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Cells dispose of cytoplasmic mitochondrial DNA by nucleoid-phagy
Mitochondrial damage in stress conditions results in the release of mitochondrial DNA (mtDNA), causing inflammation that is linked to various diseases. We discovered a mechanism for the elimination of this harmful mtDNA — ‘nucleoid-phagy’. Targeting this process represents another way to treat mitochondrial damage-related diseases.
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Celebrating 25 years of cell biology
2024 marks twenty five years since the launch of Nature Cell Biology.