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The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Latest Reviews

  • Review Article |

    Neonatal cholestasis is a group of disorders of impaired bile flow characterized by conjugated hyperbilirubinaemia that can be fatal if not treated rapidly. In this Review, aetiologies, algorithms for evaluation and current and emerging therapeutic options for neonatal cholestasis are discussed.

    • Amy G. Feldman
    •  & Ronald J. Sokol
  • Review Article |

    Ganesh et al. describe the rationale for using immunotherapy in select patients with colorectal cancer, discuss clinical findings supporting its use and highlight current strategies and future directions for expanding the scope of immunotherapy in this disease.

    • Karuna Ganesh
    • , Zsofia K. Stadler
    • , Andrea Cercek
    • , Robin B. Mendelsohn
    • , Jinru Shia
    • , Neil H. Segal
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  • Review Article |

    Cholangiocytes, which line the intrahepatic and extrahepatic bile ducts, are specialized cells that regulate bile production and homeostasis. Here, the authors discuss the role of cholangiocytes in development and liver regeneration, inflammation and fibrosis and their interactions with the immune system.

    • Jesus M. Banales
    • , Robert C. Huebert
    • , Tom Karlsen
    • , Mario Strazzabosco
    • , Nicholas F. LaRusso
    •  & Gregory J. Gores
  • Review Article |

    Disease presentation and progression within and across IBD are highly heterogeneous, particularly in Crohn’s disease. Here, the authors summarize genomic, epigenomic and gut microbiota studies in adult and paediatric patients that have identified different IBD subtypes.

    • Terrence S. Furey
    • , Praveen Sethupathy
    •  & Shehzad Z. Sheikh
  • Review Article |

    Cancer-associated fibroblasts are critical components of the tumour mesenchyme. In this Review, the authors outline the emerging understanding of gastrointestinal cancer-associated fibroblasts with a particular emphasis on their origin and heterogeneity, as well as their function in cancer biology.

    • Hiroki Kobayashi
    • , Atsushi Enomoto
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    • , Alastair D. Burt
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News & Comment

Series

NAFLD and NASH

Caio Bracey

NAFLD and NASH

Fuelled by increasing obesity rates, NAFLD has emerged as a leading global cause of chronic liver disease in the past few decades. Despite growing prevalence, the factors influencing NAFLD development and subsequent progression to NASH, liver fibrosis, cirrhosis and hepatocellular carcinoma are poorly understood. In this article series, Nature Reviews Gastroenterology & Hepatology explores the epidemiology of NAFLD, disease mechanisms and therapeutics, and clinical approaches to diagnosis and management.

Hugh Thomas

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