Nanoresonator is proven to be an excellent platform for molecular detection, yet a set of them is necessary to identify a molecule fingerprint. Here, the authors utilise low quality resonators with large radiative losses, despite its lower quality factor, to identify molecular absorption spectrum between 5 and 10 μm.

Axially chiral N-arylpyrrole motifs are privileged scaffolds in numerous biologically active compounds but asymmetric synthesis of N-arylpyrroles is challenging. Here, the authors develop a diastereo- and atroposelective synthesis of N-arylpyrroles enabled by light-induced phosphoric acid catalysis.

Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals but the direct single-step synthesis with broad structural diversity remains challenging. Herein, the authors report a modular assembly of tetrahydrocarboline type of indole alkaloids from simple building blocks in a single step while showing broad compatibility with medicinally relevant functionality

Vibrational polaritons steer chemical reactions and control quantum states for information processing. Here the authors predict their formation during electronic photo-excitation, enabling a down-conversion of visible to infrared photons.

Manipulation of nano-sized extracellular vesicles are of significant interest for disease detection, monitoring, and therapeutics, yet it is still challenging to expedite the process. Here, the authors presented geometry-induced electrohydrodynamic tweezers, which enable fast parallel transport and trapping of single vesicle within seconds.

Sea level fall with the growth of the Antarctic Ice Sheet 34 million years ago, and the shift in nutrients and carbon from continental margins to the ocean, initially provided a negative feedback that slowed global cooling and ice sheet expansion.

Earthquakes often originate along faults in the presence of hot and pressurized water. Experiments conducted on simulated faults reveal that the physical state of water (liquid, vapor or supercritical) controls the frictional resistance of faults.

Potential lead contamination risk and environmental vulnerability risk impose a significant obstacle for the commercialization of perovskite solar cells. Here, the authors create a biomimetic cage traps to mitigate lead leakage and establish a sustainable closed-loop lead management process.

Southern Oman speleothem oxygen isotope and multi-proxy data reveal diverse changes in the Afro-Indian summer monsoon circulations and local hydroclimate conditions during the Holocene, confirming climate model simulations.

New and existing paleoclimatic records show the rain-belt range of the Intertropical Convergence Zone (ITCZ) in the Indo-Asian-Australian monsoon region contracted to the northern low latitudes during the early Heinrich Stadial 1

Aminoacyl-tRNA synthetases catalyze the ligation of amino acids to their cognate tRNAs. Here the authors report the cryo-EM structure of a human mitochondrial seryl-tRNA synthetase•mtRNA^Ser complex showing how strong mutation pressure on mtRNA genes drove a rewiring of intermolecular recognition rules.

The cellular responses below the lesion remain unclear after spinal cord injury (SCI). Here, authors show region-heterogeneous responses in the SCI monkey by single-cell transcriptomics analysis and uncover the mechanism of scaffold-based SCI repair.

Cholesterol synthesis is highly oxygen consuming but how it is regulated by oxygen levels has not been clear. Here, Dickson et al. identify a HIF-independent, oxygen-sensing pathway for controlling cholesterol synthesis in human cells involving hypoxic-mediated degradation of SREBP2.

The relative protection against Omicron SARS-CoV-2 infection conferred by vaccination and previous infection are not fully understood. Here, the authors use data from a prospective cohort study in the Netherlands and show that hybrid immunity (vaccination plus previous infection) conferred strongest protection.

Bone marrow adiposity is linked to disease, and it is unknown how it is modulated during space travel. Here, the authors show that astronauts returning from ISS missions had decreased marrow fat and increased hematopoiesis, suggesting that adipose reserves in the bone marrow might be used as an energy source to counteract anemia associated with space flight.

Ex vivo perfusion is a unique platform to study isolated human lungs. Here, authors show that a machine learning model, InsighTx, derived from data generated during ex vivo lung perfusion can accurately predict transplant outcomes and increase organ utilization rates.

Branched chain ketoacid dehydrogenase kinase (BDK) inhibits the activity of branched chain ketoacid dehydrogenase and branched chain amino acid degradation, implicated in several diseases. Here, the authors discover a BDK inhibitor and degrader that shows efficacy in rodent metabolism and heart failure models, as well as another class of BDK inhibitors that stabilizes BDK.

Long-term machine perfusion of human livers outside the body is an emerging field with tremendous potential for the assessment, recovery, and modification of organs prior to transplantation. Here, the authors report the long-term ex situ perfusion of human livers and demonstrate the ability to split and perfuse these organs using a standardised protocol.

Corporate procurement initiatives, such as RE100, can increase their impact on the energy transition by formulating ambitious interim targets and sourcing requirements, and by orchestrating corporate interests in countries with less ambitious renewable energy targets.

This work quantifies the climate benefits of efficiently utilizing concrete through improved material and structural design, and it shows that over 75% of CO2 emissions from global concrete production could be cut with already implementable measures

Measurement error in polygenic indices attenuates their power to predict complex traits. Here, the authors compare two approaches addressing this attenuation bias and provide guidance on which approach to apply in various scenarios.

The increase of intermittent energy sources and renewable energy penetration generally results in reduced overall inertia, making power systems susceptible to disturbances. Here, authors develop an AI-based method to estimate inertia in real-time and test its performance on a heterogeneous power network.

This study shows that 716 million of the world’s lowest income people live in areas with unsafe levels of air pollution, especially in Sub-Saharan Africa. With limited access to healthcare, they are especially vulnerable.