment
| Open AccessCRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo
- Neeraj K Aryal
- , Amanda R Wasylishen
- & Guillermina Lozano
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Original Article
| Open AccessBax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases
- J Ngo
- , M Matsuyama
- & S Matsuyama
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Original Article
| Open AccessSlow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice
- H Z Yin
- , A Nalbandian
- & J H Weiss
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Original Article
| Open AccessEnhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98
- N M Alajez
- , W Shi
- & F-F Liu