Cutting-edge chemistry is often performed in non-atmospheric conditions. Continued development of the Chemputer platform now enables the utilization of sensitive compounds in automated synthetic protocols.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wilbraham, L., Mehr, S. H. M. & Cronin, L. Digitizing chemistry using the chemical processing unit: From synthesis to discovery. Acc. Chem. Res. 54, 253–262 (2021).
Olsen, K. The first 110 years of laboratory automation: Technologies, applications, and the creative scientist. J. Lab. Autom. 17, 469–480 (2012).
Stevens, T. Rapid and automatic filtration. Am. Chemist 6, 102 (1875).
Palkin, S., Murray, A. G. & Watkins, H. R. Automatic devices for extracting alkaloidal solutions. Ind. Eng. Chem. 17, 612–614 (1925).
Ferguson, B. Jr. Semiautomatic fractionation. A rapid analytical method. Ind. Eng. Chem. Anal. Ed. 14, 493–496 (1942).
Craig, L. C., Gregory, J. D. & Hausmann, W. Versatile laboratory concentration device. Anal. Chem. 22, 1462–1462 (1950).
Steiner, S. et al. Organic synthesis in a modular robotic system driven by a chemical programming language. Science 363, eaav2211 (2019).
Bell, N. L. et al. Autonomous execution of highly reactive chemical transformations in the Schlenkputer. Nat. Chem. Eng. 1, 180–189 (2024).
Malig, T. C., Yunker, L. P. E., Steiner, S. & Hein, J. E. Online high-performance liquid chromatography analysis of Buchwald–Hartwig aminations from within an inert environment. ACS Catal. 10, 13236–13244 (2020).
Kleoff, M., Schwan, J., Christmann, M. & Heretsch, P. A Modular, argon-driven flow platform for natural product synthesis and late-stage transformations. Org. Lett. 23, 2370–2374 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Mahjour, B.A., Coley, C.W. Automation of air-free synthesis. Nat Rev Chem (2024). https://doi.org/10.1038/s41570-024-00599-x
Published:
DOI: https://doi.org/10.1038/s41570-024-00599-x