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Volume 53 Issue 4, April 2024

In vivo modeling of postpartum hemorrhage

Severe bleeding after childbirth – postpartum haemorrhage (PPH) – is a leading cause of maternal mortality worldwide. Several animal models have been developed for testing novel therapeutic materials; however, these animals differ considerably from the anatomy and physiology of a postpartum woman. In a new Review, Hargett, Leslie et al. critically evaluate available animal models of PPH and propose additional methods for modeling PPH in vivo.

See Gaharwar et al.

Cover image: Debbie Maizels. Cover design: Debbie Maizels.

Volume 53 Issue 4

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Protocol Review

  • A clear organizational reporting structure within the Animal Care and Use Program and a collegial working relationship between the Institutional Official, Attending Veterinarian and Institutional Animal Care and Use Committee are essential to maintain the highest standards of animal wellbeing and research quality. We invited experts from The Feinstein Institutes for Medical Research (Michelle Aparicio) and Rice University (Sarah Viranda and Elysse Ann Orchard), along with USDA and OLAW representatives (Louis DiVincenti and Axel Wolff), to respond to a challenging situation at Great Eastern University.

    • Lauren Danridge
    • Bill Greer
    • Axel Wolff
    Protocol Review

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News & Views

  • No, we are not talking about a new dish for dinner, but a study representing an emerging research field. Psilocybin research is gaining momentum, and zebrafish behavioral neuroscience research has been exponentially expanding. At the intersection of these two research fields is a recent paper that utilized high-tech video-tracking to detect behavioral changes induced by this psychoactive drug in larval zebrafish.

    • Robert Gerlai
    News & Views
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Review Articles

  • This Review provides a comprehensive overview of currently available animal models of postpartum hemorrhage, comparing their anatomy and physiology and highlighting their advantages and limitations to support therapeutic development for this condition.

    • Sarah E. Hargett
    • Elaine F. Leslie
    • Akhilesh K. Gaharwar
    Review Article
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