Metabolism in 3D

Metabolism is moving beyond flat biochemical charts into three dimensions, where dynamics in time and space lead to distinct biological outcomes and manipulation of metabolic pathways have the potential to address medical and societal needs. In this focus issue, we feature a collection of commentary and review articles that outline some of the ideas, advances and goals that are laying the foundations for the next era of metabolism research.



Metabolism in 3D

Beyond blueprints p495


Renewed interest in the biological significance and applied outcomes of metabolism is moving the field from static biochemical charts to multidimensional networks.



Metabolism in 3D

Teaching the design principles of metabolism pp497 - 501

Joshua D Rabinowitz & Livia Vastag


Learning metabolism inevitably involves memorizing pathways. The teacher's challenge is to motivate memorization and to help students progress beyond it. To this end, students should be taught a few fundamental chemical reaction mechanisms and how these are repeatedly used to achieve pathway goals. Pathway knowledge should then be reinforced through quantitative problems that emphasize the relevance of metabolism to bioengineering and medicine.



Metabolism in 3D

Rethinking glycolysis: on the biochemical logic of metabolic pathways pp509 - 517

Arren Bar-Even, Avi Flamholz, Elad Noor & Ron Milo


Metabolism in 3D

Engineering synthetic recursive pathways to generate non-natural small molecules pp518 - 526

Elizabeth A Felnagle, Asha Chaubey, Elizabeth L Noey, Kendall N Houk & James C Liao


Metabolism in 3D

Natural strategies for the spatial optimization of metabolism in synthetic biology pp527 - 535

Christina M Agapakis, Patrick M Boyle & Pamela A Silver


Metabolism in 3D

Systems metabolic engineering of microorganisms for natural and nonnatural chemicals pp536 - 546

Jeong Wook Lee, Dokyun Na, Jong Myoung Park, Joungmin Lee, Sol Choi & Sang Yup Lee


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