Self-healing materials hold great promise for applications in wearable electronics, artificial muscles and soft robots but selfhealing at subzero temperatures remains a great challenge. Here, the authors present a robust subzero healable glassy polymer by incorporating polyphenol nano-assemblies with a large number of end groups into polymerizable deep eutectic solvent elastomers.

Terpene cyclases enable the synthesis of (poly)cyclic carbon frameworks via ring closure of linear polyenes. Here, the authors report in-situ formed fluorinated-alcohol-amine supramolecular clusters that mimic terpene cyclases for shape-controlled polyene cyclizations.

The synthesis of functionalizable nanographenes remains challenging. Here, the authors report that mechanochemical Scholl reaction allows access to regioselectively modifiable curved nanographenes in a high-yielding and general manner.

DFT simulations may be inaccurate in modeling aqueous systems, with results depending on the choice of the exchange-correlation functional. Here, the authors present an integrative method called HF-r²SCAN-DC4 that provides near chemical accuracy in electronic structure information not only for pure water but also for molecules dissolved in it

Boosting activity of oxide catalysts is a long-lasting challenge to developing efficient catalysts for industrially important reactions such as CO₂-to-methanol. Here, the authors report a strategy for enhancing the activity of a ZnZrO_x methanol synthesis catalyst via engineered nanoscale H supply.

Geochemical modeling shows that just a several percent expansion of O₂-free areas with toxic sulfide build-up likely contributed to biodiversity loss or reorganization during the Toarcian mass extinction 183 million years ago.

Using a large-scale 3D geodynamic model, the authors show how the transfer of subduction zone from the Pacific to the Atlantic triggered the formation of a mantle plume at the origin of the Cretaceous Caribbean Large Igneous province.

This study shows that climate change is expected to result in a 41% increase in the frequency of lightning worldwide. This increase has the potential to amplify the risk of lightning-induced wildfires.

Blue carbon benefit has not been compared among mangrove reforestation and afforestation pathways at the global scale. This study shows that mangrove reforestation could perform a greater carbon storage potential per hectare than afforestation as its higher nitrogen availability and lower salinity.

The climate crisis will increase the frequency of extreme weather events. Harrison et al. show that while global waterlogging-induced yield losses increase from 3–11% historically to 10–20% by 2080, adapting sowing periods and adopting waterlogging-tolerant genotypes can negate such yield losses.

Data on geographically restricted SARS-CoV-2 variants is lacking in some regions. In this nationwide effort including 18 public health labs, the authors used genomic epidemiology and travel data to understand the origin and spread of 2 variants of interest that predominated during the second wave of the pandemic in Nigeria.

In cell membranes, lipids are ubiquitous regulators of protein function. Here, Thakur et al. observe anionic phospholipids impact the conformational dynamics of a class A human GPCR.

Proinflammatory macrophages are involved in rheumatoid arthritis (RA). Here the authors use an efferocytosis-mimetic self-deliverable nanoimitator to mitigate RA by targeted reprogramming of synovial inflammatory macrophages, reducing proinflammatory cytokines and reinstating articular immune homeostasis.

Pachytene Piwi-interacting RNAs (piRNAs) expressed in mammalian germ lines are abundant, but their evolution and function are not fully understood. Here, the authors find that pachytene piRNA loci are hotspots of structural variation, which underlies rapid piRNA birth, divergence, and loss.

Airway epithelial repair, a key process in the recovery from lung injury, requires a metabolic shift from glycolysis to fatty acid oxidation (FAO). Pharmacological FAO promotion enhances epithelial differentiation, suggesting new therapeutic options.

The role of therapy in shaping the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) remains to be explored. Here, the authors perform single-cell RNA sequencing in PDAC samples before and after chemotherapy and suggest that chemotherapy may promote resistance to immunotherapy.

Airway epithelial repair, a key process in the recovery from lung injury, requires a metabolic shift from glycolysis to fatty acid oxidation (FAO). Pharmacological FAO promotion enhances epithelial differentiation, suggesting new therapeutic options.

Difficulty swallowing after stroke and the neural circuitry underlying this is not fully understood. Here the authors demonstrate, using a mouse model, a potential neural circuit mechanism for effects of electroacupuncture on swallowing behaviour in post-stroke dysphagia.

How the liver mitochondria seamlessly regulate lipogenesis and lipid oxidation is unknown. Here, the authors report two functionally distinct populations of mitochondria, cytoplasmic and lipid droplet-associated mitochondria, and demonstrate that the latter’s lipid oxidation function is impaired in a rat NAFLD model.

Infection with SARS-CoV-2 has been linked with substantive inflammation, lung pathology and development of COVID-19. Here the authors spatially associate CCL18 and CCL21 in distinct tissue niches with lung pathology of severe COVID-19.

Physical distancing measures introduced to control the spread of COVID-19 had socio-economic trade-offs that may have particularly impacted vulnerable population groups. Here, the authors perform a scoping review and summarise the impacts on different vulnerable groups described in 265 studies.

Here, using longitudinal survey and Twitter data, the authors examine the relationship between exposure to Russian Internet Research Agency activities on Twitter and voting behavior and attitudes in the 2016 US election.

The authors show that accurate information about descriptive norms can increase intentions to accept a vaccine for COVID-19. They show that these effects are largely consistent in the 23 included countries and are concentrated among people who were otherwise uncertain about accepting a vaccine.

Liu et al. used the NASA GRACE/FO missions to show that since 2019, groundwater depletion in California’s Central Valley has accelerated by 31% compared to recent droughts, and has increased by a nearly a factor of 5 compared to the 60-year average.

People tend to feel less empathy toward people who do not belong to their social group (outgroup members). Here, the authors show that leading people to believe that empathy is unlimited increases empathy, support for prosocial actions, and empathic behaviors toward outgroup members.