Review Article |
Featured
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Review Article |
Vascular endothelial cell development and diversity
Advances in single-cell RNA sequencing technologies in the past 5 years have led to a greater understanding of endothelial cell development and heterogeneity. In this Review, Red-Horse and Trimm discuss the most up-to-date research on vascular endothelial cell development and diversity, and highlight the latest findings on organ-specific endothelial cells in the heart, brain, lungs, kidneys and liver.
- Emily Trimm
- & Kristy Red-Horse
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Review Article |
A change of heart: new roles for cilia in cardiac development and disease
Cilia are now known to have broad roles in cardiac development and disease. In this Review, Yuan and colleagues discuss the latest findings that link cilia function and biogenesis to congenital heart disease and describe the role of cilia in the development of cardiac left–right asymmetry, haemodynamic mechanosensation, valvulogenesis and myocardial regeneration.
- Lydia Djenoune
- , Kathryn Berg
- & Shiaulou Yuan
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News & Views |
Mouse gastruloids take heart
Mouse embryonic organoids that model cardiac development ex vivo could be used as a high-throughput, experimentally tractable system to evaluate crucial cell populations and environmental factors that contribute to normal and abnormal cardiogenesis.
- Deepak Srivastava
- & Todd C. McDevitt
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Review Article |
Cardiac remodeling at the population level—risk factors, screening, and outcomes
Cardiac remodeling encompasses structural and functional changes of the left ventricle in response to stressors, and precedes clinical heart failure. Evaluation of cardiac remodeling can help to select patients with subclinical heart failure for early treatment. Drs Gjesdal, Blumke, and Lima review population-based studies of cardiac remodeling, describing risk factors, screening strategies, and outcome measures.
- Ola Gjesdal
- , David A. Bluemke
- & Joao A. Lima
Animal models to study cardiac regeneration