liver cells

Asters maintain cholesterol homeostasis

  • Xu Xiao
  • John Paul Kennelly
  • Peter Tontonoz


  • Person surrounded by brain cells and neurocircuits

    This Focus brings together a selection of Reviews, Perspectives and related research that integrate the most recent advances in our understanding of how the brain controls energy homeostasis. This is presented both from a neurocircuit perspective describing the initiation or cessation of eating, as well as from a more detailed view of how these processes occur at the cellular level.

  • Crossing arrows

    The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors.

  • science lab

    This Collection highlights best practices in experimental design, analysis, and reporting to support the metabolic research community and increase reproducibility of research in the life sciences

  • a fly, a worm, and a fish

    This growing web collection features research articles published in Nature Metabolism that make use of non-mammalian model organisms. With this collection we aim to highlight the usefulness of these models for unraveling new metabolic biology.

Nature Metabolism is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


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    • Intracellular trafficking of cholesterol is essential for its uptake, storage and export. In this issue of Nature Metabolism, Xiao et al. provide powerful evidence for the importance of hepatic GRAMD1/Aster transporters in maintaining systemic cholesterol homeostasis.

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