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Cover Credit: PANoptosis is a new type of cell death featured with pyroptosis, apoptosis and necroptosis as a result of PANoptosome formation. The core components of PANoptosome are CASP8 and RIPK3. The picture is a fluorescence microscopic visualization of the PANoptosome formed in macrophages which can be inhibited by inhibitors of reverse electron transport. Doi: 10.1038/s41401-023-01182-8. See the article in pages 594–608