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Comment |
When is a lab animal not a lab animal?
Rehabilitation of tumor-afflicted sea turtles, and their utilization as a natural model for human and wildlife cancers.
- David J. Duffy
- & Brooke Burkhalter
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Research Highlight |
Flu from the nose: influenza A is spread from the upper respiratory tract of ferrets
- Ellen P. Neff
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Research Highlight |
In vivo glia-to-neuron conversion corrects Huntington’s disease in mice
- Alexandra Le Bras
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News & Views |
Somatic base editing to model oncogenic drivers in breast cancer
Human cancer is a disease of cooperating genetic events that is complex to model in vivo. A new study combines somatic base editing with a mouse model of breast cancer, demonstrating the potential to rapidly investigate the function of disease-specific point mutations.
- Kirsteen J. Campbell
- & Karen Blyth
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Technology Feature |
Get a look at Galleria
As researchers look for more mammalian alternatives, an old moth is learning new tricks.
- Jim Kling
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Protocol Review |
The Department Chair could have done better…
- Sally Thompson-Iritani
- , Nicholas Reyes
- & Jane M. Sullivan
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In This Issue |
In this issue
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Protocol Review |
No way to build a relationship…unless animosity is your goal
- Rachel Feldman
- & Jennifer Shaffer
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Research Highlight |
A CRISPR approach to elucidate the role of enhancers during development and disease
- Alexandra Le Bras
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Comment |
The Dwarf Cuttlefish: a story of trials, exploration, and scientific frontiers
Far from the Indopacific, aquatics manager Josh Barber and veterinarian Rebecca Ober walk through the recently established dwarf cuttlefish program at Columbia University and share their lessons learned for others interested in these intriguing animals.
- Joshua Barber
- & Rebecca A. Ober
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Comment |
Know Your Model: A knockout does not always make a null
Creating a null mutation of a gene is a powerful way to examine gene function, but knocking out part of a gene does not always result in a null allele.
- Susan M. Bello
- , Michelle N. Perry
- & Cynthia L. Smith
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Protocol |
In vivo labeling of epithelial cell–associated antigen passages in the murine intestine
Goblet cell–associated antigen passages can deliver luminal substances to antigen-presenting cells to induce antigen-specific T cell responses. This protocol describes how to identify and quantify intestinal epithelial cells that have the capacity to take up luminal substances, by intraluminal injection of fluorescent dextran, tissue sectioning for slide preparation and imaging with fluorescence microscopy.
- Kathryn A. Knoop
- , Devesha H. Kulkarni
- , Keely G. McDonald
- , Jenny K. Gustafsson
- , Jazmyne E. Davis
- , Alexandria N. Floyd
- & Rodney D. Newberry
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Protocol Review |
On the reproducibility of methods or findings
- Shan Yan
- , Chandra Williams
- & Yvette Huet
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Technology Feature |
The quest for an animal model of coral health and disease
Could a ‘lab rat’ for the coral field help researchers conserve these threatened animals in the wild?
- Ellen P. Neff
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In This Issue |
In this issue
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Research Highlight |
A new chimeric model to study human brain development and disease
- Alexandra Le Bras
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Comment |
Confessions of a professional Worm Wrangler and Mouse Herder: the benefits of a hybrid career
A ‘day in the life’ of Dr. Jeanna Wheeler, a research scientist at the Seattle Institute for Biomedical & Clinical Research in Seattle, Washington. She works in the lab of Dr. Brian Kraemer, studying models of neurodegenerative diseases in worms and mice. Her most recent work can be found at
https://doi.org/10.1126/scitranslmed.aao6545 - Jeanna M. Wheeler
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News & Views |
Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains
Microglia play important but incompletely understood roles in the pathogenesis of neurological disease. New chimeric models using transplanted human stem cell-derived microglia-like cells hold great promise to better model the unique function of human microglia in brain disease.
- Fadi Jacob
- & Mariko L. Bennett
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News Feature |
2019 in animal genomes
Animal genomes are being sequenced left and right—we took a look back at those published in papers last year.
- Ellen P. Neff
