Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

GENE THERAPY

Gene therapy against Hippo triggers cardiomyocyte renewal after MI

Nature Reviews Cardiology volume 18, page 611 (2021)Cite this article

Subjects

Gene therapy to knock down the endogenous Hippo pathway in cardiomyocytes induces tissue renewal and improves heart function in adult pigs after myocardial infarction (MI), according to a new study. “Our study is an important step towards translation of gene therapy to treat ischaemic cardiomyopathy in humans,” comment study investigators Shijie Liu and James Martin.

Therefore, the research team used a pig model of ischaemic heart disease to investigate whether adeno-associated virus 9 (AAV9)-based gene therapy to knock down the Hippo pathway gene Sav promotes endogenous cardiomyocyte renewal after MI. An AAV9 vector encoding a short hairpin RNA (shRNA) against Sav or a control AAV9 vector was administered 2 weeks after induction of MI in pigs, delivered directly to cardiomyocytes in the infarct border zone via a catheter-based NOGA electromechanical mapping system.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

  • Liu, S. et al. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci. Transl Med. 13, eabd6892 (2021)

    Article  CAS  Google Scholar 

Related article

  • Wang, J. et al. The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nat. Rev. Cardiol. 15, 672–684 (2018)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Irene Fernández-Ruiz

Authors
  1. Irene Fernández-Ruiz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Irene Fernández-Ruiz.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fernández-Ruiz, I. Gene therapy against Hippo triggers cardiomyocyte renewal after MI. Nat Rev Cardiol 18, 611 (2021). https://doi.org/10.1038/s41569-021-00602-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41569-021-00602-8

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research