Highly polarized nuclear spins can supress decoherence of electron spin qubits, but this requires near-unity polarization. Here the authors implement a protocol combining optical excitation and fast carrier tunnelling to achieve nuclear spin polarizations above 95% in GaAs quantum dots on a timescale of 1 minute.

The Higgs mode in condensed matter physics refers to the oscillations of the amplitude of the order parameter, and single Higgs modes have been studies in various systems. Here the authors report real-space observation of two coupled Higgs modes in a 1D charge density wave phase of CuTe.

Elucidating structure-function relationships is crucial for developing efficient catalysts. Here, the authors elucidate Pt single atom coordination environments on anatase TiO₂ and correlate active site structure with CO oxidation activity.

X-ray Free Electron Lasers allow fast structure determination. Here, the authors push the temporal limit of atomic level structure determination to 25 fs, the length of a single pulse, paving the way to the study of fast, non-repeatable processes.

Exceptional points emerge in systems with loss and gain when loss and gain in the system are balanced. Due to the careful balancing involved, they are highly sensitive to perturbations, making them exceptionally useful for sensors and other devices. Here, Wittrock et al observe a variety of complex dynamics associated with exceptional points in coupled spintronic nano-oscillators.

The authors found that replacing animal source foods with plant-based alternatives would lead to substantial reductions in environmental impacts, while meeting most nutrition recommendations and being cost-competitive with the current average Swedish diet.

Here, the authors show that multiyear prediction of marine habitat shifts can be skillfully accomplished by combining trait based aerobic habitat constraints with a suite of initialized retrospective Earth System Model temperature forecasts.

Modeling shows that N₂O emissions from global lakes and reservoirs have doubled since the pre-industrial era, this was mainly caused by widespread agricultural nitrogen application.

Microplastics research is often based on commercial model particles. Here, the authors show that nominally identical particles may differ significantly in their properties and thus in their interactions with cells.

Traditional mineralization of organic pollutants requires an excessive input of chemicals and causes undesirable carbon emissions. Here, authors report a nanoconfinement strategy to alter the carbon transfer pathway of phenol removal from ring opening route to oligomerization route.

Existing tools for structural variations (SVs) calling and merging often lead to fragmented SVs and the potential of introducing unnecessary errors. Here, the authors report the PanPop pipeline to address these issues by implementing sequence-aware SV merging algorithm to efficiently merge SVs of various types.

Mitochondrial biogenesis and maintenance relies on protein import from the cytosol. Here, authors show that import failure impacts organelle structure and dynamics. They also identify a rescue mechanism involving intercellular mitochondrial transfer.

Chlamydomonas reinhardtii produces a glycoprotein-rich cell wall. Using nuclear magnetic resonance and mass spectrometry approaches, this study reveals unprecedented details on its protein and carbohydrate content, and provide an atomic-level architecture model.

In this study, the authors evaluated the protective capacity of a mucosal, live-attenuated SARS-CoV-2 vaccine and show that it induces systemic and mucosal humoral immunity, protects from clinical disease symptoms, and prevents virus transmission in hamsters more efficiently than an intramuscular mRNA vaccine.

Here the authors show that a Gamma-based subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants including Omicron, induces cellular immune responses, and protects mice from infection with Omicron BA.5 SARS-CoV-2.

In this study, the authors evaluated the protective capacity of a mucosal, live-attenuated SARS-CoV-2 vaccine and show that it induces systemic and mucosal humoral immunity, protects from clinical disease symptoms, and prevents virus transmission in hamsters more efficiently than an intramuscular mRNA vaccine.

Upregulation of GLI1 of has previously been reported in sonic hedgehog (SHH) driven medulloblastoma and basal cell carcinoma (BCC). Here, the authors find that SHH-inactivation of p38 results in stabilization of the transcription factor GLI1 via dephosphorylation at Ser937, resulting in expression of SHH genes and presenting a potential therapy strategy for medulloblastoma and BCC.

The subset of chronic lymphocytic leukemia (CLL) expressing the IGLV3- 21R110 BCR light chain often shows an aggressive clinical course. Here the authors report the development and characterization of IGLV3-21R110- targeted CAR T cells, showing selective targeting and eradication of IGLV3- 21R110 expressing CLL cells.

Preclinical studies have suggested the synergistic effect of epigenetic modulators and immunotherapy. Here the authors report the results of a phase Ib/II trial of durvalumab and guadecitabine in advanced clear cell renal cell carcinoma.

Congenital heart disease is life threatening, and its screening is complex and costly. Here, authors use AI to detect the disease based on pediatric electrocardiogram, suggesting superior performance over cardiologists.

The authors found that replacing animal source foods with plant-based alternatives would lead to substantial reductions in environmental impacts, while meeting most nutrition recommendations and being cost-competitive with the current average Swedish diet.

Here the authors demonstrate that cropland expansion following the historical trend together with closing the current exploitable yield gap by half or more across Africa reduces the continent’s reliance on land conversions and imports by 2050.

Monitoring antimicrobial resistance in food animals is challenging due to limited surveillance systems. Here, the authors combine data from point prevalence surveys in lower- and middle-income settings to map resistance to seven antimicrobials and predict which are likely to exceed key resistance thresholds.

This study demonstrates the energy use of US pump irrigation produced 12.6 million tonnes CO₂e in 2018, with spatial variability modulated by water source and fuel choice. These county-level estimates can inform strategic irrigation expansion and emissions reduction efforts.

How speech sounds come to be understood as language remains unclear. Here, the authors find that brain responses to speech in part reflect abstraction of phonological units specific to the language being spoken, mediated through relationships between acoustic features.