Browse Articles

  • Article |

    An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

    • Canan Dagdeviren
    • , Farhad Javid
    • , Pauline Joe
    • , Thomas von Erlach
    • , Taylor Bensel
    • , Zijun Wei
    • , Sarah Saxton
    • , Cody Cleveland
    • , Lucas Booth
    • , Shane McDonnell
    • , Joy Collins
    • , Alison Hayward
    • , Robert Langer
    •  & Giovanni Traverso
  • Perspective |

    This Perspective discusses recent technological developments in flow cytometry and DNA sequencing that enable the interrogation of T-cell specificities in infection, cancer and autoimmunity to inform disease development and treatment.

    • Sine Reker Hadrup
    •  & Evan W. Newell
  • News and Views |

    The genetic, epigenetic and transcriptomic profiles of human-induced pluripotent stem cells are shaped by the reprogramming route.

    • Thomas F. Allison
    •  & William E. Lowry
  • News and Views |

    Light-sheet microscopy reveals 3D tumour heterogeneity in optically cleared paraffin-embedded tumour samples.

    • Boyan K. Garvalov
    •  & Ali Ertürk
  • News and Views |

    Flexible piezoelectric sensors can detect mechanical deformations in the gastrointestinal tract of ambulating pigs and simultaneously harvest energy from it.

    • Ghazaleh Haghiashtiani
    •  & Michael C. McAlpine
  • Article |

    A fluorescence-based assay is used to screen cyclic peptides for their activity in preventing protein misfolding, an event that can generate pathogenic aggregates that lead to diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.

    • Ilias Matis
    • , Dafni Chrysanthi Delivoria
    • , Barbara Mavroidi
    • , Nikoletta Papaevgeniou
    • , Stefania Panoutsou
    • , Stamatia Bellou
    • , Konstantinos D. Papavasileiou
    • , Zacharoula I. Linardaki
    • , Alexandra V. Stavropoulou
    • , Kostas Vekrellis
    • , Nikos Boukos
    • , Fragiskos N. Kolisis
    • , Efstathios S. Gonos
    • , Marigoula Margarity
    • , Manthos G. Papadopoulos
    • , Spiros Efthimiopoulos
    • , Maria Pelecanou
    • , Niki Chondrogianni
    •  & Georgios Skretas
  • News and Views |

    High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases.

    • Tobias Langenberg
    • , Joost Schymkowitz
    •  & Frederic Rousseau
  • Editorial |

    When reading or writing about biomedical findings, be mindful of factual accuracy and wary of unapparent caveats.

  • News and Views |

    Devices made with resorbable polymers and braided materials can accommodate tissue growth in long-bone and heart-valve animal models.

    • Scott J. Hollister
  • Article |

    An implantable device consisting of a biodegradable core and a tubular braided sleeve autonomously elongates to accommodate tissue growth, as shown with prototypes implanted on a rat tibial bone and a piglet heart valve.

    • Eric N. Feins
    • , Yuhan Lee
    • , Eoin D. O’Cearbhaill
    • , Nikolay V. Vasilyev
    • , Shogo Shimada
    • , Ingeborg Friehs
    • , Douglas Perrin
    • , Peter E. Hammer
    • , Haruo Yamauchi
    • , Gerald Marx
    • , Andrew Gosline
    • , Veaceslav Arabagi
    • , Jeffrey M. Karp
    •  & Pedro J. del Nido
  • Article |

    The expression of two specific DNA-repair factors promotes homology-directed repair and enhances the precision of CRISPR–Cas9 gene editing at multiple loci in human cells, including patient-derived induced pluripotent stem cells.

    • Bruna S. Paulsen
    • , Pankaj K. Mandal
    • , Richard L. Frock
    • , Baris Boyraz
    • , Rachita Yadav
    • , Srigokul Upadhyayula
    • , Paula Gutierrez-Martinez
    • , Wataru Ebina
    • , Anders Fasth
    • , Tomas Kirchhausen
    • , Michael E. Talkowski
    • , Suneet Agarwal
    • , Frederick W. Alt
    •  & Derrick J. Rossi
  • Article |

    Epigenetic and transcriptomic differences in human induced pluripotent stem cells generated from the same fibroblast population reveals that the reprogramming method affects the cells’ gene-expression levels but not their differentiation potential.

    • Jared M. Churko
    • , Jaecheol Lee
    • , Mohamed Ameen
    • , Mingxia Gu
    • , Meenakshi Venkatasubramanian
    • , Sebastian Diecke
    • , Karim Sallam
    • , Hogune Im
    • , Gavin Wang
    • , Joseph D. Gold
    • , Nathan Salomonis
    • , Michael P. Snyder
    •  & Joseph C. Wu
  • Article |

    A method that identifies patterns of tumour heterogeneity in intact biopsy samples using 3D light-sheet microscopy stratifies patients by tumour stage.

    • Nobuyuki Tanaka
    • , Shigeaki Kanatani
    • , Raju Tomer
    • , Cecilia Sahlgren
    • , Pauliina Kronqvist
    • , Dagmara Kaczynska
    • , Lauri Louhivuori
    • , Lorand Kis
    • , Claes Lindh
    • , Przemysław Mitura
    • , Andrzej Stepulak
    • , Sara Corvigno
    • , Johan Hartman
    • , Patrick Micke
    • , Artur Mezheyeuski
    • , Carina Strell
    • , Joseph W. Carlson
    • , Carlos Fernández Moro
    • , Hanna Dahlstrand
    • , Arne Östman
    • , Kazuhiro Matsumoto
    • , Peter Wiklund
    • , Mototsugu Oya
    • , Ayako Miyakawa
    • , Karl Deisseroth
    •  & Per Uhlén
  • Article |

    Gold nanoparticles carrying Cas9 ribonucleoprotein and donor DNA, and complexed with endosomal disruptive polymers, correct the DNA mutation that causes Duchenne muscular dystrophy in mice, with minimal off-target effects.

    • Kunwoo Lee
    • , Michael Conboy
    • , Hyo Min Park
    • , Fuguo Jiang
    • , Hyun Jin Kim
    • , Mark A. Dewitt
    • , Vanessa A. Mackley
    • , Kevin Chang
    • , Anirudh Rao
    • , Colin Skinner
    • , Tamanna Shobha
    • , Melod Mehdipour
    • , Hui Liu
    • , Wen-chin Huang
    • , Freeman Lan
    • , Nicolas L. Bray
    • , Song Li
    • , Jacob E. Corn
    • , Kazunori Kataoka
    • , Jennifer A. Doudna
    • , Irina Conboy
    •  & Niren Murthy
  • News and Views |

    Causing nanoscale vibrations in bone-marrow stromal cells embedded in a soft collagen gel induces the cells to undergo osteogenic differentiation and mineralization via mechanosensitive signalling pathways.

    • Jeroen Eyckmans
    •  & Christopher S. Chen
  • News and Views |

    A dendrimer that depletes bioavailable copper as a result of its internal make-up displays powerful anticancer activity in mice, and no observable adverse effects.

    • Zhenbin Lyu
    •  & Ling Peng
  • Review Article |

    This Review discusses imaging approaches that benefit from the combination of signals and modalities to enhance patient diagnosis and the monitoring of therapy.

    • Kathrin Heinzmann
    • , Lukas M. Carter
    • , Jason S. Lewis
    •  & Eric O. Aboagye
  • Article |

    Nanoscale vibrations provided by a bioreactor induce the differentiation of mesenchymal stem cells into mineralized tissue in three dimensions, independently of other environmental factors.

    • Penelope M. Tsimbouri
    • , Peter G. Childs
    • , Gabriel D. Pemberton
    • , Jingli Yang
    • , Vineetha Jayawarna
    • , Wich Orapiriyakul
    • , Karl Burgess
    • , Cristina González-García
    • , Gavin Blackburn
    • , Dilip Thomas
    • , Catalina Vallejo-Giraldo
    • , Manus J. P Biggs
    • , Adam S. G. Curtis
    • , Manuel Salmerón-Sánchez
    • , Stuart Reid
    •  & Matthew J. Dalby
  • News and Views |

    Laser light emitted by fluorescently stained human tissue inside a laser cavity can be used to diagnose cancer.

    • Matjaž Humar
  • Comment |

    Interventional healthcare will evolve from an artisanal craft based on the individual experiences, preferences and traditions of physicians into a discipline that relies on objective decision-making on the basis of large-scale data from heterogeneous sources.

    • Lena Maier-Hein
    • , Swaroop S. Vedula
    • , Stefanie Speidel
    • , Nassir Navab
    • , Ron Kikinis
    • , Adrian Park
    • , Matthias Eisenmann
    • , Hubertus Feussner
    • , Germain Forestier
    • , Stamatia Giannarou
    • , Makoto Hashizume
    • , Darko Katic
    • , Hannes Kenngott
    • , Michael Kranzfelder
    • , Anand Malpani
    • , Keno März
    • , Thomas Neumuth
    • , Nicolas Padoy
    • , Carla Pugh
    • , Nicolai Schoch
    • , Danail Stoyanov
    • , Russell Taylor
    • , Martin Wagner
    • , Gregory D. Hager
    •  & Pierre Jannin
  • News and Views |

    Microchips embedding a magnetic sensor and a radiofrequency transmitter can be localized in the body of a mouse at submillimetre resolution when under a magnetic field.

    • Yong Lin Kong
    •  & Giovanni Traverso