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Scientific Correspondence
Nature 390, 30 (6 November 1997) | doi:10.1038/36237
Chaperoning extended life
Marc Tatar2, Aziz A. Khazaeli1 & James W. Curtsinger1
Abstract
The capacity to moderate internal and external stress is arguably the central function regulating senescence in whole-animal ageing1, 2, 3. During ageing, molecular chaperones such as heat-shock proteins are thought to combat stress-related senescent dysfunction4, 5. In transgenic Drosophila melanogaster, with varying copy numbers of the gene hsp70 encoding heat-shock protein hsp70, we found that heat-induced expression of hsp70 increased lifespan at normal temperatures. Only a brief, low level of expression was required to obtain a long-term improvement in survival.
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