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Volume 2 Issue 1, January 2001

Neo-expressionistic depiction, inspired by A. Kiefer (b. 1945, Donaueschingen, Germany), of the massive deposition of complement (reddish-brown) at the maternal–fetal interface of an embryo, 9.5 days post coitum, in the absence of tryptophan catabolism. Mellor et al. (page 64) show that this deposition is antigen-driven, T cell-dependent and can occur in the complete absence of B cells. Original immunohistochemistry by Mellor et al.

Volume 2 Issue 1

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Editorial

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Correspondence

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Commentary

  • Are appropriate numbers of scientists being trained for research in immunology? Available data suggest that supply is not yet outstripping opportunities. The form of those opportunities, though, should change.

    • Howard H. Garrison
    • Paul W. Kincade
    Commentary
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News & Views

  • Remodeling of chromatin, distinct from activation of NF-κB, is a newly identified function of Toll-like receptors in mammals. In Drosophila , Toll receptors play a role in development as well as immunity; yet in mammals, they have an immunological role only. Further clues to the evolutionary development of the Toll receptors are emerging.

    • Bruce Beutler
    • Alexander Poltorak
    News & Views

  • Human hematopoietic stem cells are of vital scientific and clinical importance. Using high resolution clonal analysis, Dick and colleagues shed important new light on the developmental behavior of these cells in the context of an in vivo model system.

    • Ihor R. Lemischka
    • Craig T. Jordan
    News & Views

  • The newly rearranged T cell receptor on the surface of immature thymocytes must interact with not too much and not too little affinity for self-peptide–MHC ligands to allow the cell to mature and emigrate to the lymphoid periphery. Recent experiments shed new light on how the signal is perceived as “just right”.

    • Theodore J. Yun
    • Michael J. Bevan
    News & Views

  • The immunomodulatory character of bacterial CpG DNA is well known. A report in a recent issue of Nature pinpoints a Toll-like receptor as the cellular accomplice in this innate immune reaction.

    • Ruslan Medzhitov
    News & Views
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