Nature Biotechnology

Color-enhanced image showing single-cell fluorescence measurements of protein and mRNA in the human lymph node.

Spatial molecular imaging

Hundreds of RNAs and proteins are imaged in fixed tissue at subcellular resoltuion

Current issue

Global health equity: the next waiver

Editorial 07 Dec 2022
TYK2-blocking agent showcases power of atypical kinase

Elie Dolgin
News 07 Dec 2022
Alzheimer’s space heats up

News in Brief 07 Dec 2022
Enhancing untargeted metabolomics using metadata-based source annotation

Julia M. Gauglitz
Kiana A. West
Pieter C. Dorrestein
Brief Communication 07 Jul 2022
High-throughput total RNA sequencing in single cells using VASA-seq

Fredrik Salmen
Joachim De Jonghe
Alexander van Oudenaarden
Article Open Access 27 Jun 2022
High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging

Shanshan He
Ruchir Bhatt
Joseph M. Beechem
Article 06 Oct 2022

Contents

View all issues

Announcements

Biopharmaceutical benchmarks 2022

Monoclonal antibodies as a group continue to lead biopharmaceuticals in numbers of approvals and sales, although COVID-19 vaccines shot to the top of the list of highest-grossing individual products.
Nature Biotechnology’s academic spinouts 2021

Our annual survey highlights academic startups that are, among other things, designing circular RNA therapeutics, tackling cancer with arenaviruses, creating psychedelics without the trip, editing genes and cells in vivo, harnessing the power of auto-antibodies, editing the epigenome.
Wanted: Genomics editor

We're seeking a researcher to join our team as an Associate or Senior Editor. Candidates must have a PhD in an area relevant to genomics, with knowledge of single cell, gene editing, microbiology, plant biotechnology or genomics, and epigenetics a plus.
Wanted: Immunology editor

We're seeking a researcher to join our team as an Associate or Senior Editor. Candidates must have a PhD in an area relevant to immunology.

Nature Biotechnology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Latest Research articles

Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag

Three epigenetic features are mapped at single-cell resolution using Tn5-nanobody fusion proteins

Marek Bartosovic
Gonçalo Castelo-Branco
Article Open Access 19 Dec 2022
Nanobody-tethered transposition enables multifactorial chromatin profiling at single-cell resolution

Cell surface protein expression and multiple epigenetic features are mapped simultaneously in single cells.

Tim Stuart
Stephanie Hao
Ivan Raimondi
Article 19 Dec 2022
Functional analysis of structural variants in single cells using Strand-seq

Linking structural variants to gene expression information identifies aberrant signaling pathways.

Hyobin Jeong
Karen Grimes
Jan O. Korbel
Article Open Access 24 Nov 2022
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

A wireless ‘smart’ bandage stimulates wound healing.

Yuanwen Jiang
Artem A. Trotsyuk
Zhenan Bao
Article 24 Nov 2022
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Large sequences are integrated site specifically into the human genome without double-strand DNA cleavage.

Matthew T. N. Yarnall
Eleonora I. Ioannidi
Jonathan S. Gootenberg
Article 24 Nov 2022
High-throughput retrieval of target sequences from complex clone libraries using CRISPRi

A CRISPRi method retrieves sequences of interest from large metagenomic libraries.

Ján Burian
Vincent K. Libis
Sean F. Brady
Brief Communication 21 Nov 2022

Latest Reviews & Analysis

- Multiplexed mapping of chromatin features at single-cell resolution
  
  Single-cell nanobody-tethered transposition followed by sequencing (scNTT-seq) is a new assay that measures the genome-wide presence of multiple histone modifications and protein–DNA binding sites at single-cell resolution. scNTT-seq generates high-resolution multimodal maps of chromatin states with high accuracy and sensitivity.
  
  Research Briefing 19 Dec 2022
- Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity
  
  Nanobody–Tn5 transposase fusion proteins enable detection of two histone marks and open chromatin regions at the same time, with single-cell resolution.
  
  Research Briefing 19 Dec 2022
- Novel recombinases for large DNA insertions
  
  Bioinformatic mining and engineering of serine recombinases yields improved genome editing tools.
  George D. Lampe
  Samuel H. Sternberg
  
  News & Views 24 Nov 2022
- Single-cell multi-omics allows functional characterization of structural variants
  
  We developed a computational method based on Strand-seq that combines nucleosome occupancy and structural variation analysis in single cells to identify the functional effects of somatic structural variants in leukemia. The method revealed the molecular consequences of somatic driver mutations and informed specific therapeutic targeting of a chromothriptic leukemic subclone.
  
  Research Briefing 24 Nov 2022
- Healing chronic wounds with a wireless smart bandage with integrated sensors and stimulators
  
  We developed a wireless smart bandage with sensors that can detect the condition of a wound and stimulators that can deliver electric cues. Application of our device on wounds in mouse models reduced infection and accelerated wound healing.
  
  Research Briefing 24 Nov 2022
- Rapid mining of (meta)genomic biodiversity by repurposing CRISPRi for positive selection
  
  Research Briefing 21 Nov 2022
- Optical microscopy gets down to angstroms
  Giorgio Tortarolo
  Suliana Manley
  
  News & Views 07 Nov 2022
- Profiling chromatin–protein crosstalk at locus resolution in single cells
  
  Research Briefing 07 Nov 2022
- Synthetic biologics provide a path to target bHLH transcription factors
  
  Research Briefing 03 Nov 2022

News & Comment

Exploring the value of a global gene drive project registry

Riley I. Taitingfong
Cynthia Triplett
Cinnamon S. Bloss
Correspondence 15 Dec 2022
How to grow (almost) anything: a hybrid distance learning model for global laboratory-based synthetic biology education

A pilot program for synthetic biology education via a scalable distributed network model of distance-based laboratory learning can be accessible globally across disciplines and backgrounds.

Eyal Perry
Jessica Weber
David Kong
Career Feature 12 Dec 2022
Pompe disease treated before birth

News in Brief 07 Dec 2022
Genotoxins from gut bacteria

Isobel Leake
Research Highlight 07 Dec 2022
Imaging epigenomics in the brain

Katharine H. Wrighton
Research Highlight 07 Dec 2022
Noma: from grasshopper brews to age-old ‘garum’

Lisa Melton
News 07 Dec 2022

Trending - Altmetric

Events

Fibrosis Pathogenesis and Resolution: From Mechanisms to Therapies

19 March 2023 – 23 March 2023
Fairmont Banff Springs
EMBO | EMBL Symposium: Cellular mechanics of symbiosis

29 March 2023 – 31 March 2023
EMBL Advanced Training Centre
Innate Immunity: From Innate Sensing to Adaptive Responses

16 April 2023 – 19 April 2023
Snowbird Resort
EMBL Conference: Protein synthesis and translational control

05 September 2023 – 10 September 2023
EMBL Advanced Training Centre
EMBO | EMBL Symposium: Brain genome: regulation, evolution and function

25 April 2023 – 28 April 2023
EMBL Advanced Training Centre

Jobs

Student Help for VR Annotation (f/m/x)

Helmholtz Munich
Neuherberg (bei München), Germany
Postdoctoral fellow, the physiological and molecular bases of social behavior in bees

Hebrew University of Jerusalem (HUJI)
Jerusalem, Israel
Lecturer/Assistant Professor/Associate Professor in Bioengineering

Nanyang Technological University (NTU)
Singapore, Singapore
Assistant Professorship (non tenure track) for Clinical Immunology 100%

University of Zurich
Zurich, Switzerland
PhD Positions in Mechanical Engineering

The University of British Columbia (UBC)
Vancouver, Canada

Announcements

Advertisement

Trending - Altmetric

Identification of antimicrobial peptides from the human gut microbiome using deep learning

How to grow (almost) anything: a hybrid distance learning model for global laboratory-based synthetic biology education

Exploring the value of a global gene drive project registry

Nanobody-tethered transposition enables multifactorial chromatin profiling at single-cell resolution

Search

Quick links