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Nature Communications is an open access journal that publishes high-quality research in biology, physics, chemistry, Earth sciences, and all related areas.

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  • Article | | open

    Several metabolic factors affect cellular glucose metabolism as well as the innate inflammatory response. Here, the authors show that glucose metabolism regulates pro-inflammatory responses through effects on the cytosolic NADH:NAD+ ratio and the NAD(H)-sensitive transcription co-repressor CtBP.

    • Yiguo Shen
    • , David Kapfhamer
    • , Angela M. Minnella
    • , Ji-Eun Kim
    • , Seok Joon Won
    • , Yanting Chen
    • , Yong Huang
    • , Ley Hian Low
    • , Stephen M. Massa
    •  & Raymond A. Swanson
  • Article | | open

    In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

    • Julia F. Hopkins
    • , Veronica Y. Sabelnykova
    • , Joachim Weischenfeldt
    • , Ronald Simon
    • , Jennifer A. Aguiar
    • , Rached Alkallas
    • , Lawrence E. Heisler
    • , Junyan Zhang
    • , John D. Watson
    • , Melvin L. K. Chua
    • , Michael Fraser
    • , Francesco Favero
    • , Chris Lawerenz
    • , Christoph Plass
    • , Guido Sauter
    • , John D. McPherson
    • , Theodorus Kwast
    • , Jan Korbel
    • , Thorsten Schlomm
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Article | | open

    Spintronic devices with full electrical control rely on electrical generation and detection of spin currents in the absence of magnetic materials. Here, the authors use Pt, a non-magnetic metal, to generate and detect pure spin currents in a few-layer graphene channel, achieving a remarkable spin-to-charge voltage signal at room temperature.

    • Wenjing Yan
    • , Edurne Sagasta
    • , Mário Ribeiro
    • , Yasuhiro Niimi
    • , Luis E. Hueso
    •  & Fèlix Casanova
  • Article | | open

    O-linked β-N-acetyl glucosamine (O-GlcNAc) is an important protein modification that is hydrolyzed by O-GlcNAcase (OGA). Here the authors give insights into OGA substrate recognition by presenting four human OGA structures complexed with glycopeptide substrates containing a single O-GlcNAc modification on either a serine or threonine.

    • Baobin Li
    • , Hao Li
    • , Chia-Wei Hu
    •  & Jiaoyang Jiang
  • Article | | open

    The development of future computation devices will be aided by a better understanding of the physics underlying material behaviors. Using thermoreflectance and spatially resolved X-ray microscopy, Kumar et al. elucidate the origin of two types of negative differential resistance in NbO2 memristors.

    • Suhas Kumar
    • , Ziwen Wang
    • , Noraica Davila
    • , Niru Kumari
    • , Kate J. Norris
    • , Xiaopeng Huang
    • , John Paul Strachan
    • , David Vine
    • , A.L. David Kilcoyne
    • , Yoshio Nishi
    •  & R. Stanley Williams
  • Article | | open

    Avenaol is a potent germination stimulant that can be extracted from black oat. Here, the authors report the total synthesis of avenaol by developing a strategy to access all-cis-substituted cyclopropanes.

    • Motohiro Yasui
    • , Rina Ota
    • , Chihiro Tsukano
    •  & Yoshiji Takemoto

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