Cancer articles within Nature

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  • Article
    | Open Access

    Multi-modal analysis of genomically unstable ovarian tumours characterizes the contribution of anatomical sites and mutational processes to evolutionary phenotypic divergence and immune resistance mechanisms.

    • Ignacio Vázquez-García
    • , Florian Uhlitz
    •  & Sohrab P. Shah

  • Article |

    Results are presented that indicate that alterations to gene regulatory three-dimensional architecture are a critical mechanism that enables structural variant-based oncogene activation in cancer genomes and sheds light on the essential elements for such gene activation events.

    • Zhichao Xu
    • , Dong-Sung Lee
    •  & Jesse R. Dixon

  • Article
    | Open Access

    Rhythmic trafficking of dendritic cells to the tumour draining lymph node governs a circadian response of tumour-antigen-specific CD8+ T cells that is dependent on the circadian expression of the co-stimulatory molecule CD80.

    • Chen Wang
    • , Coline Barnoud
    •  & Christoph Scheiermann

  • Article
    | Open Access

    Aberrant crosstalk between cancer stem cells and their microenvironment triggers angiogenesis and TGFβ signalling, creating conditions that are conducive for hijacking leptin and leptin receptor signalling, which in turn launches downstream PI3K–AKT–mTOR signalling during the benign-to-malignant transition.

    • Shaopeng Yuan
    • , Katherine S. Stewart
    •  & Elaine Fuchs

  • Article |

    Integrated single-cell atlases of human fetal cerebella and MBs show potential cell populations predisposed to transformation and regulatory circuitries underlying tumour cell states and oncogenesis, highlighting hitherto unrecognized transitional progenitor intermediates predictive of disease prognosis.

    • Zaili Luo
    • , Mingyang Xia
    •  & Q. Richard Lu

  • News & Views |

    Structural insights into a long-studied folate-transport protein provide evidence that might lead to entirely new targeted anticancer treatments, or boost the success of immunotherapy approaches to tackling tumours.

    • Larry H. Matherly
    •  & Zhanjun Hou

  • Article |

    MYC dissociation from active promoters alters its interactions with proteins involved in transcription termination and RNA processing, influencing DNA repair and thus, potentially, tumour cell growth.

    • Daniel Solvie
    • , Apoorva Baluapuri
    •  & Martin Eilers

  • News & Views |

    Mounting evidence suggests that developing neurons and metastatic cancer cells migrate through similar mechanisms. Characterization of a previously unknown complex involved in cell migration confirms this idea.

    • Alain Chédotal

  • News & Views |

    Bacteria are frequently present in human cancers. The use of state-of-the-art methods for tumour analysis that capture spatial information and single-cell molecular profiles paves the way to clarifying the roles of these microorganisms.

    • Ilana Livyatan
    •  & Ravid Straussman

  • Article |

    Pathologically activated neutrophils, termed myeloid-derived suppressor cells, in the tumour microenvironment spontaneously undergo ferroptosis, which negatively regulates anti-tumour immunity through the release of oxygenated lipids, therefore limiting the activity of human and mouse T cells.

    • Rina Kim
    • , Ayumi Hashimoto
    •  & Dmitry I. Gabrilovich

  • News & Views |

    The generation of spatial maps that detail molecular and genetic information for the diverse cells and tissue environment of breast tumours offers insight into the factors that drive cancer progression.

    • Ghamdan Al-Eryani
    •  & Alexander Swarbrick

  • Research Briefing |

    The viscosity of extracellular fluid is a key physical cue, but its impact on cell function and cancer-cell dissemination has remained largely unknown. Experiments in various systems reveal that cancer cells sense, respond to and develop memory of the viscosity of extracellular fluid, with high viscosities increasing cell motility and promoting cancer dissemination.

  • Article
    | Open Access

    Melanoma cells interact with pain-mediating sensory neurons by increasing their release of the neuropeptide CGRP, which increases the exhaustion of CD8+ T cells and thus promotes the survival of cancer cells.

    • Mohammad Balood
    • , Maryam Ahmadi
    •  & Sebastien Talbot

  • Article
    | Open Access

    Single-cell whole-genome sequencing shows that 'foreground' cell-to-cell structural variation and alterations in copy number are associated with genomic diversity and evolution in triple-negative breast and high-grade serous ovarian cancers.

    • Tyler Funnell
    • , Ciara H. O’Flanagan
    •  & Samuel Aparicio

  • Article
    | Open Access

    A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

    • Timon Heide
    • , Jacob Househam
    •  & Andrea Sottoriva

  • Article
    | Open Access

    Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.

    • Jacob Househam
    • , Timon Heide
    •  & Trevor A. Graham

  • Clinical Briefing |

    Treatment with the drugs relatlimab and nivolumab before the surgical removal of a type of cancer called melanoma resulted in tumours becoming inviable in 57% of individuals, and no severe adverse effects were observed. People with a favourable treatment response had a better survival outcome than did those who did not respond.

  • Article |

    Extensive genomic analyses of the chromatin architecture in acute myeloid leukaemia reveals several characteristics, including subtype-specific distal enhancers and silencers, that may represent new anticancer therapeutic targets.

    • Jie Xu
    • , Fan Song
    •  & Feng Yue

  • Article
    | Open Access

    Patients with resectable clinical stage III or oligometastatic stage IV melanoma were given neoadjuvant relatlimab and nivolumab combination immunotherapy, which induced a high pathologic complete response rate, indicating the efficacy and safety of this regimen.

    • Rodabe N. Amaria
    • , Michael Postow
    •  & Hussein A. Tawbi

  • World View |

    Progress on one of the world’s biggest killers will stall without big registries linking scattered records.

    • T. S. Karin Eisinger-Mathason

  • Article
    | Open Access

    Cleaved and intact type I collagen have different effects on pancreatic ductal adenocarcinoma (PDAC), and remodelling of type I collagen—mediated through DDR1 signalling—is a prognostic indicator for the survival of patients with PDAC.

    • Hua Su
    • , Fei Yang
    •  & Michael Karin

  • Spotlight |

    Research oncologist Peter Mulatya has a job that takes him from conducting clinical trials to long discussions with patients and families.

    • Helen Santoro

  • Article |

    Subpopulations of cytokine-producing and myofibroblastic hepatic stellate cells, identified by single-cell RNA sequencing, protect against or promote the development of hepatocellular carcinoma via high expression of hepatocyte growth factor or type I collagen, respectively..

    • Aveline Filliol
    • , Yoshinobu Saito
    •  & Robert F. Schwabe

  • Article
    | Open Access

    A study examining DNA transfer from mitochondria to the nucleus using whole-genome sequences from 66,083 people shows that this is an ongoing dynamic process in normal cells with distinct roles in different types of cancer.

    • Wei Wei
    • , Katherine R. Schon
    •  & Patrick F. Chinnery

  • Article
    | Open Access

    Binding of the PD1-IL2v immunocytokine to PD-1 and IL-2Rβγ on the same cell leads to an alternative differentiation of stem-like CD8+ T cells into better effectors rather than exhausted T cells in models of both chronic infection and cancer.

    • Laura Codarri Deak
    • , Valeria Nicolini
    •  & Pablo Umaña

  • Article |

    The nuclear mitotic apparatus protein NuMA helps to protect genes from oxidative damage by occupying regions around transcription start sites, binding DNA repair factors and promoting transcription following damage.

    • Swagat Ray
    • , Arwa A. Abugable
    •  & Sherif F. El-Khamisy

  • Article |

    A hierarchical model of melanoma tumour growth mirrors the cellular and molecular logic of cell-fate specification and differentiation of the underlying embryonic neural crest, and suggests that the ability to support growth and metastasis are limited to distinct pools of cells.

    • Panagiotis Karras
    • , Ignacio Bordeu
    •  & Jean-Christophe Marine

  • Article |

    Multi-omic mapping shows that group 3 and group 4 medulloblastomas have a common, human-specific developmental origin in the cerebellar rhombic lip, providing a basis for their ambiguous molecular features and overlapping anatomical location, and for the difficulty of modelling these tumours in mice.

    • Kyle S. Smith
    • , Laure Bihannic
    •  & Paul A. Northcott

  • News & Views |

    How certain subgroups of a childhood brain tumour called a medulloblastoma arise has been unclear. Evidence now implicates a cell type found only in developing human brains as the originator of these tumours.

    • Timothy N. Phoenix

  • Article
    | Open Access

    Membrane-bound E3 ubiquitin ligases RNF43 and ZNRF3 are overexpressed in colorectal cancer, and can be repurposed using proteolysis-targeting antibodies (PROTABs) to selectively degrade cell-surface receptors in tumours.

    • Hadir Marei
    • , Wen-Ting K. Tsai
    •  & Felipe de Sousa e Melo

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