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    Phase separation (PS) refers to the de-mixing process of a homogenous phase to form dense and dilute phases, which is explored in this collection of recent articles from Nature Chemical Biology that aim to reveal the molecular and chemical principles underlying phase-separated condensate formation, promote the development of new tools for the study of PS biology, and broaden the application of these tools in chemical biology and biomedicine.

    Image: Xuefeng Sun (photography), Hao He (image editing), Guangya Zhu (design)

  • Collection |

    The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry.

    Image: Springer Nature/The Nobel Foundation/Imagesource

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    This themed issue presents a collection of Reviews, Perspectives and Articles that aims to showcase how chemical tools have strengthened the existing interplay between physiology, chemical biology and biochemistry – to reveal new insights into cellular regulation.

    Image: filo / DigitalVision Vectors / Getty Images

  • Special |

    Genome Engineering has great potential to change how we model, understand, and treat diseases.

    Image: XVIVO

  • Collection |

    The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch."

    Image: Springer Nature/The Nobel Foundation/Imagesource

  • Collection |

    Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.

  • Collection |

    Genetically encoded (protein-based) fluorescent biosensors have been developed to enable imaging and monitoring of a variety of metabolites and cellular events, as highlighted in this collection of recent papers from Nature Portfolio.

    Image: Michel Herde

  • Focus |

    This themed issue combines Reviews and Perspectives as well as original research that highlight the evolution of the approaches and conceptual advances in the study of cellular membranes and their component parts, lipids and proteins.

  • Collection |

    The 2020 Nobel Prize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer Doudna for their pioneering work in gene-editing.

    Image: Springer Nature/The Nobel Foundation/Imagesource

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    The June 2020 issue of Nature Chemical Biology marks 15 years of publication for the chemical biology community.

    Image: John Tolliday / Alamy Stock Photo; Cover Design: Erin Dewalt

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    In our March 2018 issue, Nature Chemical Biology presents a collection that explores chemical tailoring of biomolecules within cells and highlights how chemical biology expands our mechanistic understanding of these modified biomolecules and provides tools to illuminate their biological functions.

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    The development of model organisms such as zebrafish and worms progresses from a single cell to tissues and organs. In this issue, a collection of articles highlights advances and opportunities at the intersection of developmental and chemical biology.

    Image: Credit: Erin Dewalt / Springer Nature