Senescence articles within Nature Reviews Cardiology

Featured

  • Review Article |

    In this Review, Mallat and colleagues critically evaluate the studies on the origin, fate and functions of vascular smooth muscle cells (VSMCs) in atherosclerosis, highlighting the importance of developmental origin, clonal expansion and plasticity of VSMCs cells in atherosclerosis and summarizing the roles of VSMCs and VSMC-derived cells in plaque development and progression.

    • Gemma L. Basatemur
    • , Helle F. Jørgensen
    •  & Ziad Mallat

  • Review Article |

    Various intrinsic and extrinsic factors influence the balance between cellular renewal and senescence in the ageing heart. In this Review, Gude and colleagues discuss these factors, including environment, lifestyle, genetics and epigenetics, inflammation, and oxidative stress, and how they might be therapeutically targeted.

    • Natalie A. Gude
    • , Kathleen M. Broughton
    •  & Mark A. Sussman

  • Review Article |

    Alterations in mitochondrial function, which are amplified by defective mitochondrial quality control (MQC) mechanisms, are major contributing factors to cardiac senescence. In this Review, the authors discuss the mechanisms linking defective MQC to organelle dysfunction in the context of cardiac ageing and consider how these pathways might be targeted for the prevention and treatment of age-related heart dysfunction.

    • Anna Picca
    • , Robert T. Mankowski
    •  & Christiaan Leeuwenburgh

  • Review Article |

    Telomere shortening, along with various other endogenous and environmental factors, can drive cells into senescence, which is involved in the complex process of biological ageing. In this Review, Fyhrquist and colleagues discuss the associations between cardiovascular risk factors and telomere shortening, and whether cellular senescence has a causal role in conditions such as atherosclerosis, heart failure, and hypertension.

    • Frej Fyhrquist
    • , Outi Saijonmaa
    •  & Timo Strandberg

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