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Volume 18 Issue 1, January 2022

COVER: Inspired by the Review on p9.

Cover design: S.Harris

Volume 18 Issue 1


  • Built by and for the research community, the Musculoskeletal Knowledge Portal (MSK-KP) offers researchers a single integrated platform on which to display, access, distill and explore results from large genomic and epigenomic studies to formulate hypotheses and accelerate the development of patient-centered therapeutics for complex, multi-factorial conditions such as osteoarthritis.

    • Jennifer J. Westendorf
    • Lynda F. Bonewald
    • Noël P. Burtt


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Research Highlights

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News & Views

  • Smoking during adulthood is a known risk factor for seropositive rheumatoid arthritis (RA) but how exposure to passive smoking affects RA risk is uncertain. New data from the Nurses’ Health Study on passive smoking over a lifetime suggest childhood exposure could be an important factor for future RA development.

    • Lars Klareskog
    News & Views
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  • Differentiating between the early stages of systemic lupus erythematosus (SLE) and undifferentiated connective tissue disease (UCTD) can be challenging. In this Review, the authors summarize current knowledge on UCTD and early-stage SLE and discuss clinical approaches to diagnosing these conditions.

    • Savino Sciascia
    • Dario Roccatello
    • Marta Mosca
    Review Article
  • Vasculitis, inflammation of the blood vessels, takes many forms and can affect every organ system, potentially causing kidney failure, vision loss and death. This Review describes current knowledge on the global incidence and prevalence patterns for various types of vasculitis.

    • Richard A. Watts
    • Gulen Hatemi
    • Aladdin J. Mohammad
    Review Article
  • Knee joint distraction (KJD) is used to stimulate joint repair in advanced osteoarthritis. In the Review, Jansen and Mastbergen provide an overview of the clinical trial results of KJD treatment, current knowledge of the molecular mechanisms underlying joint repair in KJD, and future directions and unanswered questions in KJD research and treatment.

    • Mylène P. Jansen
    • Simon C. Mastbergen
    Review Article
  • In this Review, the authors discuss the immunometabolic alterations involved in the pathogenesis of intervertebral disc degeneration, including the role of adipokines in impaired metabolism in intervertebral disc cells, and discuss opportunities for future research and development of new therapies.

    • Vera Francisco
    • Jesús Pino
    • Oreste Gualillo
    Review Article
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