Nature Biotechnology

The structure of carbonic anhydrase in front of a background composed of amino acid letters representing sequence data.

Focus on protein engineering

Current issue

Spotlight on protein structure design

Editorial15 Feb 2024
Can single-cell biology realize the promise of precision medicine?

Cormac Sheridan
News15 Feb 2024
First desmoid tumor drug

News in Brief15 Feb 2024
Generative models for protein structures and sequences

Chloe Hsu
Clara Fannjiang
Jennifer Listgarten
Primer15 Feb 2024
Designing proteins with language models

Jeffrey A. Ruffolo
Ali Madani
Primer15 Feb 2024
Sparks of function by de novo protein design

Alexander E. Chu
Tianyu Lu
Po-Ssu Huang
Review Article15 Feb 2024

Contents

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Announcements

Super-resistant CAR Ts take on cancers

Sophisticated genome editing tools to tweak multiple genes in one step are forging a first-of-its-kind generation of universal CAR T therapeutics, while ‘epitope-edited’ and virus-free manufacturing aim to democratize CAR T cells’ clinical uptake worldwide.
Reducing cell & gene therapy costs in the Global South

Researchers in low- and middle-income countries are developing their own IP, scaling up local manufacturing, and looking for biomarkers — all in the hope of bringing costs down and getting therapies to people who need them.

Nature Biotechnology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Latest Research articles

All-atom RNA structure determination from cryo-EM maps

RNA structures are built from cryogenic electron microscopy maps using deep learning and backbone tracing.

Tao Li
Jiahua He
Sheng-You Huang
Article23 Feb 2024
Quality assessment of gene repertoire annotations with OMArk

A new tool checks the quality of gene annotations in genome sequences.

Yannis Nevers
Alex Warwick Vesztrocy
Natasha M. Glover
ArticleOpen Access21 Feb 2024
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Transgenes are inserted into human cells by 2-RNA delivery of a retroelement protein and template.

Xiaozhu Zhang
Briana Van Treeck
Kathleen Collins
ArticleOpen Access20 Feb 2024
An oncolytic virus–T cell chimera for cancer immunotherapy

Oncolytic adenovirus is delivered on T cells and engineered to express a checkpoint inhibitor.

Yuxuan Chen
Xiaohong Chen
Yuan Ping
Article09 Feb 2024
Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq

SIMPLE-seq measures both 5-methylcytosine and 5-hydroxymethylcytosine at base resolution in single cells.

Dongsheng Bai
Xiaoting Zhang
Chengqi Yi
Article09 Feb 2024
Simultaneous nanopore profiling of mRNA m⁶A and pseudouridine reveals translation coordination

A machine learning pipeline for nanopore sequencing analyzes m⁶A and Ψ simultaneously.

Sihao Huang
Adam C. Wylder
Tao Pan
Brief Communication06 Feb 2024

Latest Reviews & Analysis

- A deep learning-based method for modeling of RNA structures from cryo-EM maps
  
  We developed a deep learning-based method, EMRNA, to automatically model RNA structures from cryo-electron microscopy maps. Evaluation of EMRNA on diverse test sets of RNA maps shows that it builds RNA models with high accuracy and efficiency.
  
  Research Briefing23 Feb 2024
- OMArk, a tool for gene annotation quality control, reveals erroneous gene inference
  
  We developed the OMArk software package for evaluating protein-coding gene annotation quality. In addition to assessing the completeness of a proteome, OMArk estimates the overall quality of the gene set’s content, a feature that will help to improve public protein sequence data.
  
  Research Briefing21 Feb 2024
- Designing proteins with language models
  
  Protein language models learn from diverse sequences spanning the evolutionary tree and have proven to be powerful tools for sequence design, variant effect prediction and structure prediction. What are the foundations of protein language models, and how are they applied in protein engineering?
  Jeffrey A. Ruffolo
  Ali Madani
  
  Primer15 Feb 2024
- Generative models for protein structures and sequences
  
  Models like ChatGPT and DALL-E2 generate text and images in response to a text prompt. Despite different data and goals, how can generative models be useful for protein engineering?
  Chloe Hsu
  Clara Fannjiang
  Jennifer Listgarten
  
  Primer15 Feb 2024
- Sparks of function by de novo protein design
  
  Chu and colleagues discuss recent developments in de novo protein design.
  Alexander E. Chu
  Tianyu Lu
  Po-Ssu Huang
  
  Review Article15 Feb 2024
- Machine learning for functional protein design
  Pascal Notin
  Nathan Rollins
  Debora Marks
  
  Review Article15 Feb 2024
- Computational drug development for membrane protein targets
  Haijian Li
  Xiaolin Sun
  Horst Vogel
  
  Review Article15 Feb 2024
- A conditional, zinc-finger-dependent recombinase system for DNA editing
  
  Research Briefing01 Feb 2024
- A new mass analyzer shakes up the proteomics field
  Bernhard Kuster
  Johanna Tüshaus
  Florian P. Bayer
  
  News & Views01 Feb 2024

News & Comment

Forum: Deane and Grigoryan

Podcast15 Feb 2024
First desmoid tumor drug

News in Brief15 Feb 2024
Boosting circulating tumor DNA to improve liquid biopsies

Iris Marchal
Research Highlight15 Feb 2024
Row over Curie building ends on a high note

Michael Francisco
News15 Feb 2024
A new class of antibiotics acts as molecular glue

Iris Marchal
Research Highlight15 Feb 2024
Protein engineering and design

Recent patents relating to systems and methods for designing engineered polypeptides.

Patents15 Feb 2024

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Science jobs

Recruitment of Global Talent at the Institute of Zoology, Chinese Academy of Sciences (IOZ, CAS)

The Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS), is seeking global talents around the world.

Beijing, China

Institute of Zoology, Chinese Academy of Sciences (IOZ, CAS)
Faculty Positions in School of Engineering, Westlake University

Tenured or tenure-track faculty positions in all ranks. We seek candidates with research interests in multiple areas.

Yungu, Hangzhou, Zhejiang, China

School of Engineering, Westlake University
Mass Spectrometry Imaging Specialist

Rutgers, The State University of New Jersey, is seeking a Mass Spectrometry Imaging (MSI) Specialist for the Center for Advanced Proteomics Research.

Newark, New Jersey

Rutgers Health
Southern University of Science and Technology Welcomes Outstanding Young Talents Worldwide

Southern University of Science and Technology invites global talents for our National Science Fund Program for Outstanding Young Scholars application

China (CN)

Southern University of Science and Technology(SUSTech)
Postdoctoral Fellowships at West China Hospital/West China School of Medicine of Sichuan University

Open to PhD students, PhD, Post-Doc and residents.

Chengdu, Sichuan, China

West China School of Medicine/West China Hospital

Announcements

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Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Designing proteins with language models

Sparks of function by de novo protein design

Computational drug development for membrane protein targets

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