Researchers present the evidence and mechanism of distinct phase transformation pathways in MAX phases under ion irradiation, providing a new theory and predictive method for phase behavior based on composition, advancing understanding of materials in extreme conditions.

The authors report a wet-chemical selenization-based anisotropy optimization to control the orientation of the Ag₂Se thin film, achieving a power factor of 30.8 μW cm⁻¹ K⁻² in the thin film and a normalized power density of 1.8 μW cm⁻² K⁻² in the device.

Methods for creating large DNA assemblies with low cost and enhanced structural control are of interest. Here, the authors report moDON (modular DNA origami nanostructure) that combines two approaches to modularity resulting in tens of thousands of different monomers and superstructures, constructed at biological time scales and minimal cost.

Organic films containing unsaturated lipids are widespread, but their oxidation pathways remain poorly explored under indoor environmental conditions. Here, the authors demonstrate that UVA radiation and radical exposure drive rapid autoxidation of thin films of methyl linolenate and canola oil, primarily producing organic hydroperoxides. This autoxidation chemistry occurs under dark indoor conditions.

A growing portfolio of Ru-based single-crystal optical actuators is forging a new class of photonic materials that hold prospects for quantum technologies but complete photoconversion into each SO₂-isomeric state is rarely achieved. Here, the authors report the photoisomerization of trans-[Ru(SO₂)(NH₃)₄(4-bromopyridine)]tosylate₂.

Organic films containing unsaturated lipids are widespread, but their oxidation pathways remain poorly explored under indoor environmental conditions. Here, the authors demonstrate that UVA radiation and radical exposure drive rapid autoxidation of thin films of methyl linolenate and canola oil, primarily producing organic hydroperoxides. This autoxidation chemistry occurs under dark indoor conditions.

Companies benefit from some discretion on how to disclose their emissions, leading to potential underestimations of GHG footprints. Focusing on direct methane emissions, this paper quantifies a sizeable emission gap and associated transition risks.

During the long-term unrest of the Campi Flegrei caldera, burst-like seismic swarms are observed and associated with an increase in hydrothermal activity and an anomaly in the ground deformation pattern recorded since 2021.

Import restrictions on deforestation-linked commodities, like oil crops, could cut land-use emissions but risk emissions leakage globally and economic losses for producers. Direct forest protection may be more effective than import restrictions.

Here authors investigate the effects of different metals incorporated in the structures and possible additional phases have on the CO₂ uptake of pyrene-based MOFs. Results show that when additional phases are present, the pore volume is reduced and CO₂ binding sites in the structure are different, leading to different adsorption properties.

Functional tissue units (FTUs) form the basic building blocks of organs and are important for understanding and modeling their healthy physiological function and disease states. Here, the authors present a catalog of 22 anatomically based FTUs from 10 healthy human organs as part of an ongoing international effort to construct a Human Reference Atlas of all cells in the human body.

Spatial gene expression provides insights into disease mechanisms. Here, authors benchmark eleven methods predicting spatial gene expression from histology images across five datasets and external validation, providing insights into clinical utility, challenges, and future directions.

Current classification systems of pituitary neuroendocrine tumors (PitNETs) rely on histological hormone staining and transcription factors. Here, the authors analyze alternative splicing at bulk and single-cell resolution in PitNETs, revealing additional subtypes associated with worse clinical outcomes and splicing abnormalities.

Traditional protein engineering methods are often slow and labor-intensive. Here, authors develop an automatic protein evolution platform enabled by a protein language model. Using this platform, they significantly improved the activity of a tRNA synthetase within ten days.

Translocation into neurons is crucial for BoNT/A1 action. Here, the authors show by single-particle cryo-EM that BoNT/A1 bound to its receptor SV2B switches its conformation from an open, translocation-incompatible to a semi-closed, translocation-competent state at acidic pH.

Disturbed lipid metabolism is a feature of diabetic kidney disease (DKD). Here the authors report that ceramide synthase 6 (CerS6) in podocytes contributes to the pathogenesis of diabetic kidney disease (DKD) in male mice by inducing mitochondrial DNA leakage, activating the cGAS-STING pathway and promoting inflammation.

Metabolic dysregulation in the development of clear cell renal cell carcinoma (ccRCC) remains to be understood. Here the authors identify that a carnitine synthesis enzyme BBOX1, which inhibits TBK1-mTORC1 signaling and glycolysis, is often lost in ccRCC.

A multi-ancestry genome-wide association study meta-analysis of chronic back pain in 553,601 participants from the Million Veteran Program revealed 67 new genome-wide significant loci with gene enrichment in brain and pituitary tissues.

Import restrictions on deforestation-linked commodities, like oil crops, could cut land-use emissions but risk emissions leakage globally and economic losses for producers. Direct forest protection may be more effective than import restrictions.

Rossetti and coauthors explore how human cooperation dynamics shift when players engage in multiple economic games at the same time, rather than treating each game as isolated. The authors find that cognitive constraints, strategic motives, and spillover effects can reduce cooperation in such scenarios, challenging traditional models of direct reciprocity.

Companies benefit from some discretion on how to disclose their emissions, leading to potential underestimations of GHG footprints. Focusing on direct methane emissions, this paper quantifies a sizeable emission gap and associated transition risks.

This study explores single-cell protein (SCP) production via renewable electricity, outlining cost trajectories and scalability. SCP could become a sustainable and affordable protein supply, decoupling food systems from land and water constraints.

Here the authors show that an emotion regulation intervention for reducing negative intergroup emotions in conflicts can decrease negative emotions not only in treated participants but also in nontreated participants through emotion regulation contagion.