Low thermal conduction and conformability of traditional rigid heat sinks limit their adoption in flexible electronics and soft robotics. Here, authors report a liquid metal skeleton-based active-cooling elastomer with high thermal conductivity, stretchability, and hydraulic-driven adaptable morphing.

Sensitivity-dependent data analysis methods disrupted the development of artificial olfactory technologies. Here, authors present a data-centric artificial olfactory system based on eigengraph that reflects the intrinsic electrochemical interaction.

Detecting hydrogen gas in humid air is an unresolved challenge of significant importance for the safe implementation of hydrogen (energy) technologies. Here, authors demonstrate how the use of neural networks enables the sensing of hydrogen in highly humid air with a detection limit of 100 ppm.

Due to recent fluctuations in lithium prices, the instability of lithium-ion batteries prices is on the rise. Here, through a re-evaluation of purity criteria, the authors report that the presence of magnesium impurity in lithium precursor actually improves cathode performance, economics, and environmental aspects.

Micro-sized silicon are promising anode materials due to low-cost and high-energy, yet their application is hindered by inaccessible electrolytes. Here, the authors report sulfolane-based electrolytes that form silicon-phobic interphases and enable high-voltage pouch cells to achieve superior cycle life.

Abrupt millennial-scale climate variability, known as Dansgaard-Oeschger (D-O) events, characterized the last glacial. Stalagmite data from northern Türkiye show D-O events for the penultimate glacial period, though they were less frequent.

In this work, authors propose a synergistic approach combining state-of-the-art deterministic forecasting model with artificial intelligence for predicting lightning occurrences. The strategy shows efficient predictive capabilities at medium-range forecast horizons.

Soil priming could release large amounts of soil C into the atmosphere. Here the authors show that experimental warming boosts soil priming and CO₂ emissions in grasslands potentially due to microbial changes. Model accuracy could be improved by incorporating these mechanisms.

The flow of ice streams leaves traces in the stratigraphy of the ice sheets. Made visible by radar, they reveal the history of the upper North East Greenland Ice Stream. The ice stream is found to have existed in its current form for only about the last 2000 years.

West Nile Virus is emerging as an important pathogen in Europe, likely driven by recent climate and land-use changes. Here, the authors estimate the extent of the climate change-driven impact by modelling the change in West Nile Virus ecological suitability across the continent in the absence of climate change.

Genetic risk variants for autoimmune diseases are largely enriched in T cell-specific regulatory regions. In this review, Raychaudhuri and colleagues summarise the findings of recent studies evaluating the genetic regulation of T cell molecular and functional traits in these diseases.

Measles virus infection causes immunosuppression and it’s unclear whether this can be prevented by antivirals. Here, using a canine distemper virus ferret model, the authors show that measles-like immune amnesia and lethal exacerbated respiratory disease after consecutive respiratory virus infections can be mitigated by oral antiviral therapy initiated at the onset of primary clinical signs.

Here, the authors utilise an integrative approach to characterise the fuzzy heterocomplex between CXCL12 and the fully reduced alarmin HMGB1, highlighting the importance of HMGB1’s acidic IDR to the interaction and with cell surface CXCR4.

Characterising the tumour microenvironment features of lung adenocarcinoma (LUAD) remains crucial. Here, the authors perform single cell RNA sequencing data analysis of 117 LUAD samples and functional assays and highlight the immunosuppressive role of UPP1high tumour cells.

There is a need for effective antiviral drugs against RSV infection. Conducting an RSV repurposing screen using the ReFRAME library Sake et al. identify lonafarnib as an RSV fusion protein inhibitor, characterize its binding site within the viral protein and show its antiviral effects in a mouse model.

Different types of metabolic rewiring are reported to drive cancer development and as a potential therapeutic target. Here, the authors perform multi-omics analyses in a cohort of human normal and malignant thyroid samples and show association of mitochondrial one-carbon metabolism with undifferentiated thyroid cancer.

Glucocorticoids, potent anti-inflammatory drugs, can cause or exacerbate obesity, yet the underlying molecular mechanisms remain largely unknown. Here, the authors show KLF9 in macrophages integrates the beneficial anti-inflammatory and adverse metabolic effects of glucocorticoids.

Post-stroke walking impairment is a significant public health concern. Here, the authors perform an interventional, randomized controlled trial evaluating the efficacy and safety of InTandem™, an autonomous neurorehabilitation system utilizing auditory-motor entrainment to improve walking after stroke.

In this study, the authors found five disease clusters associated with a prior diagnosis of anxiety/stress-related disorders, and identified several underlying genetic components. These findings may aid mechanistic exploration and risk management for health decline among those patients.

THOC2 is an essential subunit of Transcription mRNA Export complex of eukaryotic cells and its compromise causes adverse (neuro)development. Using mouse model and patient cells the authors unravel molecular pathology of the syndrome, from R-loops dysregulation, to altered transcriptome and DNA damage triggered cell death.

Lithic cutting-edge productivity is a way of quantifying prehistoric human technological evolution. Here, the authors examine the Middle-to-Upper Paleolithic transition across eight assemblages in the eastern Mediterranean, finding the transition to be later than expected and associated with bladelet technology development.

In this work, the authors report NMR lipids Databank to promote decentralised sharing of biomolecular molecular dynamics (MD) simulation data with an overlay design. Programmatic access enables analyses of rare phenomena and advances the training of machine learning models.

Implicit biases are influenced by social contexts which, in cities, are shaped by the constraints of urban infrastructure networks. Here the authors show that more populous, more diverse, and less segregated cities are less biased and that this is predicted by a complex systems model.

Resistance to chemotherapy for soil-transmitted helminth infection has been detected in veterinary settings but not yet in human infections. Here, the authors investigate the risk of resistance in humans and how it may change as a result of scaling-up preventative deworming programs.

Here the authors find one third of global sub-basins will face severe clean water scarcity in 2050. Nitrogen pollution aggravates water scarcity in >2,000 sub-basins thus 3 billion more people will be posed with severe water scarcity in 2050.