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Micrornas

Lines of communication

Nature Reviews Cancer volume 12, pages 580–581 (2012)Cite this article

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microvesicles ... could induce HUVEC migration

The authors began by taking a non-biased approach to identify miRNAs that were differentially expressed in endothelial cells following co-culture with tissue-matched tumour cells. They found significant upregulation of a group of miRNAs in five endothelial cell lines, and this effect was replicated using conditioned media from the tumour cells, indicating that soluble factors might be responsible. The authors attempted to biochemically characterize the miRNA-inducing activity and isolated it to a large molecular weight fraction. They also found that endothelial cells did not exhibit changes in primary or precursor miRNAs following stimulation with conditioned media, but knockdown of the miRNA-processing enzyme DROSHA in tumour cells blocked miRNA induction, indicating that the miRNAs might be produced in the tumour cells and secreted in large molecular weight complexes, possibly microvesicles. They then isolated the microvesicles present in the conditioned media and showed they could be taken up by human umbilical vein endothelial cells (HUVECs) and could induce HUVEC migration, a process that was blocked by DROSHA knockdown in the tumour cells.

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ORIGINAL RESEARCH PAPERS

  1. Zhuang, G. et al. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 6 Jul 2012 (doi:10.1038/emboj.2012.183)

  2. Umezu, T. et al. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 16 Jul 2012 (doi:10.1038/onc.2012.295)

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  1. Sarah Seton-Rogers
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Seton-Rogers, S. Lines of communication. Nat Rev Cancer 12, 580–581 (2012). https://doi.org/10.1038/nrc3348

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