Let's get radical

Once a rarely observed curiosity, radical-pairing interactions have become a major tool for the supramolecular assembly and control of elaborate mechanically-interlocked structures.


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  • Selective cross-coupling at either of two similar halide substituents in a dihalogenated substrate can be achieved by controlling the speciation of the active palladium catalyst.

    • Jamal A. Malik
    Research Highlight
  • It has so far proved difficult to characterize halogen bonds in solution. A new and simple approach is to use scalar coupling between atoms in a halogen bond donor as a measure of bond strengths with diverse acceptors.

    • David Schilter
    Research Highlight
  • Cementitious materials — not least their reinforcements — are prone to aerobic oxidation, followed by chloride and sulfate attack. These processes jeopardize structures, particularly those exposed to air and seawater.

    • Pania Newell
  • Locally activating prodrugs through targeted irradiation — a new concept for concurrent chemotherapy and radiotherapy.

    • Colette Whitfield
    Research Highlight
  • The Fenton and Fenton-like reactions feature in oxidative stress and are central to advanced oxidation technologies to remediate organic pollutants. The reactions are often simplistically taught to afford only hydroxyl radical as the active oxidant. Yet, this is just one of many possible oxidants and is probably not the major oxidant formed under biological conditions.

    • Dan Meyerstein
  • A polymer coating made from cosmetics-based ingredients can be applied to diverse surfaces to capture airborne droplets and mitigate the transmission of infectious respiratory diseases.

    • Claire Ashworth
    Research Highlight
Celebrating 15 Years of Covalent Organic Frameworks

Celebrating 15 Years of Covalent Organic Frameworks

This collection celebrates 15 years of research on covalent organic frameworks and highlights some of the contributions that were published in journals of the Nature Research portfolio. We hope you enjoy exploring these snippets on the synthesis and structure of COFs, their physical properties, and their application in fields encompassing energy, catalysis, storage and separation.
  • Johannes Kreutzer