NEWS AND VIEWS
Ageing: A toast to long life Toren Finkel
Nature 425, 132 (11 Sept 2003)
RESEARCH
Small
molecule activators of sirtuins extend Saccharomyces cerevisiae
lifespan
KT Howitz et al.
Nature 425,
191 (11 Sept 2003)
SIR2
Nicotinamide
and PNC1 govern lifespan extension by calorie restriction
in Saccharomyces cerevisiae.
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA.
Nature 423, 181 - 185 (08 May
2003)
Calorie
restriction extends Saccharomyces cerevisiae lifespan
by increasing respiration.
Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L.
Nature 418, 344 - 348 (18 Jul
2002)
Increased
dosage of a sir-2 gene extends lifespan in Caenorhabditis
elegans.
Tissenbaum HA, Guarente L.
Nature 410, 227 - 230 (08 Mar
2001)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Imai S, Armstrong CM, Kaeberlein M, Guarente L.
Nature 403, 795 - 800 (17 Feb
2003)
C.ELEGANS
Genes
that act downstream of DAF-16 to influence the lifespan of
Caenorhabditis elegans.
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C.
Nature 424, 277 - 283 (17 Jul
2003)
Stochastic
and genetic factors influence tissue-specific decline in ageing
C. elegans.
Herndon LA, Schmeissner PJ, Dudaronek JM, Brown PA, Listner KM, Sakano Y, Paupard MC, Hall DH, Driscoll M.
Nature 419, 808 - 814 (24 Oct
2002)
Regulation
of lifespan by sensory perception in Caenorhabditis elegans.
Apfeld J, Kenyon C.
Nature 402, 804 - 809 (16 Dec
1999) Letters to Nature
Signals
from the reproductive system regulate the lifespan of C.
elegans.
Hsin H, Kenyon C.
Nature 399, 362 - 366 (27 May
1999)
A
C. elegans mutant that lives twice as long as wild
type.
Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R.
Nature 366, 461 - 464 (02 Dec
1993)
The
Fork head transcription factor DAF-16 transduces insulin-like
metabolic and longevity signals in C. elegans.
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum
HA, Ruvkun G.
Nature 389, 994 - 999 (30 Oct
1997)
A
mutation in succinate dehydrogenase cytochrome b causes oxidative
stress and ageing in nematodes.
Ishii N, Fujii M, Hartman PS, Tsuda M, Yasuda K, Senoo-Matsuda
N, Yanase S, Ayusawa D, Suzuki K.
Nature 394, 694 - 697 (13 Aug
1998)
Chaperoning extended life.
Tatar M, Khazaeli AA, Curtsinger JW.
Nature 390, 30 (06 Nov 1997)
HUMAN
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.
Eriksson M. et al.
Nature 423, 293 - 298 (15 May
2003)
A
progeroid syndrome in mice is caused by defects in A-type
lamins.
Mounkes LC, Kozlov S, Hernandez L, Sullivan T, Stewart CL.
Nature 423, 298 - 301 (15 May
2003)
A telomerase component is defective in the human disease dyskeratosis congenita.
Mitchell JR, Wood E, Collins K.
Nature 402, 551 - 555 (02 Dec
1999)
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita.
Vulliamy T, Marrone A, Goldman F, Dearlove A, Bessler M, Mason PJ, Dokal I.
Nature 413, 432 - 435 (27 Sep
2001)
Telomere reduction in human colorectal carcinoma and with ageing.
Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC.
Nature 346, 866 - 868 (30 Aug
1990)
Telomeres shorten during ageing of human fibroblasts.
Harley CB, Futcher AB, Greider CW.
Nature 345, 458 - 460 (31 May
1990)
MOUSE
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y.
Nature 421, 182 - 187 (09 Jan
2003)
The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG.
Nature 402, 309 - 313 (18 Nov
1999)
p53 mutant mice that display early ageing-associated phenotypes.
Tyner S.D. et al
Nature 415, 45 - 53 (03 Jan 2002)
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
Kuro-o M. et al.
Nature 390, 45 - 51 (1997)
NATURE INSIGHT
Ageing
(9 November 2000)
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