RNA metabolism

Definition

RNA metabolism refers to any events in the life cycle of ribonucleic acid (RNA) molecules, including their synthesis, folding/unfolding, modification, processing and degradation.

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Latest Research and Reviews

  • Reviews |

    Non-coding RNAs (ncRNAs) are functional molecules that regulate physiological programmes in developmental and disease contexts. This Review article discusses the complex networks of interactions that ncRNAs engage in and how these confer oncogenic or tumour-suppressive effects in cancer.

    • Eleni Anastasiadou
    • , Leni S. Jacob
    •  & Frank J. Slack
  • Reviews |

    Structures in 5′ untranslated regions of eukaryotic mRNAs contribute to gene regulation by controlling cap-dependent and cap-independent translation initiation through diverse mechanisms. New structure probing technologies coupled with techniques such as compensatory mutagenesis will likely identify new structured RNA elements and help elucidate their function.

    • Kathrin Leppek
    • , Rhiju Das
    •  & Maria Barna
  • Research |

    A high-resolution structure of the human ribosome determined by cryo-electron microscopy visualizes numerous RNA modifications that are concentrated at functional sites with an extended shell, and suggests the possibility of designing more specific ribosome-targeting drugs.

    • S. Kundhavai Natchiar
    • , Alexander G. Myasnikov
    • , Hanna Kratzat
    • , Isabelle Hazemann
    •  & Bruno P. Klaholz
    Nature 551, 472–477
  • Research | | open

    Environmental adaptation is generally studied at the genomic level, but it may also be driven by transcriptional processes. Here, the authors investigate variation in gene expression and RNA editing across diverging populations of Drosophila melanogaster from two microclimates.

    • Arielle L. Yablonovitch
    • , Jeremy Fu
    • , Kexin Li
    • , Simpla Mahato
    • , Lin Kang
    • , Eugenia Rashkovetsky
    • , Abraham B. Korol
    • , Hua Tang
    • , Pawel Michalak
    • , Andrew C. Zelhof
    • , Eviatar Nevo
    •  & Jin Billy Li
  • Research | | open

    The mitochondrial genome, being compressed to 16 kb, is an attractive model system to investigate how RNA-binding proteins chaperone mRNA lifecycles. Here the authors use RNase footprinting and PAR-CLIP to show that the LRPPRC–SLIRP complex stabilizes mRNA structures to expose sites required for translation and polyadenylation.

    • Stefan J. Siira
    • , Henrik Spåhr
    • , Anne-Marie J. Shearwood
    • , Benedetta Ruzzenente
    • , Nils-Göran Larsson
    • , Oliver Rackham
    •  & Aleksandra Filipovska

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