News & Comment

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  • New research has identified apolipoprotein E expressed by fibroblasts and macrophages in the infrapatellar fat pad and synovium as a pathogenetic mediator and potential therapeutic target in knee osteoarthritis.

    • Robert Phillips
    Research Highlight
  • Results of a new study indicate that eosinophils have a role in maintaining bone homeostasis through their inhibitory effects on bone-resorbing osteoclasts.

    • Sarah Onuora
    Research Highlight
  • Age-related B cells (ABCs) have pathogenic roles in autoimmune diseases. Research has now identified ZEB2 as the transcription factor that mediates differentiation into ABCs.

    • Robert Phillips
    Research Highlight
  • A meta-analysis of data from six genome-wide association study cohorts implicates several signalling pathways, including Hedgehog and Notch signalling, in Dupuytren disease.

    • Sarah Onuora
    Research Highlight
  • As in rheumatoid arthritis, achieving low disease activity or remission in psoriatic arthritis (PsA) remains a challenge and unmet need for many individuals. However, the complex pathogenesis, heterogeneity and varied tissue involvement in PsA mean that dedicated definitions and novel solutions are required for difficult-to-treat disease.

    • Stefan Siebert
    • Helena Marzo-Ortega
    Comment
  • New research has shown that tryptophan metabolism is altered in patients with rheumatoid arthritis, and that correction of this metabolic alteration has a protective effect against collagen-antibody-induced arthritis in mice.

    • Robert Phillips
    Research Highlight
  • Janus kinase inhibitors have therapeutic potential for patients with immune-mediated inflammatory diseases, and evidence of greater risks of cardiovascular disease and malignancy than with TNF inhibitors should be carefully considered before recommendations against their use are made. Assessment of the risk–benefit ratios in these patients can instead guide clinical decision-making.

    • Francesco Ciccia
    • Roberto Caporali
    Comment
  • New findings suggest that targeting the DAMP protein S100A4 could mitigate both inflammatory and fibrotic pathways in systemic sclerosis.

    • Jessica McHugh
    Research Highlight
  • In patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in sustained remission, reinfusion with rituximab after B cell repopulation resulted in fewer clinical relapses than did reinfusion following serological ANCA flare.

    • Sarah Onuora
    Research Highlight
  • A novel combination of ceria nanoparticles and mesenchymal stem cell nanovesicles modified both inflammation and autoimmunity in a mouse model of arthritis.

    • Robert Phillips
    Research Highlight
  • Globally, rheumatic musculoskeletal diseases constitute the most common causes of disability, related morbidity and economic loss worldwide. A shortage of rheumatologists warrants education of primary care doctors in primary care rheumatology, public awareness initiatives and advocacy for rheumatic musculoskeletal health.

    • Debashish Danda
    Comment
  • Using multi-omics analyses, researchers have identified two distinct immunological phenotypes of microscopic polyangiitis, which could inform prognosis and personalized treatment.

    • Sarah Onuora
    Research Highlight
  • New findings support the use of targeted next-generation sequencing of NOD2 to reassess the diagnosis of juvenile idiopathic arthritis in patients with signs and symptoms suggestive of Blau syndrome.

    • Sarah Onuora
    Research Highlight
  • Researchers have conducted a comprehensive single-cell analysis of synovial tissue in rheumatoid arthritis, providing insights into the heterogeneity of the disease and informing future treatment strategies.

    • Jessica McHugh
    Research Highlight
  • Methotrexate reduces pain and stiffness in hand osteoarthritis with synovitis, according to the results of a new randomized controlled trial.

    • Jessica McHugh
    Research Highlight