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Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling
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TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits
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Alternative Wnt-signaling axis leads to a break of oncogene-induced senescence
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Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription
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Collagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression
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The LKB1–TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway
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Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins
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WWOX promotes osteosarcoma development via upregulation of Myc
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TRIM21-mediated Sohlh2 ubiquitination suppresses M2 macrophage polarization and progression of triple-negative breast cancer
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Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia
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The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling
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ETS-1-activated LINC01016 over-expression promotes tumor progression via suppression of RFFL-mediated DHX9 ubiquitination degradation in breast cancers
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NUCKS1, a LINC00629-upregulated gene, facilitated osteosarcoma progression and metastasis by elevating asparagine synthesis
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Review Article
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Effects of altered glycolysis levels on CD8+ T cell activation and function
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FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells
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The double-edged functions of necroptosis
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Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression
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TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α
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AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
- Ruihong Zhang
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Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate
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Endothelial cell-specific molecule 1 drives cervical cancer progression
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Bone morphogenetic protein 4 inhibits rat stem/progenitor Leydig cell development and regeneration via SMAD-dependent and SMAD-independent signaling
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The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells
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GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila
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Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA
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TAB182 aggravates progression of esophageal squamous cell carcinoma by enhancing β-catenin nuclear translocation through FHL2 dependent manner
- Aidi Gao
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Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders
- Haiyu Li
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DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism
- Zhenzhen Li
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PAF1 cooperates with YAP1 in metaplastic ducts to promote pancreatic cancer
- Rama Krishna Nimmakayala
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LncRNA SEMA3B-AS1 inhibits breast cancer progression by targeting miR-3940/KLLN axis
- Jin Hu
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SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction
- Huaping Zheng
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Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression
- Yi-Tung Chen
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Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest
- Johannes Wichmann
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Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3
- Bing Lu
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m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling
- Xin Liu
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Circular RNA circVAMP3 promotes aerobic glycolysis and proliferation by regulating LDHA in renal cell carcinoma
- Jun Li
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UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling
- Xuedi Gao
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Osteopontin promotes hepatocellular carcinoma progression through inducing JAK2/STAT3/NOX1-mediated ROS production
- Qipeng Wu
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CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma
- Min Tang
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LncRNA HOXC-AS3 promotes non-small-cell lung cancer growth and metastasis through upregulation of YBX1
- HongBo Su
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GITR/GITRL reverse signalling modulates the proliferation of hepatic progenitor cells by recruiting ANXA2 to phosphorylate ERK1/2 and Akt
- Yu He
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MESH1 knockdown triggers proliferation arrest through TAZ repression
- Tianai Sun
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Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction
- Qing Xiao
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Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A
- Zhuo Bao
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PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis
- Xiaowei Liu
- , Yuanxia Cai
- & Zhixiang Wu
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Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells
- Meng Zhang
- , Ruyi Peng
- & Jing Liu
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Myocardin/microRNA-30a/Beclin1 signaling controls the phenotypic modulation of vascular smooth muscle cells by regulating autophagy
- Danyang Shi
- , Jinhua Ding
- & Nan Wang
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Article
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Synthetic adiponectin-receptor agonist, AdipoRon, induces glycolytic dependence in pancreatic cancer cells
- Sharon J. Manley
- , Appolinaire A. Olou
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ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7