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Volume 20 Issue 3, March 2024

Inspired by the Review on p143.

Cover design: Steven Hall

Comment

  • As in rheumatoid arthritis, achieving low disease activity or remission in psoriatic arthritis (PsA) remains a challenge and unmet need for many individuals. However, the complex pathogenesis, heterogeneity and varied tissue involvement in PsA mean that dedicated definitions and novel solutions are required for difficult-to-treat disease.

    • Stefan Siebert
    • Helena Marzo-Ortega
    Comment

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Research Highlights

  • A meta-analysis of data from six genome-wide association study cohorts implicates several signalling pathways, including Hedgehog and Notch signalling, in Dupuytren disease.

    • Sarah Onuora
    Research Highlight
  • The voltage-gated sodium channel Nav1.7 is expressed on chondrocytes, regulates chondrocyte biology and osteoarthritis progression, and is a promising dual target for modifying disease while providing pain relief in osteoarthritis.

    • Jessica McHugh
    Research Highlight
  • Age-related B cells (ABCs) have pathogenic roles in autoimmune diseases. Research has now identified ZEB2 as the transcription factor that mediates differentiation into ABCs.

    • Robert Phillips
    Research Highlight
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News & Views

  • The identification of novel risk variants in the largest genome-wide association study of Raynaud phenomenon to date provides insights into the pathophysiology of the condition, including the potential role for α2A-adrenoceptors, and suggests opportunities for drug repurposing.

    • Ariane L. Herrick
    • Gisela Orozco
    News & Views
  • Re-establishing tolerance to autoantigens is an important aim for the treatment of rheumatoid arthritis (RA). Immunization of HLA-DR4 transgenic mice with citrullinated self-antigens can induce immune tolerance, which suggests that such antigens could have a therapeutic role in anti-citrullinated peptide antibody-positive RA.

    • Ranjeny Thomas
    • William H. Robinson
    News & Views
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Reviews

  • This Review discusses the interplay of the gut microbiome and the immune system in the context of systemic lupus erythematosus. Dysbiosis and gut-barrier dysfunction are implicated in promoting disease and are potential therapeutic targets.

    • Gregg J. Silverman
    • Doua F. Azzouz
    • Abhimanyu Amarnani
    Review Article
  • In this epidemiological Review, the authors summarize the available evidence relating to the prevalence, incidence, risk factors and mortality associated with the autoimmune disorder Sjögren syndrome, with or without the co-occurrence of other connective tissue diseases.

    • Maxime Beydon
    • Sara McCoy
    • Raphaèle Seror
    Review Article
  • Juvenile idiopathic arthritis treatment has evolved with new therapies, early remission goals and global efforts, including randomized trials and a treat-to-target strategy. This Review summarizes current evidence and therapeutic approaches to the management of non-systemic phenotypes of juvenile idiopathic arthritis.

    • Susan Shenoi
    • Gerd Horneff
    • Angelo Ravelli
    Review Article
  • Deep learning is a powerful technique with great potential for the analysis and interpretation of rheumatological images. To successfully use deep learning, rheumatologists should understand the tasks involved in image processing and the potential confounders and limitations that can affect the analysis of clinical data.

    • Berend C. Stoel
    • Marius Staring
    • Annette H. M. van der Helm-van Mil

    Collection:

    Review Article
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Amendments & Corrections

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