Metabolic brakes of SARS-CoV-2 replication

  • Junjun Chu
  • Changsheng Xing
  • Rong-Fu Wang
Letter

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    • Zechner and colleagues discuss mechanisms facilitating the mobilization of intracellular fatty acids and how they affect lipid-mediated signalling, metabolic regulation and energy homeostasis in health and disease.

      • Gernot F. Grabner
      • Hao Xie
      • Rudolf Zechner
      Review Article
    • Two studies unmask the essentiality of methionine synthase activity in powering the folate cycle to replenish the tetrahydrofolate pool from 5-methyltetrahydrofolate; this generates nucleotides that support tumour growth. Dietary manipulation alters folate availability and holds implications for anti-cancer therapy response.

      • Zhengwei Wu
      • Wai Leong Tam
      News & Views
    • Immune cells can promote the thermogenic phenotype of white adipocytes during cold exposure, in a process known as ‘browning’ or ‘beiging’. Wang et al. now reveal a potential mechanism whereby alternatively activated macrophages prompt adipose sympathetic nerve fibres to release norepinephrine and promote adipocyte beiging.

      • Michael P. Czech
      News & Views
    • Alterations to the extracellular matrix have long been associated with cancer progression and therapeutic resistance. Schwörer et al. describe a mechanism whereby fibroblasts reroute metabolites to fuel the demands of collagen synthesis, leading to cancer progression.

      • Zachary A. Bacigalupa
      • W. Kimryn Rathmell
      News & Views
    • A recent study shows how hyperinsulinaemia in obesity unexpectedly activates the cell cycle of overworked mature adipocytes in a process known as endo-reduplication, which represents a ‘last gasp’ strategy to remain functionally competent. However, this strategy fails and triggers premature senescence and tissue dysfunction.

      • Sergio Rodriguez-Cuenca
      • Antonio Vidal-Puig
      News & Views
  • Discovering that a different lab has reached similar findings to yours before publishing can be frustrating. But it does not have to be. Communication between labs might be the best way forward.

    Editorial
  • How to adjust metabolic rate (MR) in mice that differ in body mass and composition continues to lead to controversies. Here, the challenges that reside in the analysis of mouse MR are highlighted to spur consensus on the unequivocal use of regression-based analysis to maximize reliability and relevance of conclusions.

    • Timo D. Müller
    • Martin Klingenspor
    • Matthias H. Tschöp
    Comment
  • Although the COVID-19 pandemic brought the conference circuit to a standstill, virtual spaces were able to bring us together, albeit with less opportunity for social bonding. Taking clues from the technology and entertainment industries, virtual scientific conference organizers should offer a more meaningful social experience.

    Editorial
  • Diabetes therapeutic approaches continue to expand and to be refined. As the field moves toward more intensive insulin- and cell-based therapies, care must be taken to mimic healthy physiological insulin dynamics and avoid hyperinsulinemia, with its deleterious downstream complications.

    • Jelena Kolic
    • James D. Johnson
    Comment