In open nonequilibrium systems, interactions that break the action-reaction symmetry are ubiquitous in nature. While such nonreciprocal interactions have been implemented for quantum systems, they typically require fine microscopic control of dissipation. Here, Hanai, Ootsuki and Tazai propose a dissipation engineering scheme that induces nonreciprocal interactions in solid state materials, giving rise to a persistent many-body chase-and-runaway dynamics of magnetism in layered ferromagnets.

AI scientists powered by large language models and AI agents present both opportunities and risks in automatic scientific discovery. Here, the authors examine the vulnerabilities of AI scientists, propose a risk taxonomy based on user intent and impact domains, and develop a triadic safeguarding framework emphasizing human regulation, agent alignment, and environmental feedback understanding.

Radical methylation ranks among the most important yet challenging transformations in chemistry and biology, which often involves small and unstable radical intermediates, and results in low reactivity and poor selectivity. Herein, the authors report a bioinspired transfer methylation protocol for the direct and selective C(sp²)-H methylation of heteroarenes.

Asteroid 1998 KY26 is the target of Hayabusa2 extended space mission. Here, authors show that it is smaller and rotates faster than known.

The authors propose and demonstrate the concept of photonic-electronic arbitrary-waveform generation, overcoming the bandwidth limitations of all-electronic systems. The idea is to exploit quadrature multiplexing of optical waveforms and opto-electronic conversion by phase-stabilized coherent detection.

A better-ventilated North Pacific could have reduced the carbon of water upwelled in the Southern Ocean, reducing outgassing and revealing a remote influence on Southern Ocean biogeochemistry in glacial times.

Meteorite impacts can create long-lived hydrothermal systems that may spark onset of microbial life. At Finland’s Lappajärvi crater, minerals in fractures contain biosignatures of microbial life related to the hydrothermal circulation, offering clues to deep microbial colonization of Earth and beyond.

Millions of people each year are forcibly displaced due to floods. Mester et al. show that measures of human development and rural areas are more important than GDP per capita in explaining the varying vulnerability to such displacement.

A year-long experiment in a wet tropical forest found that 4 ^oC of warming boosted soil CO₂ emissions by 42-204%. These high rates suggest tropical soils may release more carbon under future warming than climate models predict.

The authors show that prenatal propylparaben exposure causes transgenerational inheritance of diminished ovarian reserve via Rhobtb1 hypomethylation, with similar patterns in patient samples. Methyl-donor diet counteracts this, suggesting therapeutic potential.

Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3^WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

Here, the authors develop a microneedle system that converts 5-ALA photodynamic byproducts into therapeutic fuel, enhancing ferroptosis and improving hypertrophic scar treatment.

How do distinct types of protrusive cells arise on a single organ? Here the authors show different mechanisms specifying conical cells, short trichomes, and long hairs on Nigella petals and the contribution of gene co-option to the evolution of trichomes and hairs.

Debio 1453, a FabI inhibitor, shows potent activity against antibiotic-resistant Neisseria gonorrhoeae, rapidly killing bacteria in vitro and clearing infection in mice, supporting its potential for treating drug-resistant gonorrhoea.

The MRN complex plays a key role in detecting, signalling, and processing DNA double-strand breaks. This study reports the cryo-EM structures of human MRN bound to DNA, alone and with telomeric protection factor TRF2, revealing MRN’s structural transitions and regulatory mechanisms.

Here the authors identify RNA G-quadruplexes as temperature-sensitive regulators of alternative splicing and gene expression, opening potential therapeutic avenues such as neuroprotection with potassium channel blockers.

CRISPR-based diagnostics are often limited by complex workflows and poor validation. Here the authors develop and validate a one-pot asymmetric CRISPR assay, which permits rapid and sensitive diagnosis of tuberculosis in a format which is suitable for resource-limited settings.

Menstrual disturbance has been reported as a symptom of post-acute COVID-19 while other long COVID symptoms may vary across the menstrual cycle. Here, the authors investigate this possible bidirectional relationship in a series of observational studies of women in the UK.

Human transplantation with allogeneic donor organs results in non-matching of MHC and differential presentation of T cell antigens. Here the authors show that in a lung transplanted SARS-CoV-2 infected patient T cell responses generated from the host may not be able to recognise infected cells within the graft and this may contribute to virus persistence.

Surprisingly consistent replication failure of gray matter correlates of childhood maltreatment raises questions about publication bias in prior literature and about prevailing models linking maltreatment to brain structure in adult populations.

Millions of people each year are forcibly displaced due to floods. Mester et al. show that measures of human development and rural areas are more important than GDP per capita in explaining the varying vulnerability to such displacement.

This study of 89 multinational firms finds no significant link between voluntarily offsetting emissions and decarbonization speed. Firms spend little funds on carbon credits, and emission offsetting is not a central part of their climate strategies.

Industrial decarbonization poses both risks and benefits for communities. We show how community-based research can move pervasive yet nebulous calls for community engagement to processes that emphasize just and equitable governance.

Existing ambition assessments of national climate pledges are biased, incompatible with international law and reward high emitters. Immediately accounting for the equity obligations of the Paris Agreement implies important financial support now.

Understanding global methane trends remains limited, especially from a consumption view. This study shows rising emissions, limited decoupling, and shifting trade patterns involving more emerging and developing economies.