Focus
Focus on Next-Generation Sequencing
- Focus issue:
- October 2008 Volume 26, No 10
This focus summarizes the current state of the art in massively parallel sequencing technologies and how these platforms are changing the face of biological and biomedical research and of the sequencing business itself. With financial support from Roche, the focus will be freely available online from October 2008 to April 2009.
Editorial
Next-generation sequencing
Prepare for the deluge - p1099
doi:10.1038/nbt1008-1099
The gobs of data produced by next-generation sequencing are a key problem limiting wider adoption.
Abstract - | Full Text - Prepare for the deluge | PDF (132 KB) - Prepare for the deluge
News
Next-generation sequencing
Profile: Rade Drmanac - p1100
Laura DeFrancesco
doi:10.1038/nbt1008-1100
Launching the world's first commercial human genome sequencing center is currently the 'unreasonable' career ambition of sequencing-by-hybridization pioneer Rade Drmanac.
Abstract - | Full Text - Profile: Rade Drmanac | PDF (110 KB) - Profile: Rade Drmanac
News Features
Next-generation sequencing
Fixing the front end - pp1101 - 1104
Ken Garber
doi:10.1038/nbt1008-1101
One bottleneck in next-generation sequencing is genomic sample selection. As research groups tackle the problem, companies are seizing a market opportunity. Ken Garber reports.
Abstract - | Full Text - Fixing the front end | PDF (163 KB) - Fixing the front end
Next-generation sequencing
What price personal genome exploration? - pp1105 - 1108
Jeffrey L Fox
doi:10.1038/nbt1008-1105
Companies offering direct-to-consumer genomic information face tough questions about who regulates them, where they fit in health care and how to value their services. What will it take to move them from niche services to a broader customer base? Jeffrey Fox reports.
Abstract - | Full Text - What price personal genome exploration? | PDF (390 KB) - What price personal genome exploration?
Next-generation sequencing
The sequencing shakeup - pp1109 - 1112
Amy Coombs
doi:10.1038/nbt1008-1109
Deep sequencing technology could soon be competitive with certain array applications. But the jury remains out on which of the myriad platforms will have the greatest impact and broadest application. Amy Coombs investigates.
Abstract - | Full Text - The sequencing shakeup | PDF (170 KB) - The sequencing shakeup
Opinion and Comment
Commentary
Next-generation sequencing
How to get genomes at one ten-thousandth the cost - pp1113 - 1115
Jeffery A Schloss
doi:10.1038/nbt1008-1113
The NHGRI's Advanced DNA Sequencing Technology program is spearheading the development of platforms that will bring routine whole-genome sequencing closer to reality.
Abstract - | Full Text - How to get genomes at one ten-thousandth the cost
Research
Perspectives
Next-generation sequencing
The development and impact of 454 sequencing - pp1117 - 1124
Jonathan M Rothberg & John H Leamon
doi:10.1038/nbt1485
Abstract - | Full Text - The development and impact of 454 sequencing | PDF (583 KB) - The development and impact of 454 sequencing
Next-generation sequencing
What would you do if you could sequence everything? - pp1125 - 1133
Avak Kahvejian, John Quackenbush & John F Thompson
doi:10.1038/nbt1494
Abstract - | Full Text - What would you do if you could sequence everything? | PDF (908 KB) - What would you do if you could sequence everything?
Reviews
Next-generation sequencing
Next-generation DNA sequencing - pp1135 - 1145
Jay Shendure & Hanlee Ji
doi:10.1038/nbt1486
Abstract - | Full Text - Next-generation DNA sequencing | PDF (694 KB) - Next-generation DNA sequencing
Next-generation sequencing
The potential and challenges of nanopore sequencing - pp1146 - 1153
Daniel Branton, David W Deamer, Andre Marziali, Hagan Bayley, Steven A Benner, Thomas Butler, Massimiliano Di Ventra, Slaven Garaj, Andrew Hibbs, Xiaohua Huang, Stevan B Jovanovich, Predrag S Krstic, Stuart Lindsay, Xinsheng Sean Ling, Carlos H Mastrangelo, Amit Meller, John S Oliver, Yuriy V Pershin, J Michael Ramsey, Robert Riehn, Gautam V Soni, Vincent Tabard-Cossa, Meni Wanunu, Matthew Wiggin & Jeffery A Schloss
doi:10.1038/nbt.1495
Abstract - | Full Text - The potential and challenges of nanopore sequencing | PDF (1,791 KB) - The potential and challenges of nanopore sequencing