Featured
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Review Article |
Vascular endothelial cell development and diversity
Advances in single-cell RNA sequencing technologies in the past 5 years have led to a greater understanding of endothelial cell development and heterogeneity. In this Review, Red-Horse and Trimm discuss the most up-to-date research on vascular endothelial cell development and diversity, and highlight the latest findings on organ-specific endothelial cells in the heart, brain, lungs, kidneys and liver.
- Emily Trimm
- & Kristy Red-Horse
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Review Article |
Coronary vessel formation in development and disease: mechanisms and insights for therapy
The development of the coronary vasculature involves numerous cellular sources and a multitude of distinct processes. In this Review, Smart and colleagues describe the latest insights into the mechanisms involved in coronary vessel formation during development and disease, which might contribute to the identification of therapeutic targets for the promotion of neovascularization after myocardial infarction.
- Irina-Elena Lupu
- , Sarah De Val
- & Nicola Smart
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Research Highlight |
Distinct regulatory pathways are involved in coronary vessel growth
Three independent regulatory pathways contribute to neovascular growth during developmental coronary vessel growth and ischaemic injury.
- Karina Huynh
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Review Article |
Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes
The shear stress generated by flowing blood has major effects on vascular function, with low shear stress promoting vascular dysfunction and atherosclerosis. This Review describes the latest findings on how endothelial cells decode complex shear stress environments to regulate physiological and pathophysiological responses, highlighting the role of pathways involved in embryonic development.
- Celine Souilhol
- , Jovana Serbanovic-Canic
- & Paul C. Evans
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Review Article |
Endothelial dysfunction and angiogenesis impairment in the ageing vasculature
Cellular, molecular, and functional changes occur in the endothelium during ageing. Ungvari and colleagues explore the links between oxidative and nitrative stress and the conserved molecular pathways affecting endothelial dysfunction and impaired angiogenesis during ageing, and also speculate on how these pathological processes might be therapeutically targeted.
- Zoltan Ungvari
- , Stefano Tarantini
- & Anna Csiszar
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Review Article |
Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials
This Review summarizes the growing body of evidence implicating cathepsin activities in the pathogenesis of several cardiovascular diseases, outlining the potential of cathepsins as biomarkers of disease progression and discussing clinical trials of cathepsin inhibitors in other diseases that highlight opportunities for developing novel therapies targeting cathepsins in cardiovascular diseases.
- Cong-Lin Liu
- , Junli Guo
- & Guo-Ping Shi
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News & Views |
Where do new endothelial cells come from in the injured heart?
Revascularization of ischaemia-injured myocardium is critical for functional recovery. A new study shows that endothelial cells of neovessels in the injured heart derive from pre-existing endothelial cells. This new finding focuses research on therapeutic strategies to direct the neovasculature to deliver oxygen and nutrients effectively to the ischaemic myocardium.
- Daniel M. Greif
- & Anne Eichmann
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Review Article |
Therapeutic angiogenesis for critical limb ischaemia
Critical limb ischaemia (CLI) is the most-severe clinical manifestation of peripheral arterial disease (PAD), and is associated with a high risk of amputation and death. Therapeutic angiogenesis is an approach to stimulating blood vessel growth to improve tissue perfusion, and has the potential to benefit patients with CLI for whom revascularization is not an option. Here, Brian Annex reviews data from clinical trials of therapeutic angiogenesis in patients with PAD, and discusses how advances in systems biology, genetics, and gene therapy might be used in new approaches to this therapy.
- Brian H. Annex