Volume 45 Issue 2, February 2024

Cover Credit: Schematic illustration of possible mechanisms contributing to curcumin against desipramine-induced apoptosis and insulin secretion impairment. Curcumin could inhibit the binding of AKAP150 to PP2B and the phosphorylation of synapsin 1 induced by desipramine, and suppress desipramine-induced insulin secretion impairment. Moreover, curcumin could inhibit desipramine-induced apoptosis through PI3K/AKT/FOXO1 signaling pathway. (DOI 10.1038/s41401-023-01176-6). See the article in pages 327–338