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Decision making in the immune system

Immune cells integrate a variety of environmental cues and intrinsic programs to build a protective response. Nature Immunology presents a series of specially commissioned articles that discuss the molecular processes and extrinsic signals that influence fate decisions in the immune system.

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Editorial

Focus on decision making in the immune system

Elements of a good decision p645

doi:10.1038/ni0810-645

Signal integration, network complexities and genetic programming render the immune system ready to react to challenges from without and within.


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Reviews

Focus on decision making in the immune system

Programming dendritic cells to induce TH2 and tolerogenic responses pp647 - 655

Bali Pulendran, Hua Tang & Santhakumar Manicassamy

doi:10.1038/ni.1894


Focus on decision making in the immune system

Epithelial decision makers: in search of the 'epimmunome' pp656 - 665

Mahima Swamy, Colin Jamora, Wendy Havran & Adrian Hayday

doi:10.1038/ni.1905


Focus on decision making in the immune system

Decision checkpoints in the thymus pp666 - 673

Andrea C Carpenter & Rémy Bosselut

doi:10.1038/ni.1887


Focus on decision making in the immune system

Effector T cell plasticity: flexibility in the face of changing circumstances pp674 - 680

Kenneth M Murphy & Brigitta Stockinger

doi:10.1038/ni.1899


Focus on decision making in the immune system

Control systems and decision making for antibody production pp681 - 688

Christopher C Goodnow, Carola G Vinuesa, Katrina L Randall, Fabienne Mackay & Robert Brink

doi:10.1038/ni.1900


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Research Highlights

Focus on decision making in the immune system

Research Highlights p689

doi:10.1038/ni0810-689