Developmental biology

Definition

Developmental biology is the field of biology that studies the processes by which multicellular organisms grow and develop, controlled by their genes. Knowledge of normal developmental processes can aid in the understanding of developmental abnormalities and other conditions such as cancer.

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Latest Research and Reviews

  • Research |

    Derivation of female mouse embryonic stem cells under certain conditions induces a loss of DNA methylation and erasure of genomic imprints, which are not recovered and that may contribute to observed impaired development.

    • Masaki Yagi
    • , Satoshi Kishigami
    • , Akito Tanaka
    • , Katsunori Semi
    • , Eiji Mizutani
    • , Sayaka Wakayama
    • , Teruhiko Wakayama
    • , Takuya Yamamoto
    •  & Yasuhiro Yamada
  • Research |

    Imaging in living Arabidopsis roots reveals that protein complexes can change their conformation in a cell-type-dependent manner to regulate specific gene expression programs leading to precise specification and maintenance of particular cell fates within the root meristem.

    • Yuchen Long
    • , Yvonne Stahl
    • , Stefanie Weidtkamp-Peters
    • , Marten Postma
    • , Wenkun Zhou
    • , Joachim Goedhart
    • , María-Isabel Sánchez-Pérez
    • , Theodorus W. J. Gadella
    • , Rüdiger Simon
    • , Ben Scheres
    •  & Ikram Blilou
  • Research |

    Inhibition of histone deacetylation allows the transcription factor Ascl1 to bind to key gene loci in Müller glia and drive the functional generation of retinal neurons in adult mice.

    • Nikolas L. Jorstad
    • , Matthew S. Wilken
    • , William N. Grimes
    • , Stefanie G. Wohl
    • , Leah S. VandenBosch
    • , Takeshi Yoshimatsu
    • , Rachel O. Wong
    • , Fred Rieke
    •  & Thomas A. Reh
  • Research |

    Ablation of hypothalamic stem/progenitor cells in mice leads to ageing-related decreases in physiological parameters and lifespan, and the speed of ageing is partially controlled by these cells through the release of exosomal miRNAs.

    • Yalin Zhang
    • , Min Soo Kim
    • , Baosen Jia
    • , Jingqi Yan
    • , Juan Pablo Zuniga-Hertz
    • , Cheng Han
    •  & Dongsheng Cai
  • Research |

    Long-term culture of male embryonic stem cells in naive conditions containing Mek1/2 and Gsk3a/b inhibitors leads to irreversible changes in epigenetic and genomic stability that compromise their in vivo developmental potential.

    • Jiho Choi
    • , Aaron J. Huebner
    • , Kendell Clement
    • , Ryan M. Walsh
    • , Andrej Savol
    • , Kaixuan Lin
    • , Hongcang Gu
    • , Bruno Di Stefano
    • , Justin Brumbaugh
    • , Sang-Yong Kim
    • , Jafar Sharif
    • , Christopher M. Rose
    • , Arman Mohammad
    • , Junko Odajima
    • , Jean Charron
    • , Toshi Shioda
    • , Andreas Gnirke
    • , Steven Gygi
    • , Haruhiko Koseki
    • , Ruslan I. Sadreyev
    • , Andrew Xiao
    • , Alexander Meissner
    •  & Konrad Hochedlinger
  • Research | | open

    Hematopoietic sites in the Drosophila larva require the local peripheral nervous system for blood cells (hemocytes) to survive and proliferate, but how this is mediated is unclear. Here, the authors identify Activin-β from sensory neurons as signalling to hemocytes, affecting proliferation and adhesion.

    • Kalpana Makhijani
    • , Brandy Alexander
    • , Deepti Rao
    • , Sophia Petraki
    • , Leire Herboso
    • , Katelyn Kukar
    • , Itrat Batool
    • , Stephanie Wachner
    • , Katrina S. Gold
    • , Corinna Wong
    • , Michael B. O’Connor
    •  & Katja Brückner

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