Mining antibodies with droplet microfluidics

Millions of primary IgG-secreting cells from mouse and human are characterized for activity and antibody sequence at the single-cell level

Featured Content

The app credibility gap

A slew of national COVID-19 exposure apps have failed because of poor public engagement and acceptance. Apps from the workplace may offer a partial solution if privacy can be guaranteed.
Coronavirus vaccine developers wary of errant antibodies

Concerns persist that COVID-19 vaccines could cause antibody-dependent enhancement, which can potentiate viral entry into host cells and worsen disease.
Podcast: Katrine Bosley

Katrine Bosley, former CEO of Editas Medicines and Avila Therapeutics, discusses growing up in Ohio, her first job in biotech (as an administrative assistant) and why her five years at Editas felt more like 1,000. This episode is part of Nature Biotechnology's upcoming focus issue on translating the CRISPR technology.
The biopharmaceutical anomaly

Investment and funding has continued to flow into biotech, unlike most business sectors. But with healthcare and hospital budgets increasingly under pressure, do belt-tightening and consolidation lie ahead?

Current Issue | June 2020

Latest Research

Letter | 06 July 2020

Targeted, efficient sequence insertion and replacement in rice

Rice genes are replaced using chemically modified donor DNA and CRISPR targeting.
- Yuming Lu
- , Yifu Tian
- , Rundong Shen
- , Qi Yao
- , Mugui Wang
- , Mei Chen
- , Jinsong Dong
- , Tongen Zhang
- , Feng Li
- , Mingguang Lei
- & Jian-Kang Zhu
Article | 06 July 2020

A dual-constriction biological nanopore resolves homonucleotide sequences with high fidelity

Equipping a protein nanopore with a second constriction improves sequencing of homopolymer DNA stretches.
- Sander E. Van der Verren
- , Nani Van Gerven
- , Wim Jonckheere
- , Richard Hambley
- , Pratik Singh
- , John Kilgour
- , Michael Jordan
- , E. Jayne Wallace
- , Lakmal Jayasinghe
- & Han Remaut
Letter | 06 July 2020

Sequence-specific prediction of the efficiencies of adenine and cytosine base editors

The activity of adenine or cytosine base editors at specific target nucleotides is predicted computationally.
- Myungjae Song
- , Hui Kwon Kim
- , Sungtae Lee
- , Younggwang Kim
- , Sang-Yeon Seo
- , Jinman Park
- , Jae Woo Choi
- , Hyewon Jang
- , Jeong Hong Shin
- , Seonwoo Min
- , Zhejiu Quan
- , Ji Hun Kim
- , Hoon Chul Kang
- , Sungroh Yoon
- & Hyongbum Henry Kim
Article | 06 July 2020

Cell-free biosensors for rapid detection of water contaminants

Water contaminants are detected with freeze-dried, regulated in vitro transcription reactions.
- Jaeyoung K. Jung
- , Khalid K. Alam
- , Matthew S. Verosloff
- , Daiana A. Capdevila
- , Morgane Desmau
- , Phillip R. Clauer
- , Jeong Wook Lee
- , Peter Q. Nguyen
- , Pablo A. Pastén
- , Sandrine J. Matiasek
- , Jean-François Gaillard
- , David P. Giedroc
- , James J. Collins
- & Julius B. Lucks
Review Article | 29 June 2020

The delivery challenge: fulfilling the promise of therapeutic genome editing

As CRISPR therapies move into clinical testing, David Schaffer and colleagues review a raft of different delivery technologies being road tested to address cargo capacity limitations, maximize potency, minimize off-target effects and avoid immunogenicity.
- Joost van Haasteren
- , Jie Li
- , Olivia J. Scheideler
- , Niren Murthy
- & David V. Schaffer
Article | 29 June 2020

Programmable m⁶A modification of cellular RNAs with a Cas13-directed methyltransferase

The most abundant RNA modification in humans, m⁶A, can be installed at specified RNA sequences in cells, enabling functional studies.
- Christopher Wilson
- , Peter J. Chen
- , Zhuang Miao
- & David R. Liu

More Latest Research

News & Comment

Feature | 30 June 2020

The biopharmaceutical anomaly

Investment and funding has continued to flow into biotech, unlike most business sectors. But with healthcare and hospital budgets increasingly under pressure, do belt-tightening and consolidation lie ahead? Melanie Senior investigates, with additional reporting by Riku Lähteenmäki.
- Melanie Senior
Editorial | 26 June 2020

The app credibility gap

A slew of national COVID-19 exposure apps have failed because of poor public engagement and acceptance. Apps from the workplace may offer a partial solution if privacy can be guaranteed.
News Feature | 23 June 2020

The hothouse for protein design

The University of Washington’s Institute for Protein Design has become a hub to galvanize de novo protein engineering, citizen science and much more since its founding in 2012.
- Caroline Seydel
Correspondence | 18 June 2020

Blueprint for a pop-up SARS-CoV-2 testing lab
- Alexandra M. Amen
- , Kerrie W. Barry
- , John M. Boyle
- , Cara E. Brook
- , Seunga Choo
- , L. T. Cornmesser
- , David J. Dilworth
- , Jennifer A. Doudna
- , Alexander J. Ehrenberg
- , Indro Fedrigo
- , Skyler E. Friedline
- , Thomas G. W. Graham
- , Ralph Green
- , Jennifer R. Hamilton
- , Ariana Hirsh
- , Megan L. Hochstrasser
- , Dirk Hockemeyer
- , Netravathi Krishnappa
- , Azra Lari
- , Hanqin Li
- , Enrique Lin-Shiao
- , Tianlin Lu
- , Elijah F. Lyons
- , Kevin G. Mark
- , Lisa Argento Martell
- , A. Raquel O. Martins
- , Shana L. McDevitt
- , Patrick S. Mitchell
- , Erica A. Moehle
- , Christine Naca
- , Divya Nandakumar
- , Elizabeth O’Brien
- , Derek J. Pappas
- , Kathleen Pestal
- , Diana L. Quach
- , Benjamin E. Rubin
- , Rohan Sachdeva
- , Elizabeth C. Stahl
- , Abdullah Muhammad Syed
- , I-Li Tan
- , Amy L. Tollner
- , Connor A. Tsuchida
- , C. Kimberly Tsui
- , Timothy K. Turkalo
- , Fyodor D. Urnov
- , M. Bryan Warf
- , Oscar N. Whitney
- & Lea B. Witkowsky
Correspondence | 18 June 2020

Scalable and robust SARS-CoV-2 testing in an academic center
- Jim Aitken
- , Karen Ambrose
- , Sam Barrell
- , Rupert Beale
- , Ganka Bineva-Todd
- , Dhruva Biswas
- , Richard Byrne
- , Simon Caidan
- , Peter Cherepanov
- , Laura Churchward
- , Graham Clark
- , Margaret Crawford
- , Laura Cubitt
- , Vicky Dearing
- , Christopher Earl
- , Amelia Edwards
- , Chris Ekin
- , Efthymios Fidanis
- , Alessandra Gaiba
- , Steve Gamblin
- , Sonia Gandhi
- , Jacki Goldman
- , Robert Goldstone
- , Paul R. Grant
- , Maria Greco
- , Judith Heaney
- , Steve Hindmarsh
- , Catherine F. Houlihan
- , Michael Howell
- , Michael Hubank
- , Deborah Hughes
- , Rachael Instrell
- , Deborah Jackson
- , Mariam Jamal-Hanjani
- , Ming Jiang
- , Mark Johnson
- , Leigh Jones
- , Nnennaya Kanu
- , George Kassiotis
- , Stuart Kirk
- , Svend Kjaer
- , Andrew Levett
- , Lisa Levett
- , Marcel Levi
- , Wei-Ting Lu
- , James I. MacRae
- , John Matthews
- , Laura E. McCoy
- , Catherine Moore
- , David Moore
- , Eleni Nastouli
- , Jerome Nicod
- , Luke Nightingale
- , Jessica Olsen
- , Nicola O’Reilly
- , Amar Pabari
- , Venizelos Papayannopoulos
- , Namita Patel
- , Nigel Peat
- , Marc Pollitt
- , Peter Ratcliffe
- , Caetano Reis e Sousa
- , Annachiara Rosa
- , Rachel Rosenthal
- , Chloe Roustan
- , Andrew Rowan
- , Gee Yen Shin
- , Daniel M. Snell
- , Ok-Ryul Song
- , Moira J. Spyer
- , Amy Strange
- , Charles Swanton
- , James M. A. Turner
- , Melanie Turner
- , Andreas Wack
- , Philip A. Walker
- , Sophia Ward
- , Wai Keong Wong
- , Joshua Wright
- & Mary Wu
Correspondence | 17 June 2020

Regulatory centaurs
- Peter J. Pitts