Stretchable polymer semiconductors with high mechanical and electrical properties are challenging to develop. Wu et al. show that reversible molecular ordering under strain important for performance optimization and relative stretchability can be used to compare the relative strain tolerance of materials.

The scalable production of polyimide aerogel fibers, promising intelligent thermal management fabrics, is limited by the slow gelation kinetics and the weak backbone. Here, the authors present a UV-enhanced dynamic gelation strategy for fast and scalable preparation of cross-linked polyimide aerogel fibers by wet spinning and cost-effective ambient pressure drying.

Neurostimulators are often bulky and uncomfortable. Researchers report a wireless, leadless, and battery-free ultrasound receiver that wraps around the target peripheral nerve and allows precise modulation of organ function, providing a framework for future bioelectronic medicines

Processing of conventional infrared-transparent materials limits their applicability. The authors demonstrate 3D printing of thiol-ene optical components with mid- and long-wave infrared transparency with applications such as reaction temperature monitoring.

Ceramics are very brittle and hard to be plastically deformed. Here, the authors report a unit-cell scale disturbance mechanism to improve the deformation ability of ceramics and ultimately achieve large mechanical property enhancement.

Forest restoration in LMICs can contribute to global C mitigation targets. Here, the authors assess the economic feasibility of forest restoration methods in Panama, i.e. natural regeneration, native species plantings, and enrichment planting, showing that not all methods are economically viable.

Aggressive or uniform actions on climate targets may exacerbate regional inequality and induce economic losses in China. The proposed collaborative strategy for carbon neutrality can avoid up to 1.54% of GDP losses while 90% of provinces would gain.

Ben-Yami et al. present methods to quantify uncertainties and address biases in indicators for detecting stability changes in key Earth system components. Data gap filling introduces biases, but the stability decline in the North Atlantic remains significant.

AI-driven daily 1-km gapless PM_2.5 data reveal the dynamics of unhealthy air around the world, stark disparities exist between nations and among neighbourhoods. Drastic air quality changes are associated with implementation and lifting of lockdown policies.

By building transcontinental power pools, Yang and colleagues find global electricity demand can be 100% met by renewables, at an affordable cost.

Energetic local frustration in proteins may have been positively selected by evolution when related to function such as ligand binding, allostery and other. Here the authors present a methodology to analyze local frustration patterns within protein families and superfamilies.

Renal cell carcinoma (RCC) subtypes are associated with different molecular alterations and clinical outcomes, but they need to be characterised in diverse cohorts. Here, the authors perform genomic, transcriptomic, and epigenomic profiling in a large cohort of Japanese RCC cases, and identify epi-subtypes associated with a particular immune environment.

Inferring lineage trees while incorporating gene expressions and lineage barcodes is a challenging task. Here, authors present LinRace, which infers improved cell lineage trees and ancestral cell states using the proposed asymmetric division model.

How aging affects the brain active milieu remains unknown. Here, the authors reveal atrophy and mitochondrial malfunction of astrocytes but not neurons in older human neocortex.

Nirmatrelvir/ritonavir can reduce COVID-19 severity when initiated within five days of symptom onset but the optimal timing within this window is unknown. Here, the authors emulate a randomised trial using electronic health records from Hong Kong and find evidence for a benefit of early treatment initiation.

Renal cell carcinoma (RCC) subtypes are associated with different molecular alterations and clinical outcomes, but they need to be characterised in diverse cohorts. Here, the authors perform genomic, transcriptomic, and epigenomic profiling in a large cohort of Japanese RCC cases, and identify epi-subtypes associated with a particular immune environment.

Hypertension is a major risk factor for cardiovascular disease prevalent in Africa. Here the authors report a genome-wide study providing insights into the genetics and physiology of blood pressure variation in African populations.

Critical illness leads to altered metabolic states and bioenergetic failure caused by impaired utilisation of glucose, fatty acids and amino acids. Here the authors show ketogenic diets may provide a safe and acceptable alternative metabolic fuel enabling energy production and maintaining tissue homeostasis.

Serotonin 5-HT_2A receptor signaling mechanisms associated with predicting psychedelic potential remain elusive. Using 5-HT_2A-selective β-arrestin-biased ligands, here the authors show that a threshold level of 5-HT_2A-Gq efficacy and not β-arrestin recruitment is associated with psychedelic potential.

Aggressive or uniform actions on climate targets may exacerbate regional inequality and induce economic losses in China. The proposed collaborative strategy for carbon neutrality can avoid up to 1.54% of GDP losses while 90% of provinces would gain.

By building transcontinental power pools, Yang and colleagues find global electricity demand can be 100% met by renewables, at an affordable cost.

This study reveals high variability in deforestation emission baselines typically used to derive carbon credits, with median error at 0.778 times the actual rate. It underscores the need for enhanced methods to improve carbon market accuracy and reliability.

A resilient battery electric bus transit system design and configuration is proposed. The model is robust against simultaneous charging disruptions without interrupting daily operation. Indeed, additional marginal cost is required, yet it prevents significant service reductions.

The recent accelerated expansion of glacial lakes and increased glacial lake outburst flood activities in the Tibetan Plateau and its surroundings indicate that numerous communities and infrastructure downstream are at a higher flood risk than previously understood.