Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 4 Issue 5, May 2003

Death, symbolized by the autumn leaf, befalls tumor cells (star-shaped) that receive lytic granules (red in the original micrograph) from cytotoxic T lymphocytes. This month's Focus on Cell Death and Immunity comprises four reviews (starting on p. 399) and four more in Nature Reviews Immunology. All reviews and online features are available free to registered users through 1 July 2003. Original photo by Federico Gallo. Artwork by Lewis Long.

Volume 4 Issue 5

Subscribe

Editorial

Top of page ⤴

Round-up

Top of page ⤴

Review Article

Top of page ⤴

Commentary

  • Historical insight: Immunology's founding fathers argued fiercely about whether Metchnikoff's phagocytes or Ehrlich's antibodies were the most important mediators of immunity. Antibodies won out, but even after lymphocytes re-established cellular immunology, the humoralist-cellularist divide persisted.

    • Arthur M. Silverstein
    Commentary
Top of page ⤴

News & Views

  • Experiments based on the requirement for immunoglobulin gene transcription provide new insights into the elusive role played by AID in immunoglobulin class switching and hypermutation.

    • Sebastian D. Fugmann
    • David G. Schatz
    News & Views

  • Generation of B cell memory requires CD4+ T cell help and involves triggering of CD40 in target B cells. Several recent studies indicate that similar signals are involved in the generation of memory CD8+ T lymphocytes.

    • Corinne Tanchot
    • Benedita Rocha
    News & Views

  • Many infectious agents elicit a type I interferon response, but the molecular details that lead to IFN-α/β expression have remained obscure. New details are emerging about how specific TLRs signal IFN-α/β expression.

    • Gregory M. Barton
    • Ruslan Medzhitov
    News & Views
Top of page ⤴

Round-up

Top of page ⤴

Article

Top of page ⤴

Corrigendum

Top of page ⤴

Focus

  • This joint web focus with Nature Reviews Immunologyexamines recent inroads into how cell death pathways intersect with the immune system during both development and disease.

    Focus
Top of page ⤴

Search

Advanced search

Quick links