David Unnersjoe-Jess. Cover Design: Thomas Phillips

The biophysical basis of kidney ultrafiltration

Latest Research

  • Article |

    Aregger et al. provide an approach to study genetic interactions in mammalian cells and describe genetic interaction maps that characterize genes involved in lipid metabolism. They identify the role of C12orf49, a previously uncharacterized gene, in regulating lipid uptake in human cells.

    • Michael Aregger
    • , Keith A. Lawson
    • , Maximillian Billmann
    • , Michael Costanzo
    • , Amy H. Y. Tong
    • , Katherine Chan
    • , Mahfuzur Rahman
    • , Kevin R. Brown
    • , Catherine Ross
    • , Matej Usaj
    • , Lucy Nedyalkova
    • , Olga Sizova
    • , Andrea Habsid
    • , Judy Pawling
    • , Zhen-Yuan Lin
    • , Hala Abdouni
    • , Cassandra J. Wong
    • , Alexander Weiss
    • , Patricia Mero
    • , James W. Dennis
    • , Anne-Claude Gingras
    • , Chad L. Myers
    • , Brenda J. Andrews
    • , Charles Boone
    •  & Jason Moffat
  • Letter |

    Bayraktar et al. construct a metabolic coessentiality network to cluster metabolic genes into networks from perturbation datasets derived from 558 cancer cell lines. They identify C12orf49 as an essential component of SREBP processing and cholesterol sensing in mammalian cells.

    • Erol C. Bayraktar
    • , Konnor La
    • , Kara Karpman
    • , Gokhan Unlu
    • , Ceren Ozerdem
    • , Dylan J. Ritter
    • , Hanan Alwaseem
    • , Henrik Molina
    • , Hans-Heinrich Hoffmann
    • , Alec Millner
    • , G. Ekin Atilla-Gokcumen
    • , Eric R. Gamazon
    • , Amy R. Rushing
    • , Ela W. Knapik
    • , Sumanta Basu
    •  & Kıvanç Birsoy
  • Letter |

    An automated decision support system is reported that provides weekly insulin dosage recommendations to users with T1D and that, when analysing previously collected patient data, exhibits high agreement with recommendations from physicians.

    • Nichole S. Tyler
    • , Clara M. Mosquera-Lopez
    • , Leah M. Wilson
    • , Robert H. Dodier
    • , Deborah L. Branigan
    • , Virginia B. Gabo
    • , Florian H. Guillot
    • , Wade W. Hilts
    • , Joseph El Youssef
    • , Jessica R. Castle
    •  & Peter G. Jacobs
  • Letter |

    Itaconate production is a hallmark of inflammatory activated macrophages. Swain et al. compare the biological effects of itaconate and its common derivatives, identifying a new regulatory mode of inhibiting IL-1β secretion and enhancing IFN-β signalling.

    • Amanda Swain
    • , Monika Bambouskova
    • , Hyeryun Kim
    • , Prabhakar Sairam Andhey
    • , Dustin Duncan
    • , Karine Auclair
    • , Victor Chubukov
    • , Donald M. Simons
    • , Thomas P. Roddy
    • , Kelly M. Stewart
    •  & Maxim N. Artyomov
  • Article |

    Thermogenic adipose tissue has been suggested as a potential target to treat metabolic diseases. Here, Tran et al. show that a long noncoding RNA, LINC00473, is induced during activation of thermogenic adipocytes and regulates energy metabolism through interorganelle communication.

    • Khanh-Van Tran
    • , Erin L. Brown
    • , Tiffany DeSouza
    • , Naja Zenius Jespersen
    • , Cecilie Nandrup-Bus
    • , Qin Yang
    • , Zinger Yang
    • , Anand Desai
    • , So Yun Min
    • , Raziel Rojas-Rodriguez
    • , Morten Lundh
    • , Amir Feizi
    • , Hanni Willenbrock
    • , Therese Juhlin Larsen
    • , Mai Charlotte Krogh Severinsen
    • , Kimberly Malka
    • , Anthony M. Mozzicato
    • , Atul S. Deshmukh
    • , Brice Emanuelli
    • , Bente Klarlund Pedersen
    • , Timothy Fitzgibbons
    • , Camilla Scheele
    • , Silvia Corvera
    •  & Søren Nielsen
  • Article |

    Currently, there is no approved treatment for NAFLD and NASH. Here, Boland et al. show that the GLP-1R and GCGR dual-agonist cotadutide reduces hepatic steatosis, inflammation and fibrosis via GCGR agonism, and glucose homeostasis and weight gain by activating GLP-1 signalling.

    • Michelle L. Boland
    • , Rhianna C. Laker
    • , Karly Mather
    • , Arkadiusz Nawrocki
    • , Stephanie Oldham
    • , Brandon B. Boland
    • , Hilary Lewis
    • , James Conway
    • , Jacqueline Naylor
    • , Silvia Guionaud
    • , Michael Feigh
    • , Sanne S. Veidal
    • , Louise Lantier
    • , Owen P. McGuinness
    • , Joseph Grimsby
    • , Cristina M. Rondinone
    • , Lutz Jermutus
    • , Martin R. Larsen
    • , James L. Trevaskis
    •  & Christopher J. Rhodes

News & Comment

  • Obituary |

    We have lost a distinguished biochemist who dedicated his career to the study of phosphatidylinositol signalling in metabolic regulation and to the advancement of lipidomics.

    • Friedrich Spener
    • , Christian Wolfrum
    •  & Wolf Reik
  • News & Views |

    Whereas textbooks depict metabolism in perfect homeostasis, disturbances occur in real life. One particularly relevant disturbance, caused by excess food and alcohol consumption and exacerbated by genetics, is reductive stress. New work by Goodman et al. identifies a biomarker of reductive stress and uses a gene therapy solution in mice. This work suggests how exercise and an accessible nutritional technology can synergistically increase catabolism and relieve reductive stress.

    • Collin D. Heer
    •  & Charles Brenner
  • News & Views |

    Thermogenic adipocytes can burn lipids and carbohydrates for heat generation. The finding that a primate-specific long non-coding RNA regulates lipolysis and respiration in thermogenic adipocytes reveals a new mechanism controlling thermogenic adipocyte metabolism in humans.

    • Dan Xu
    •  & Lei Sun
  • Comment |

    As the metabolism community has grown and diversified with scientists from multidisciplinary backgrounds, metabolic terminology has evolved and expanded. In this Comment, we reflect on this new vernacular and how established terminology can guide future discussions of metabolic research.

    • Mary-Ellen Harper
    •  & Mary-Elizabeth Patti
  • News & Views |

    Exposure to high glucose under inflammatory conditions is detrimental to insulin-secreting beta cells in the pancreas. Fu and colleagues describe a metabolic axis that decreases production of the ‘danger molecule’ nitric oxide and improves the survival of beta cells exposed to an inflammatory milieu, thus paving the way to new interventions for diabetes.

    • Christian Frezza