Differentiation articles within Nature Reviews Cardiology

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  • Review Article |

    In this Review, Mallat and colleagues critically evaluate the studies on the origin, fate and functions of vascular smooth muscle cells (VSMCs) in atherosclerosis, highlighting the importance of developmental origin, clonal expansion and plasticity of VSMCs cells in atherosclerosis and summarizing the roles of VSMCs and VSMC-derived cells in plaque development and progression.

    • Gemma L. Basatemur
    • , Helle F. Jørgensen
    •  & Ziad Mallat

  • Review Article |

    Induced pluripotent stem (iPS) cells are somatic cells that have been reprogrammed to an embryonic stem-cell-like state. This technology enables us to study the molecular mechanisms of development and disease processes, and provides a strategy for individualized diagnostics and therapy. In this Review, Timothy Nelson and colleagues describe the steps involved in bioengineering somatic cells to achieve pluripotency, allowing their differentiation into cardiomyocytes or any other cell type. Clinical applications of iPS cells, including treatment of cardiovascular conditions, are also discussed.

    • Timothy J. Nelson
    • , Almudena Martinez-Fernandez
    •  & Andre Terzic

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