Colourful soap bubbles of different shapes

A medley of vesicles

Inspired by the Review by Alissa Weaver and colleagues on Context-specific regulation of extracellular vesicle biogenesis and cargo selection.

Featured

  • Membraneless organelles (MLOs) contribute to intracellular compartmentalization and to various cellular processes. This Review provides a guide to MLOs involved in gene regulation in eukaryotes, discussing their assembly, structure, roles in transcription, RNA processing and translation — particularly in stress conditions — and their disease relevance.

    • Tetsuro Hirose
    • Kensuke Ninomiya
    • Tomohiro Yamazaki
    Review Article

  • Selective autophagy engages several cargo receptors that target specific, potentially toxic, content (damaged organelles, protein aggregates, pathogens) for lysosomal degradation. Understanding of the mechanisms governing this process in mammals has expanded in recent years, opening the prospects for enhancing selective autophagy to boost cellular quality control capabilities.

    • Jose Norberto S. Vargas
    • Maho Hamasaki
    • Tamotsu Yoshimori
    Review Article

  • Reactive oxygen species (ROS) signalling is crucial in plant responses to abiotic and biotic stresses. This Review discusses our current understanding of ROS regulation and sensing in plants, key regulatory hubs that connect ROS signalling with other stress-response pathways and how ROS signalling could be harnessed to increase plant resilience to environmental stress.

    • Ron Mittler
    • Sara I. Zandalinas
    • Frank Van Breusegem
    Review Article

  • Extracellular vesicles (EVs) mediate cell–cell communication in physiology and pathology but many questions remain about the mechanisms governing their delivery to recipient cells. This Expert Recommendation article highlights areas of progress and challenges in establishing the importance of EV-mediated communication in vivo.

    • Guillaume van Niel
    • David R. F. Carter
    • Pieter Vader
    Expert Recommendation

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    Share your Tools of the Trade

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  • Colorful vesicles floating around

    Check out this new Collection from Nature Portfolio journals devoted to biology, function and clinical translation of extracellular vesicles, as well as associated technical developments that facilitate studies in this area.

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Latest Reviews & Analysis

    • Nucleobase modifications are prevalent in eukaryotic mRNA and are broadly required for post-transcriptional gene regulation. The most studied mRNA modification is N6-methyladenosine (m6A), yet various other modifications are now being identified and studied. This Review discusses the emerging mechanisms and roles of these non-m6A modifications.

      • Hanxiao Sun
      • Kai Li
      • Chengqi Yi
      Review Article

    • Single-cell multi-omics methods are essential for characterizing cell states and types. The past decade has ushered in improvements in spatial resolution and computational data integration and in new omics modalities. Consequently, single-cell multi-omics have advanced fundamental and translational research, including, for example, in production of cell atlases and in tumour immunology therapeutics.

      • Alev Baysoy
      • Zhiliang Bai
      • Rong Fan
      Review Article

    • Actin is most frequently associated with cell migration and shape control. However, actin has a multitude of other cellular roles, including regulating the function and dynamics of organelles. This Review discusses a plethora of actin functions in mitochondrial biology.

      • Tak Shun Fung
      • Rajarshi Chakrabarti
      • Henry N. Higgs
      Review Article

    • Structural maintenance of chromosomes (SMC) complexes, which connect regulatory DNA elements, form chromatin loops and hold together sister chromatids, are required for accurate chromosome segregation and of control transcription, replication and DNA repair. It has recently become clear that SMC complexes also control nuclear organization by counteracting clustering between similar chromatin regions.

      • Claire Hoencamp
      • Benjamin D. Rowland
      Review Article

    • Skeletal muscles show high metabolic flexibility and functional plasticity in their response to different exercise modalities. Recent findings have advanced our understanding of signalling, transcriptional and epigenetic mechanisms that regulate muscle adaptation to exercise and their impact on muscle physiology.

      • Jonathon A. B. Smith
      • Kevin A. Murach
      • Juleen R. Zierath
      Review Article

News & Comment

  • During cellular stresses, the mRNA internal 7-methylguanosine (m7G) modification is bound by QKI-7, which regulates the stability and/or translation of the mRNAs by sequestering them in stress granules.

    • Eytan Zlotorynski
    Research Highlight

  • In this Tools of the Trade article, Edoardo José Longarini and Helen Dauben (from the Matić lab) describe the development and applications of mono-ADP-ribosylation antibodies and peptides.

    • Edoardo José Longarini
    • Helen Dauben
    Tools of the Trade

  • Rogers et al. provide evidence that hypoxia is beneficial in mammalian ageing, extending the lifespan of prematurely ageing mice.

    • Paulina Strzyz
    Research Highlight

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The sea with lipid rafts

Lipids and membranes

This article series brings together Reviews that focus on key advances in understanding membrane biology as well as the regulation and functions of their lipid components, including their roles as bioactive molecules and their interplay with metabolism.
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