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In a rigorous randomized controlled trial, treatment with platelet-rich plasma did not improve knee osteoarthritis symptoms or slow disease progression.
The results of a phase IIb study suggest that ianalumab, an anti-BAFF receptor antibody, could have disease-modifying effects in primary Sjögren syndrome.
Results of a case–control study suggest that delayed hypersensitivity reactions to IL-1 or IL-6 inhibitors are strongly associated with a common HLA class II haplotype.
In a multicentre, longitudinal study, researchers have evaluated the association of baseline criteria in patients with Raynaud phenomenon and 5-year progression to systemic sclerosis.
Results from the iFAME-Fertility study indicate that pre-conception paternal inflammatory arthritis is associated with the subsequent risk of miscarriage.
New research reports that men with inflammatory arthritis experience an impact on sexual health beyond erectile dysfunction, affecting their emotional, mental, and social health. Training to empower health professionals to have conversations about sex could improve support for people with rheumatic diseases.
The pathways involved in sensing and responding to mechanical stimuli have important roles in maintaining cartilage health, and can contribute to disease when dysregulated. This Review discusses cartilage mechanosignalling pathways and how they can be targeted to treat osteoarthritis.
In this Review, the authors summarize the clinical features, management and prognosis of acute exacerbation of interstitial lung disease in patients with rheumatic diseases, and discuss the definitions and diagnostic criteria for this often life-threatening condition.
In this Review, Choi et al. review the pathogenesis of cardiometabolic-renal comorbidities of gout and discuss potential therapies to concurrently reduce serum urate concentrations and risk of gout cardiometabolic-renal comorbidities.
In this Review, the authors introduce the application of artificial intelligence, in particular machine learning and deep learning, for improving multiple stages of MRI, including acquisition, processing and post-processing steps, for studying osteoarthritis.
