Developmental biology articles within Nature Reviews Cardiology

Featured

  • Review Article |

    Some species have a greater capacity for cardiac regeneration than others. In this Review, Weinberger and Riley summarize the diverse array of vertebrates that have been studied for their cardiac regenerative potential and the core mechanisms that regulate cardiac regeneration across vertebrate species.

    • Michael Weinberger
    •  & Paul R. Riley

  • Review Article |

    Advances in single-cell RNA sequencing technologies in the past 5 years have led to a greater understanding of endothelial cell development and heterogeneity. In this Review, Red-Horse and Trimm discuss the most up-to-date research on vascular endothelial cell development and diversity, and highlight the latest findings on organ-specific endothelial cells in the heart, brain, lungs, kidneys and liver.

    • Emily Trimm
    •  & Kristy Red-Horse

  • Review Article |

    Cilia are now known to have broad roles in cardiac development and disease. In this Review, Yuan and colleagues discuss the latest findings that link cilia function and biogenesis to congenital heart disease and describe the role of cilia in the development of cardiac left–right asymmetry, haemodynamic mechanosensation, valvulogenesis and myocardial regeneration.

    • Lydia Djenoune
    • , Kathryn Berg
    •  & Shiaulou Yuan

  • Research Highlight |

    A new study demonstrates a deficiency of NAD+ in patients with heart failure with preserved ejection fraction and indicates that restoration of NAD+ levels with nicotinamide supplementation might have therapeutic value to treat diastolic dysfunction in these patients.

    • Andrew Robson

  • Review Article |

    This Review summarizes the latest knowledge on cardiac lymphatic development, structure and function, discusses the role of the cardiac lymphatics after myocardial injury during fibrotic repair and regeneration, and highlights the therapeutic potential of targeting the cardiac lymphatics in myocardial infarction.

    • Konstantinos Klaourakis
    • , Joaquim M. Vieira
    •  & Paul R. Riley

  • News & Views |

    Mouse embryonic organoids that model cardiac development ex vivo could be used as a high-throughput, experimentally tractable system to evaluate crucial cell populations and environmental factors that contribute to normal and abnormal cardiogenesis.

    • Deepak Srivastava
    •  & Todd C. McDevitt

  • Review Article |

    In this Review, Tyrrell and Goldstein discuss vascular intrinsic and extrinsic mechanisms of how ageing promotes atherosclerosis, including changes in myeloid cells, mitochondrial dysfunction, impaired mitophagy and elevated IL-6 levels. They propose future steps for research and potential therapeutic approaches for age-related atherosclerosis.

    • Daniel J. Tyrrell
    •  & Daniel R. Goldstein

  • Review Article |

    In this Review, Murry and colleagues describe the hallmarks of cardiomyocyte maturation and the current approaches to mature stem cell-derived cardiomyocytes, highlighting challenges and future directions to generate cardiomyocytes with an optimal maturation state for use in research and regenerative medicine.

    • Elaheh Karbassi
    • , Aidan Fenix
    •  & Charles E. Murry

  • Review Article |

    Clonal haematopoiesis of indeterminate potential (CHIP) commonly occurs as a result of mutations in transcriptional regulators and is associated with a doubling of the risk of atherosclerotic cardiovascular disease. Jaiswal and Libby propose that CHIP contributes to the increased inflammation seen in ageing and thereby explains some of the age-related risk of cardiovascular disease.

    • Siddhartha Jaiswal
    •  & Peter Libby

  • Research Highlight |

    Two studies reporting novel insights into fibroblast identity and activation dynamics provide an important step forward in our understanding of cardiac fibrosis and the quest to develop new anti-fibrotic strategies

    • Irene Fernández-Ruiz

  • Review Article |

    In this Review, Mallat and colleagues critically evaluate the studies on the origin, fate and functions of vascular smooth muscle cells (VSMCs) in atherosclerosis, highlighting the importance of developmental origin, clonal expansion and plasticity of VSMCs cells in atherosclerosis and summarizing the roles of VSMCs and VSMC-derived cells in plaque development and progression.

    • Gemma L. Basatemur
    • , Helle F. Jørgensen
    •  & Ziad Mallat

  • Research Highlight |

    AIBP-mediated cholesterol efflux promotes the specification of haematopoietic stem and progenitor cells (HSPCs) in embryogenesis and induces adult HSPC expansion in hypercholesterolaemic conditions, mediated by SREBP2-regulated activation of Notch signalling.

    • Irene Fernández-Ruiz

  • Review Article |

    In this Review, Meilhac and Buckingham discuss the origin of cardiac cell populations, their lineage relationships and the genes that regulate their behaviour and differentiation. Characterizing the progenitor cells that form the heart and the gene regulatory networks controlling their deployment is of major importance for understanding the origin of congenital heart malformations and for developing cardiac regeneration therapies.

    • Sigolène M. Meilhac
    •  & Margaret E. Buckingham

  • Comment |

    Life expectancy around the world has increased steadily for nearly 200 years. This Focus Issue of Nature Reviews Cardiology features five insightful Review articles that describe numerous facets of the latest research on cardiovascular ageing.

    • Edward G. Lakatta

  • Review Article |

    Inflammageing is a chronic, pro-inflammatory state that develops with age and is a risk factor for cardiovascular disease, comorbidities, frailty, and death. In this Review, Ferrucci and Fabbri discuss whether therapies to modulate inflammageing can reduce the age-related decline in health.

    • Luigi Ferrucci
    •  & Elisa Fabbri

  • Review Article |

    Various intrinsic and extrinsic factors influence the balance between cellular renewal and senescence in the ageing heart. In this Review, Gude and colleagues discuss these factors, including environment, lifestyle, genetics and epigenetics, inflammation, and oxidative stress, and how they might be therapeutically targeted.

    • Natalie A. Gude
    • , Kathleen M. Broughton
    •  & Mark A. Sussman

  • Review Article |

    Alterations in mitochondrial function, which are amplified by defective mitochondrial quality control (MQC) mechanisms, are major contributing factors to cardiac senescence. In this Review, the authors discuss the mechanisms linking defective MQC to organelle dysfunction in the context of cardiac ageing and consider how these pathways might be targeted for the prevention and treatment of age-related heart dysfunction.

    • Anna Picca
    • , Robert T. Mankowski
    •  & Christiaan Leeuwenburgh

  • News & Views |

    Early studies showing that KIT+ cardiac progenitor cells (CPCs) could differentiate into cardiomyocytes generated excitement regarding their potential therapeutic application. Subsequent studies called their functional relevance into question, and while claims for a contribution of KIT+ CPCs to myocardial regeneration continue, two new studies confirm the doubts about their relevance to cardiomyogenesis and provide unexpected new insights.

    • Giovanni Maroli
    •  & Thomas Braun

  • Review Article |

    Cellular, molecular, and functional changes occur in the endothelium during ageing. Ungvari and colleagues explore the links between oxidative and nitrative stress and the conserved molecular pathways affecting endothelial dysfunction and impaired angiogenesis during ageing, and also speculate on how these pathological processes might be therapeutically targeted.

    • Zoltan Ungvari
    • , Stefano Tarantini
    •  & Anna Csiszar

  • News & Views |

    Revascularization of ischaemia-injured myocardium is critical for functional recovery. A new study shows that endothelial cells of neovessels in the injured heart derive from pre-existing endothelial cells. This new finding focuses research on therapeutic strategies to direct the neovasculature to deliver oxygen and nutrients effectively to the ischaemic myocardium.

    • Daniel M. Greif
    •  & Anne Eichmann

  • Review Article |

    In this Review, the authors present evidence for a causal relationship between the presence of large, dense, reactive platelets in the circulation and the onset of acute coronary syndromes (ACS). The increase in mean platelet volume in the pathogenesis of ACS can potentially overwhelm current therapeutics. Therefore, the control system for the production of these large platelets should be further researched to facilitate the development of new therapeutics that comprehensively prevent ACS.

    • John F. Martin
    • , Steen D. Kristensen
    •  & Fizzah A. Choudry

  • Review Article |

    Cardiac remodeling encompasses structural and functional changes of the left ventricle in response to stressors, and precedes clinical heart failure. Evaluation of cardiac remodeling can help to select patients with subclinical heart failure for early treatment. Drs Gjesdal, Blumke, and Lima review population-based studies of cardiac remodeling, describing risk factors, screening strategies, and outcome measures.

    • Ola Gjesdal
    • , David A. Bluemke
    •  & Joao A. Lima

  • Review Article |

    Induced pluripotent stem (iPS) cells are somatic cells that have been reprogrammed to an embryonic stem-cell-like state. This technology enables us to study the molecular mechanisms of development and disease processes, and provides a strategy for individualized diagnostics and therapy. In this Review, Timothy Nelson and colleagues describe the steps involved in bioengineering somatic cells to achieve pluripotency, allowing their differentiation into cardiomyocytes or any other cell type. Clinical applications of iPS cells, including treatment of cardiovascular conditions, are also discussed.

    • Timothy J. Nelson
    • , Almudena Martinez-Fernandez
    •  & Andre Terzic

Browse broader subjects

Browse narrower subjects

Browse Developmental biology across other nature.com journals