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Environmental enrichment is a home-based intervention that mimics natural habitats for laboratory-housed animals. This systematic review of 27 environmental enrichment protocols finds consistent benefits for zebrafish welfare while raising the importance of a standardizing protocol to improve reproducibility of results.
Fernandez, Martinez-Romero et al. review concepts, methods, tools and challenges to leverage Big Data in preclinical aging research, with a focus on rodent studies.
The authors used a gene-editing approach to generate a C57BL/6J mouse model expressing the CD45.1 epitope. The model, which overcomes some of the issues reported with the congenic mouse B6.SJL, could be useful for adoptive cell transfer experiments.
The authors present a simultaneous PET/MR dataset of 20 Macaca fascicularis images structured according to the Brain Imaging Data Structure standards. The PREMISE database is stored and available through the PRIME-DE consortium repository.
The authors show that VAR2CSA-based placental malaria vaccine candidates induce similar responses in Aotus nancymaae monkeys as those reported in humans; these findings suggest that the Aotus model is suitable for preclinical downselection of placental malaria vaccine candidates.