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Intravascularly infused extracellular matrix from ventricular myocardium binds to leaky vasculature and induces the regeneration of inflamed heart tissue, as shown in rats and pigs.
This Perspective overviews the sources of prediction uncertainty in machine learning for applications in healthcare, and discusses how to implement suitable prediction-uncertainty metrics.
Antitumour responses mediated by T helper 17 cells can be induced by intratumourally injected hollow nanoparticles displaying the polysaccharide mannan.
Graph neural networks and transformers taking advantage of contextual information and large unannotated multimodal datasets are redefining what is possible in computational medicine.
Each of the 13 protein-coding genes in the mouse mitochondrial genome can be ablated using a library of optimized double-stranded-DNA deaminase-derived cytosine base editors.
Intra-tumourally injected hollow nanoparticles displaying the polysaccharide mannan downregulate the fraction of regulatory T cells in the tumour microenvironment and induce anti-tumour responses mediated by T helper 17 cells.
A deep-learning model that transforms cryosectioned whole-slide tissue images into the style of whole-slide formalin-fixed and paraffin-embedded tissue improves the rates of accurate tumour subtyping.
The targeted delivery of the short-chain fatty acid butyrate to the lower gastrointestinal tract by polymeric nanoscale micelles restores intestinal homeostasis in mouse models of peanut allergy and colitis.
Liposomal nanoparticles incorporating photosensitive lipids and enclosing paramagnetic molecules enable the mapping, via magnetic resonance imaging, of spatial variations of light intensity in illuminated brain tissue in living animals.
Light in deep tissue can be spatially mapped via magnetic resonance imaging by leveraging liposomal nanoparticles incorporating photosensitive lipids and enclosing paramagnetic molecules.
Nanoparticles producing ultrasound-induced afterglow luminescence in the presence of a tumour biomarker allow for the image-guided treatment of mice bearing subcutaneous tumours.
A peritumourally implanted macroporous scaffold releasing small molecules and antibodies to suppress regulatory T cells and to attract and stimulate effector T cells enhanced endogenous antitumoural responses in mice bearing aggressive tumours.
This Review highlights technological advances in exoskeleton technology from the past two decades, and challenges and opportunities in the exoskeleton-assisted rehabilitation of gait.
Intragastrically delivered polymeric micelles releasing butyrate along the intestinal tract restore barrier-protective responses in mouse models of peanut allergy and colitis.
Pooled testing for the diagnosis of COVID-19 via isothermal nucleic acid amplification and detection can be automated by using electromagnetically actuated swarms of millimetric magnets to handle droplets of magnetized samples on a microfluidic chip.
Hepatobiliary MRI can be enhanced by an ultrasmall nanoparticle composed of a manganese ferrite core and surface ligands binding to hepatocyte-specific transmembrane metal and anion transporters, as shown in small and large animals.
A caller of genomic variants that, by leveraging machine-learning classifiers, reduces read-mapping costs by filtering out reads matched to pan-genome k-mer sets outperforms popular variant callers in the detection of somatic structural variations.