Nature Biotechnology

Multi-immersion mirror objectives

Neurons in the mouse hippocampus imaged with the Schmidt objective. Voigt et al. develop a multi-immersion objective based on a mirror instead of a lens.

Current issue

Tearing up the traditional biotech playbook

Editorial08 Jan 2024
The world’s first CRISPR therapy is approved: who will receive it?

Cormac Sheridan
News21 Nov 2023
First self-amplifying mRNA vaccine approved

News in Brief17 Jan 2024
Dandelion uses the single-cell adaptive immune receptor repertoire to explore lymphocyte developmental origins

Chenqu Suo
Krzysztof Polanski
Sarah A. Teichmann
ArticleOpen Access13 Apr 2023
DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins

Yu-Hang Xing
Rui Dong
Miguel N. Rivera
ArticleOpen Access10 Apr 2023
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

Fabian F. Voigt
Anna Maria Reuss
Fritjof Helmchen
ArticleOpen Access30 Mar 2023

Contents

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Announcements

Super-resistant CAR Ts take on cancers

Sophisticated genome editing tools to tweak multiple genes in one step are forging a first-of-its-kind generation of universal CAR T therapeutics, while ‘epitope-edited’ and virus-free manufacturing aim to democratize CAR T cells’ clinical uptake worldwide.
Reducing cell & gene therapy costs in the Global South

Researchers in low- and middle-income countries are developing their own IP, scaling up local manufacturing, and looking for biomarkers — all in the hope of bringing costs down and getting therapies to people who need them.

Nature Biotechnology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Latest Research articles

Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition

A new mass spectrometry strategy combines the advantages of data-dependent and data-independent acquisition.

Ulises H. Guzman
Ana Martinez-Val
Jesper V. Olsen
ArticleOpen Access01 Feb 2024
Activation of recombinases at specific DNA loci by zinc-finger domain insertions

Recombinases fused with zinc-finger domains are active only when bound to their DNA targets.

Liliya Mukhametzyanova
Lukas Theo Schmitt
Frank Buchholz
ArticleOpen Access31 Jan 2024
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution

Computationally designed sensors map the activity and signaling environment of Ras.

Jason Z. Zhang
William H. Nguyen
David Baker
ArticleOpen Access25 Jan 2024
Slow release of a synthetic auxin induces formation of adventitious roots in recalcitrant woody plants

Adventitious roots are induced in various woody plants, enabling clonal propagation.

Ohad Roth
Sela Yechezkel
Roy Weinstain
Article24 Jan 2024
Mosaic integration and knowledge transfer of single-cell multimodal data with MIDAS

Single-cell, multiomic datasets are integrated using dimensionality reduction, imputation and batch correction.

Zhen He
Shuofeng Hu
Xiaomin Ying
ArticleOpen Access23 Jan 2024
Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids

Electrical activity in neural organoids is captured with a device inspired by a paper-cutting art.

Xiao Yang
Csaba Forró
Bianxiao Cui
Article22 Jan 2024

Latest Reviews & Analysis

- A conditional, zinc-finger-dependent recombinase system for DNA editing
  
  By applying the logic of conditional enzymes, we have developed a zinc-finger-dependent recombinase system, the editing activity of which is induced by zinc finger DNA binding. The system combines the precision of recombinases with the DNA target site programmability of zinc finger domains.
  
  Research Briefing01 Feb 2024
- A new mass analyzer shakes up the proteomics field
  
  A new mass analyzer enables protein identification at high speed and depth.
  Bernhard Kuster
  Johanna Tüshaus
  Florian P. Bayer
  
  News & Views01 Feb 2024
- Medicare price negotiation and pharmaceutical innovation following the Inflation Reduction Act
  
  A retrospective analysis shows that the IRA will not result in a large-scale defunding of biopharmaceutical innovation.
  Matthew Vogel
  Pragya Kakani
  Rena M. Conti
  
  Perspective31 Jan 2024
- An optimized toolkit for prime editing
  
  Prime editing in vivo is systematically improved with an eye to clinical translation.
  Ryan M. Marks
  Ori Scott
  Ronald D. Cohn
  
  News & Views29 Jan 2024
- Computer-based design of sensors that can monitor endogenous Ras activity
  
  Many questions on the activity of the Ras proto-oncogene are unanswered due to the lack of tools for detecting active Ras in living cells. Here, we used protein design and structure prediction algorithms to develop biosensors that detect the activity and environment of endogenous Ras.
  
  Research Briefing25 Jan 2024
- A synthetic auxin for cloning mature trees
  Catherine Bellini
  
  News & Views24 Jan 2024
- Eavesdropping on brain organoids
  James Newton Brandt
  Priya Rajasethupathy
  
  News & Views22 Jan 2024
- KARR-seq maps higher-order RNA structures and RNA–RNA interactions across the transcriptome
  
  Research Briefing18 Jan 2024
- Wearable ultrasound for continuous deep-tissue monitoring
  Jon-Emile S. Kenny
  
  News & Views16 Jan 2024

News & Comment

Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy

Delphine Larivière
Linelle Abueg
Giulio Formenti
Correspondence26 Jan 2024
The perpetual motion machine of AI-generated data and the distraction of ChatGPT as a ‘scientist’

Jennifer Listgarten
Correspondence25 Jan 2024
First self-amplifying mRNA vaccine approved

News in Brief17 Jan 2024
N¹-methylpseudouridylation affects the fidelity of mRNA translation

Rong Li
Research Highlight17 Jan 2024
Denmark invests in mucosal vaccines

News in Brief17 Jan 2024
Top biopharmas’ zero-carbon drive

News in Brief17 Jan 2024

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Science jobs

Southern University of Science and Technology Welcomes Outstanding Young Talents Worldwide

Southern University of Science and Technology invites global talents for our National Science Fund Program for Outstanding Young Scholars application

China (CN)

Southern University of Science and Technology(SUSTech)
Postdoctoral Fellowships at West China Hospital/West China School of Medicine of Sichuan University

Open to PhD students, PhD, Post-Doc and residents.

Chengdu, Sichuan, China

West China School of Medicine/West China Hospital
Research Technician / Senior Research Technician in CRISPRscreens with Transcriptomic Readouts

Job description APPLICATION CLOSING DATE: February 16th, 2024 About Human Technopole (HT) Human Technopole (HT) is an interdisciplinary life scie...

Milan (IT)

Human Technopole
Postdoc in Functional Genomics for Anti-Cancer Therapeutic Target Discovery

Job description APPLICATION CLOSING DATE: February 16th, 2024 Human Technopole (HT) is a new interdisciplinary life science research institute cr...

Milan (IT)

Human Technopole
Technician Bienko Group

Job description APPLICATION CLOSING DATE: February, 18th, 2024 Human Technopole (HT) is an interdisciplinary life science research institute, creat...

Milan (IT)

Human Technopole

Announcements

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Fast and accurate identification of plasmids and viruses in sequencing data using geNomad

Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy

In vivo human T cell engineering with enveloped delivery vehicles

Activation of recombinases at specific DNA loci by zinc-finger domain insertions

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