RNA decay articles from across Nature Portfolio

Research on Arabidopsis indicates that RNA decay, PTGS pathway, GC content, and spatial-temporal gene expression impact ct-siRNA production, vital for gene silencing during plant growth and stress responses.

This study analyzes the embryonic replacement of maternally contributed mRNA with new mRNA in single cells and shows dynamic spatio-temporal regulation of maternal mRNA decay and cell-type specific retention within the earliest specified cell types in zebrafish embryos.

Studying RNA decay remains a challenging task. Here, the authors present a technology that enables inducible rapid degradation of targeted mRNAs. Visualizing mRNA decay dynamics unveils insights into P-body function in RNA metabolism.

Here the authors uncovered CNOT3, a subunit of the CCR4-NOT complex, as an essential modulator of translation in leukemia. The work pointed to the potential of targeting the posttranscriptional circuitry via CNOT3 as a therapeutic vulnerability in acute myeloid leukemia.

Here, using mathematical modeling and an in vitro deadenylation system, the authors quantitatively demonstrate the effect of non-adenosines in the poly(A) tail and exemplify how tail sequence regulates mRNA stability.

Cryo-electron microscopy structures of intermediates formed during the degradation of the 30S ribosomal unit shed light on how the 3′ to 5′ exonuclease ribonuclease R controls the ribosomal degradation process.

The story of a paper that established the concept of codon optimality and its connection with translation efficiency and mRNA decay.

Predicting RNA degradation is a fundamental task in designing RNA-based therapeutic agents. Dual crowdsourcing efforts for dataset creation and machine learning were organized to learn biological rules and strategies for predicting RNA stability.

Olivia Rissland recounts the findings of a paper that was seminal to our understanding of mRNA decay.

Kate Meyer reminds us of a study of mRNA N⁶-methyladenosine that predated the epitranscriptomics era by decades.

Facultative heterochromatin occurs at regions that contain developmentally regulated genes. A study now reveals that the nutrient-sensitive TORC1 signalling pathway affects the RNA elimination machinery, thereby regulating the timely expression of meiotic genes embedded in facultative heterochromatic loci.