Advanced fabrication techniques enable a wide range of quantum devices, such as the realization of a topological qubit. Here, the authors introduce an on-chip fabrication technique based on shadow walls to implement topological qubits in an InSb nanowire without fabrication steps such as lithography and etching.

C-Glycosyl peptides/proteins are metabolically stable mimics of the native glycopeptides/proteins of great therapeutic potential, but their chemical synthesis is challenging. Here, the authors report a protocol for the synthesis of vinyl C-glycosyl amino acids and peptides, via a Ni-catalyzed reductive hydroglycosylation reaction of alkyne derivatives of amino acids and peptides with glycosyl bromides.

Widely existing self-organised complex structures in nature exhibit a high level of sophistication, yet can one program the self-assembly process to achieve similar result in the lab remains unanswered. Here, Serafin et al. present a non-Euclidean self-assembly theory for polyhedral nanoparticles that offers insight on how to manipulate the process for realising new material capabilities.

Preserving the large power factor of carbon nanotubes is challenging, due to poor sample morphology and a lack of proper Fermi energy tuning. Here, the authors achieve a value of power factor of 14 ± 5 mW m⁻¹ K⁻² originating from the preserved conductivity and the ability to tune Fermi energy.

Current designs of thermal switches are limited by a lack of continuous tunability, low switching ratio, low speed, and not being scalable. Here the authors report a continuously tunable, wide-range, fast, and cost effective thermal switching approach that is demonstrated using compressible graphene composite foams.

Episodic magmatism of the early Andes is the result of a complex interplay between mantle, crust, slab and sediment contributions that can be traced using zircon chemistry. An external (tectonic) model is argued for the episodic plutonism in this extensional continental arc.

How climate change influences the lifecycle of stratospheric volcanic aerosols and the associated radiative forcing is unknown. Here, the authors present model experiments suggesting that climate change amplifies the forcing of large-magnitude tropical eruptions but reduces the forcing of moderate-magnitude tropical eruptions.

The fraction of leaf nitrogen allocated to RuBisCO indicates differing nitrogen use strategies of plants and varies considerably. Here the authors show that this variation is largely driven by leaf thickness and phosphorus content with light intensity, atmospheric dryness and soil pH also having considerable influence.

Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell responses to prevent gut inflammation.

The link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice.

Age-related clonal hematopoiesis is associated with risk for diseases like acute myeloid leukemia (AML), yet it is unclear why some individuals do not progress despite having AML driver mutations. Here, the authors use deep learning and population genetics models to investigate how the interplay of positive and negative selection influences AML progression.

Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.

In the cerebral cortex, information is processed by multiple hierarchically organized areas, reciprocally connected via feedforward and feedback circuits. Here the authors show that in primate visual cortex, feedforward projection neurons receive monosynaptic feedback contacts selectively from the area to which they project.

Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.

Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone strength in mice and fracture risk in humans.

Hexanucleotide repeat expansion in the intron 1 of the C9ORF72 gene can cause amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). Here the authors use single molecule imaging to show nuclear export and translation of circular repeat-containing C9ORF72 intronic RNA.

Performing multiple histological stains on a biopsy can be costly and time consuming. Here the authors present a method for the digital transformation of H&E stained tissue into special stains (e.g., PAS, Masson’s Trichrome and Jones silver stain), and demonstrate that it improves diagnoses over the use of H&E only.

Lipid accumulation in the liver leads to nonalcoholic fatty liver disease (NAFLD) that is a risk factor for developing hepatocellular carcinoma (HCC). Here, the authors show that activation of the translation initiation factor eIF6 promotes lipid accumulation in the liver and targeting eIF6 in murine models reduces NAFLD and associated HCC.

COVID-19 has decreased power sector emissions globally and in the United States. Here the authors assess whether such reductions would have occurred in the United States in the absence of the pandemic, as well as the potential impact of COVID-19 on coal-fired power plant retirements through 2022.

This paper quantifies global urban water scarcity in 2016 and 2050 and explores potential solutions. One third to nearly half of the global urban population is projected to face water scarcity problems.

China has introduced a payment-for-ecosytsem-services program called GECP which is focused on pastoral communities in grassland areas. Here, the authors combine remote sensing and household survey data to find small improvement in grassland quality and a significant positive effects on the income of herders.

Urban income segregation is often discussed in terms of where people live. Here, the authors show that the way people experience income segregation is also associated with their mobility patterns and the places they visit.

Understanding motivations underlying acts of hatred are essential for developing strategies to prevent such acts against marginalized groups. Here the authors show that group-based moral values are associated with tendency to justify extreme behavioural expressions of prejudice.