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Volume 9 Issue 5, May 2007

The kinetochore outer plate in PtK1 cells is a fibrous network (yellow) that forms multiple attachments to both the plus-end tips and the walls of spindle microtubules (red).

Volume 9 Issue 5

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Editorial

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News & Views

  • Tumorigenesis invariably requires multiple hits. New data shows that carcinogenesis originating from Ras mutations also requires increased Ras levels and a block of cellular senescence. Intriguingly, low non-transforming levels of Ras do not trigger senescence, suggesting that this programme is only activated in response to bona fide cancer threats.

    • Gerardo Ferbeyre
    News & Views

  • Generation of GTP-bound Ran on chromatin by its guanine nucleotide-exchange factor RCC1 provides a spatial signal that controls nuclear-envelope formation, nucleo-cytoplasmic transport and mitotic spindle assembly. A study now identifies an unusual post-translational modification, α-N-methylation of the amino-terminal tail of RCC1, which anchors the protein on chromosomes.

    • Paul R. Clarke
    News & Views

  • Voltage-dependent anion channels (VDACs) are thought to participate in mitochondrial-membrane permeabilization, an event that frequently delimits the frontier between cell life and death. Recent work casts doubts on their contribution to mitochondrial cell death.

    • Lorenzo Galluzzi
    • Guido Kroemer
    News & Views

  • p53 is usually referred to as a commonly altered tumour suppressor gene. A new study supports a decade of accumulating evidence that mutated p53 protein can gain new functions and also behave as an oncogene. This study specifically suggests that certain p53 mutants gain the ability to inhibit the MRN–ATM signalling pathway.

    • Michael B. Kastan
    • Elijahu Berkovich
    News & Views
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