This study presents an ultracompact eye camera using a novel low aspect-ratio metalens design. Achieving a 120° field of view, the system enables high-performance gaze tracking and iris recognition, ideal for future augmented reality glasses.

The Soai reaction occupies a singular role in organic chemistry and chemical kinetics due to its autocatalytic and self-amplification behavior, which has spurred intense mechanistic investigation and debate. Here, the authors use in situ high-resolution mass spectrometry and accompanying techniques to identify reaction intermediates and bring about more granular detail of the reaction.

Efficient oxygen activation limits oxidative catalysis. Here, incorporating single-atom Zr into CeO₂-supported Pt catalysts creates Zr₁–O–Pt₁ structures, significantly enhancing catalytic performance via boosted surface and chemisorbed oxygen activation.

In this article, authors explore the potential of photoelectrochemical systems for chemical separations, showing that low solar efficiency materials can be viable and cost-effective for water treatment and resource recovery, offering a potentially broader design space than traditional photoelectrochemistry applications.

The authors find that electric-field gating-controlled lithium intercalation can switch FeSe reversibly between a nonmagnetic superconducting state and a high-temperature superconducting ferromagnetic state. Further, scanning-SQUID magnetometry reveals that the ferromagnetic domains survive deep in the Meissner state and coexist spatially.

Unprecedented groundwater recovery ( ~ 0.7 m/yr) driven by water diversions, strict pumping regulations, and a wet climate occurred in the North China Plain after decades of depletion, showing large-scale recovery is possible under human intervention.

Silver nanoparticles are used in a wide range of applications but have potential toxicity issues. Here, the authors report on a gut bacterium which can protect nematodes from reproductive harm caused by silver nanoparticles via the production of protective metabolites showing a strategy for mitigating nanoparticle toxicity.

The combination of isotopic tracers with root phenotyping reveals specific patterns in photosynthate allocation. These patterns are reflected in rhizodeposition and result in spatially distinct microbiomes within the plant root system.

Metal-driven anaerobic oxidation of methane and methanogenesis, mediated by a diverse microbial community, drove iron-mineral transformation and may have aided ice sheet melting, according to analysis of Sturtian iron formations from South China

This study shows that changes in ocean gateways near the end of the Mesozoic (~66 Ma) altered global ocean salinity and circulation, reshaping climate patterns through combined reconfigurations in the Arctic and Central American regions.

Poly(A)-Binding Protein Cytoplasmic 1 (PABPC1) is a crucial component of stress granules. Here, the authors show that PABPC1 undergoes SUMOylation in response to cellular stress, enhancing the stability of mitophagy-related gene transcripts to promote cancer cell survival.

Human papillomavirus (HPV) DNA testing is the preferred method for cervical cancer screening, but existing tests are inaccessible for resource-limited settings. Here, authors develop a low-cost, simple HPV DNA assay suitable for bedside testing and demonstrate strong performance in Mozambique.

Epimutations mediated by RNA interference can confer antifungal drug resistance and affect virulence in fungi. Here, the authors show that these epigenetic modifications can be transmitted across generations following sexual reproduction in a pathogenic fungus.

SCRaMbLE can optimise traits via gene rearrangement but is limited by screening. Here the authors use FACS and long-read sequencing with iterative SCRaMbLE to map genotype diversity and gene arrangements, identifying solutions for improving genome design.

This trial evaluated the immunogenicity and safety profiles of a bivalent aerosolized adenovirus-vectored COVID-19 vaccine and an intramuscular bivalent mRNA booster. The mRNA booster induced higher neutralizing antibody levels and a distinct memory B cell response, yet was associated with a higher incidence of adverse reactions.

Multi-omics can be used to characterise tumour and immune cell populations. Here the authors use multi-omics to characterise CLL blood and tissue samples and use prediction models for CLL TCR specificity and implicate interactions between galectin-9 and TIM3 as involved in CLL immune escape and propose galectin-9 as a possible immunotherapy target.

In this phase 2 trial, YKYY017, a SARS-CoV-2 membrane fusion inhibitor, was tested against mild to moderate COVID-19. Inhaled YKYY017 at 20 mg produced a numerically higher viral load reduction compared with placebo on Day 4, suggesting potential antiviral activity. Both inhaled 10 mg and 20 mg YKYY017 were well-tolerated and had acceptable safety profiles.

Bruton tyrosine kinase (BTK) inhibitors can interrupt the crosstalk between follicular lymphoma FL cells and macrophages thereby inducing downregulation of pro-survival pathways in FL cells. Here this group reports a phase 2 single-arm trial evaluating the regimen of acalabrutinib with lenalidomide plus rituximab on twenty four patients with previously untreated FL.

The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, along with 38 candidate genes, providing evidence for shared genetics with other developmental disorders.

Complement proteome engagement is strongly linked to kidney outcomes in diabetes. This translational study leveraged five cohorts of over 4,500 person-years and high-throughput proteomics to enable potential biomarker-guided drug development.

A four-dimensional mine-level model for jointly produced metals captures interdependencies among copper, cobalt, and nickel markets. It challenges assumptions that by-products like cobalt cannot affect host metal markets, providing new insights into by-product economics and their implications for supply chain resilience.

Here, the authors discuss principles of experimental design that are relevant for all biology research, along with special considerations for projects using -omics approaches, highlighting common experimental design pitfalls and how to avoid them.

Repeated exposure to misinformation reduces moral condemnation of sharing those falsehoods online. Here, the authors show that this finding replicates and generalizes to new settings and headlines.

This study shows that while deep building renovation could reduce carbon emissions, it increases material use and costs. Circular strategies help reduce primary material demand, but incentives are needed to make renovation economically viable.

Head and neck cancer patients could greatly benefit from personalised treatment, but a lack of large public datasets hampers this potential. Here, the authors present HANCOCK, a multimodal dataset that integrates demographical, clinical, and histopathological data for 763 head and neck cancer patients that empowers machine learning models for clinical outcome prediction.