Images: Jakub Wagner. Design: Carl Conway

Gazing into chemical space

Machine learning approaches that have their roots in quantum mechanics help us to navigate the complexity of chemical space and quickly predict new, unknown molecules.

Latest Reviews

  • Perspective |

    Iron–sulfur enzymes catalyse multielectron redox reactions in nature. This Perspective describes the in vitro methodologies by which we study these enzyme biosyntheses and compares the way in which different active sites are constructed.

    • R. David Britt
    • , Guodong Rao
    •  & Lizhi Tao
  • Review Article |

    Tagging and manipulating biomolecules in living systems requires precisely tuned, biocompatible reactions. This Review focuses on recent advances in the development of bioorthogonal reactions, with an emphasis on how mechanistic insights have driven the field.

    • Sean S. Nguyen
    •  & Jennifer A. Prescher
  • Review Article |

    Although amino acid repeats have been linked to a diverse range of diseases, they are prevalent in the human proteome. This Review describes their physiological importance, the factors that influence their conformations and therapeutic strategies to treat repeat-related diseases.

    • Sreenivas Chavali
    • , Anjali K. Singh
    • , Balaji Santhanam
    •  & M. Madan Babu
  • Review Article |

    Enhanced chemical reactivity on-water has major implications in many fields, ranging from atmospheric to prebiotic chemistry. This Review analyses recent experimental and theoretical studies in this fast-moving research area and brings together some key findings across diverse fields.

    • Manuel F. Ruiz-Lopez
    • , Joseph S. Francisco
    • , Marilia T. C. Martins-Costa
    •  & Josep M. Anglada
  • Review Article |

    RNA-binding proteins have crucial roles in cellular activities, and disruption of their function is associated with human diseases. This Review describes inhibition of RNA-binding proteins using small molecules as a rapidly evolving strategy for the discovery of chemical probes and therapeutics.

    • Peng Wu

News & Comment

  • Research Highlight |

    Vibronic coherences can guide a synthetic control of the lifetime of the excited states in iron(ii)-based complexes.

    • Gabriella Graziano
  • Research Highlight |

    Experimental models show that through-space effects dominate over through-bond effects when considering the influence of so-called electron-withdrawing or electron-donating substituents on molecular conformation and reactivity.

    • Stephen G. Davey
  • Research Highlight |

    Although they are generally poor coupling agents under palladium catalysis, germanes are easily cross-coupled under gold catalysis, enabling a new orthogonal cross-coupling reaction.

    • Stephen G. Davey
  • Research Highlight |

    Abiotic sources of H2 in the lithosphere outweigh the sinks, with the balance potentially being available to a large microbial community.

    • David Schilter
  • Research Highlight |

    Despite their similarity with surfactants, the mechanism by which hydrotropes assist in solubilizing apolar molecules in water is not totally understood. A mechanism is now proposed that identifies apolar interactions as driving forces of hydrotropy, in agreement with a statistical thermodynamic picture.

    • Gabriella Graziano

Collection

Perovskites for Optoelectronics

Perovskite materials have become very promising candidates for a new generation of potentially printable and efficient optoelectronic devices. Photovoltaic devices based on hybrid perovskites now achieve more than 20% photoconversion efficiency, and applications in solid-state lighting, photodetection and lasing are soaring. Their optoelectronic and photophysical properties are under intense scrutiny. This web-collection brings together a selection of multi-disciplinary research and comments published in the Nature journals that explores the basic properties of halide-based perovskite materials and their potential for application in optoelectronics, from solar cells to lasers. It serves to illustrate the road to easily processable and efficient devices by presenting both historical milestones and the crucial landmark studies published in the last 12 months in the Nature journals.