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Towards on-skin analysis of sweat for managing disorders of substance abuse

Nature Biomedical Engineering (2024)Cite this article

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A patient-centred system that leverages the analysis of sweat via wearable sensors may better support the management of patients with substance-use disorders.

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Fig. 1: Wearable sweat analysis for the management of SUDs.

References

  1. Mojtabai, R. JAMA Psychiatry 79, 1074–1080 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Guliyev, C., İnce-Guliyev, E. & Ögel, K. J. Psychoact. Drugs 54, 358–367 (2022).

    Article  Google Scholar 

  3. Baker, L. B. et al. Sci. Adv. 6, eabe3929 (2020).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  4. Brasier, N. et al. Lancet Infect. Dis. 23, E445–E453 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Volkow, N. D., Michaelides, M. & Baler, R. Physiol. Rev. 99, 2115–2140 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lüscher, C. & Ungless, M. A. PLoS Med. 3, e437 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Keiflin, R. & Janak, P. H. Neuron 88, 247–263 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lüscher, C. & Janak, P. H. Annu. Rev. Neurosci. 44, 173–195 (2021).

    Article  PubMed  Google Scholar 

  9. Smith, C. J. & Havenith, G. Med. Sci. Sports Exerc. 44, 2350–2361 (2012).

    Article  PubMed  Google Scholar 

  10. Havenith, G., Fogarty, A., Bartlett, R., Smith, C. J. & Ventenat, V. Eur. J. App. Physiol. 104, 245–255 (2008).

    Article  Google Scholar 

  11. Baker, L. B. et al. Physiol. Rep. 8, e14524 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Morris, N. B., Cramer, M. N., Hodder, S. G., Havenith, G. & Jay, O. J. Appl. Physiol. 114, 816–823 (2013).

    Article  PubMed  Google Scholar 

  13. Foster, J., Hodder, S. G., Lloyd, A. B. & Havenith, G. Front. Physiol. 11, 541483 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Brasier, N. & Eckstein, J. Digit. Biomark. 3, 155–165 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Hudson, M. et al. J. Anal. Toxicol. 43, 88–95 (2019).

    Article  CAS  PubMed  Google Scholar 

  16. Biscay, J., Findlay, E. & Dennany, L. Talanta 224, 121815 (2021).

    Article  CAS  PubMed  Google Scholar 

  17. Jagannath, B. et al. Bioeng. Transl. Med. 6, e10220 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Min, J. et al. Chem. Rev. 123, 5049–5138 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Kim, J., Campbell, A. S., de Ávila, B. E. & Wang, J. Nat. Biotechnol. 37, 389–406 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Bariya, M., Nyein, H. Y. Y. & Javey, A. Nat. Electron. 1, 160–171 (2018).

    Article  Google Scholar 

  21. Wang, M. et al. Nat. Biomed. Eng. 6, 1225–1235 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Tu, J. et al. Nat. Biomed. Eng. 7, 1293–1306 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Nyein, H. Y. Y. et al. Nat. Commun. 12, 1823 (2021).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  24. Francis, J., Stamper, I., Heikenfeld, J. & Gomez, E. F. Lab Chip 19, 178–185 (2018).

    Article  PubMed  Google Scholar 

  25. Kwon, K. et al. Nat. Electron. 4, 302–312 (2021).

    Article  Google Scholar 

  26. Sempionatto, J. R. et al. Nat. Biomed. Eng. 5, 737–748 (2021).

    Article  CAS  PubMed  Google Scholar 

  27. Sempionatto, J. R., Lasalde-Ramírez, J. A., Mahato, K., Wang, J. & Gao, W. Nat. Rev. Chem. 6, 899–915 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  28. Ethirajan, P., Simiyon, M. & Thilakan, P. BJPsych Open 8, S72 (2022).

    Article  PubMed Central  Google Scholar 

  29. Coull, N. A., West, A. M., Hodder, S. G., Wheeler, P. & Havenith, G. Eur. J. Appl. Physiol. 121, 109–125 (2021).

    Article  PubMed  Google Scholar 

  30. van Brummelen, E. M. J. et al. J. Clin. Mov. Disord. 7, 4 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  31. Kolcu, M. İ. B. & Kolcu, G. in Health 4.0 and Medical Supply Chain (eds İyigün, İ. & Görçün, Ö. F.) 109–119 (Springer, 2023).

  32. Geissler, J., Ryll, B., di Priolo, S. L. & Uhlenhopp, M. Ther. Innov. Regul. Sci. 51, 612–619 (2017).

    Article  PubMed  Google Scholar 

  33. Jacob, C., Bourke, S. & Heuss, S. JMIR Hum. Factors 9, e41481 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  34. Grinberg, C., Hawthorne, M., LaNoue, M., Brenner, J. & Mautner, D. Popul. Health Manag. 19, 248–256 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  35. Hardin, L., Trumbo, S. & Wiest, D. J. Interprofess. Ed. Pract. 18, 100291 (2020).

    Article  Google Scholar 

  36. Principles of Drug Addition Treatment: A Research-Based Guide (Third Edition) (National Institute on Drug Abuse, 2018); https://go.nature.com/49ZfawQ

  37. Drobes, D. J. & Thomas, S. E. Alcohol Res. Health 23, 179–186 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

N.B. acknowledges a MedLab Fellowship from ETH Zurich and an Early-Career Fellowship from Collegium Helveticum, Zurich. W.G. acknowledges support from the National Science Foundation Grant 2145802, the American Cancer Society Research Scholar Grant RSG-21-181-01-CTPS and the Center for Sensing to Intelligence at the California Institute of Technology. We thank A. Curtis for language editing.

Author information

Authors and Affiliations

  1. Institute of Translational Medicine, Department of Health Science and Technology, ETH Zurich, Zurich, Switzerland

    Noe Brasier & Jörg Goldhahn

  2. Collegium Helveticum, Zurich, Switzerland

    Noe Brasier

  3. Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA

    Juliane R. Sempionatto & Wei Gao

  4. PersonalPulse GmbH, Arlesheim, Switzerland

    Steven Bourke

  5. Environmental Ergonomics Research Centre, Loughborough Design School, Loughborough University, Loughborough, UK

    George Havenith

  6. Digital Trial Intervention Platform, ETH Zurich, Baden, Switzerland

    Dietmar Schaffarczyk

  7. Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland

    Christian Lüscher

  8. Clinic of Neurology, Department of Clinical Neurosciences, Geneva University Hospital, Geneva, Switzerland

    Christian Lüscher

Authors
  1. Noe Brasier
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  2. Juliane R. Sempionatto
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  3. Steven Bourke
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  4. George Havenith
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  5. Dietmar Schaffarczyk
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  6. Jörg Goldhahn
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  7. Christian Lüscher
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  8. Wei Gao
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Contributions

All authors contributed to the writing of the manuscript. N.B. organized the project and facilitated inclusive discussions among all authors.

Corresponding author

Correspondence to Noe Brasier.

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The authors declare no competing interests.

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Nature Biomedical Engineering thanks Drew Hall, Kuniharu Takei and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Brasier, N., Sempionatto, J.R., Bourke, S. et al. Towards on-skin analysis of sweat for managing disorders of substance abuse. Nat. Biomed. Eng (2024). https://doi.org/10.1038/s41551-024-01187-6

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