Intestinal maladaptation in obesity

  • Alexandra Aliluev
  • Sophie Tritschler
  • Anika Böttcher


  • Originally scheduled for publication in time for the 2020 Summer Olympic Games, we bring you a special focus on exercise metabolism and health, consisting of Reviews and Commentary revisiting foundational topics and highlighting new paradigms in exercise and muscle metabolism, as well as their broader implications for organismal health.

  • The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors.

Nature Metabolism is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


    • In this study, the serine biosynthetic enzyme PHGDH is shown to transition from the cytosol to the nucleus following nutrient stress. Nuclear PHGDH reduces local NAD+ availability needed for the PARylation of the transcription factor c-Jun. Consequently, c-Jun activity is reduced, contributing to sustained cancer cell proliferation.

      • Daniela Annibali
      • Sarah-Maria Fendt
      News & Views
    • Dysfunctional efferocytosis impairs clearance of apoptotic cells in disease. A new study shows that glutamine catabolism supports efficient apoptotic cell efferocytosis via non-canonical glutamine transamination but not canonical GLUD1-dependent α-ketoglutarate production, in a process that may operate in human atherosclerosis.

      • Alison Jaccard
      • Xiaoyun Li
      • Ping-Chih Ho
      News & Views
    • The fasting-mimicking diet is a five-day cycle of near total fasting each month that extends healthspan in male mice. In this issue of Nature Metabolism, Mishra et al. demonstrate life-extending and cardioprotective benefits of the fasting-mimicking diet in middle-aged female mice that are consuming a high-fat diet.

      • Leonie K. Heilbronn
      News & Views
    • Tumour necrosis factor is a classical pro-inflammatory cytokine. Sethi and Hotamisligil provide a comprehensive overview of its pleiotropic immunometabolic actions, while presenting a framework that is applicable to the complex network of other pro-inflammatory signals and their relevance to metabolic diseases such as obesity and diabetes.

      • Jaswinder K. Sethi
      • Gökhan S. Hotamisligil
      Metabolic Messengers
  • How to adjust metabolic rate (MR) in mice that differ in body mass and composition continues to lead to controversies. Here, the challenges that reside in the analysis of mouse MR are highlighted to spur consensus on the unequivocal use of regression-based analysis to maximize reliability and relevance of conclusions.

    • Timo D. Müller
    • Martin Klingenspor
    • Matthias H. Tschöp
  • Although the COVID-19 pandemic brought the conference circuit to a standstill, virtual spaces were able to bring us together, albeit with less opportunity for social bonding. Taking clues from the technology and entertainment industries, virtual scientific conference organizers should offer a more meaningful social experience.

  • Diabetes therapeutic approaches continue to expand and to be refined. As the field moves toward more intensive insulin- and cell-based therapies, care must be taken to mimic healthy physiological insulin dynamics and avoid hyperinsulinemia, with its deleterious downstream complications.

    • Jelena Kolic
    • James D. Johnson
  • Since the publication of its first issue in January 2019, Nature Metabolism has come a long way. Here, we reflect on watching our journal develop and grow, highlighting some of the important milestones on our journey.