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Welcome to Nature Communications

Nature Communications is an open access journal that publishes high-quality research in biology, physics, chemistry, Earth sciences, and all related areas.

Browse Articles

  • Article | | open

    The guanine nucleotide exchange factor SOS is a critical intermediary that transduces receptor tyrosine kinase stimulation into Ras activation. Here the authors develop a single molecule assay in which SOS is captured from raw lysates using Ras-functionalized membrane microarrays and uncover an autoinhibitory mechanism of SOS regulation.

    • Young Kwang Lee
    • , Shalini T. Low-Nam
    • , Jean K. Chung
    • , Scott D. Hansen
    • , Hiu Yue Monatrice Lam
    • , Steven Alvarez
    •  & Jay T. Groves
  • Article | | open

    The dominant male-sterile gene Ms2 has facilitated the release of hundreds of wheat-breeding lines and cultivars in China. Here Ni et al. describe the cloning of the Ms2 gene, which appears as an orphan gene in the Triticinae, and show that Ms2 can be used to confer male sterility in wheat, barley and Brachypodium.

    • Fei Ni
    • , Juan Qi
    • , Qunqun Hao
    • , Bo Lyu
    • , Ming-Cheng Luo
    • , Yan Wang
    • , Fengjuan Chen
    • , Shuyun Wang
    • , Chaozhong Zhang
    • , Lynn Epstein
    • , Xiangyu Zhao
    • , Honggang Wang
    • , Xiansheng Zhang
    • , Cuixia Chen
    • , Lanzhen Sun
    •  & Daolin Fu
  • Article | | open

    Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.

    • Esther Latres
    • , Jason Mastaitis
    • , Wen Fury
    • , Lawrence Miloscio
    • , Jesus Trejos
    • , Jeffrey Pangilinan
    • , Haruka Okamoto
    • , Katie Cavino
    • , Erqian Na
    • , Angelos Papatheodorou
    • , Tobias Willer
    • , Yu Bai
    • , Jee Hae Kim
    • , Ashique Rafique
    • , Stephen Jaspers
    • , Trevor Stitt
    • , Andrew J. Murphy
    • , George D. Yancopoulos
    •  & Jesper Gromada
  • Article | | open

    Bcl-3 modulates effector T cell responses, but the importance of Bcl-3 in T regulatory cells and autoimmunity is not clear. Here the authors show that Bcl-3 impedes NF-κB DNA binding to alter T regulatory cell development and function, causing spontaneous colitis in mice.

    • Sonja Reißig
    • , Yilang Tang
    • , Alexei Nikolaev
    • , Katharina Gerlach
    • , Christine Wolf
    • , Kathrin Davari
    • , Christian Gallus
    • , Joumana Masri
    • , Ilgiz A. Mufazalov
    • , Markus F. Neurath
    • , F. Thomas Wunderlich
    • , Jörn M. Schattenberg
    • , Peter R. Galle
    • , Benno Weigmann
    • , Ari Waisman
    • , Elke Glasmacher
    •  & Nadine Hövelmeyer
  • Article | | open

    The age of weathering inferred from bedrock saprolite local to Scandinavia remains loosely constrained. Here, via K-Ar dating of authigenic, syn-weathering illite from saprolitic remnants, the authors constrain weathering to the Late Triassic.

    • Ola Fredin
    • , Giulio Viola
    • , Horst Zwingmann
    • , Ronald Sørlie
    • , Marco Brönner
    • , Jan-Erik Lie
    • , Else Margrethe Grandal
    • , Axel Müller
    • , Annina Margreth
    • , Christoph Vogt
    •  & Jochen Knies

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